Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Core Burdock Blend Ingredients & Drug Interactions

by Energetix

Core Burdock Blend label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Core Burdock Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Core Burdock Blend is a dietary supplement by Energetix with 6 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 2,182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm Bark Extract, Red Clover flower extract, Chinese Rhubarb Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Core Burdock Blend by Energetix

Ask about any prescription or over-the-counter medication and we check it for interactions with Core Burdock Blend by Energetix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Core Burdock Blend by Energetix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Botanical Extract Blend” is a proprietary blend — the label gives one combined amount (1.20 mL) without saying how much of each component you get.

Core Burdock Blend contains 6 active ingredients: burdock root extract, a botanical extract blend (whose components are listed separately), red clover flower extract, sheep sorrel aerial parts extract, white willow bark extract, slippery elm bark extract, and Chinese rhubarb root extract. It also contains water and ethyl alcohol as inactive ingredients.

Each ingredient is a plant-based extract chosen for traditional use in herbal blends, though the evidence supporting their effectiveness varies.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Menopausal symptoms — rated "Possibly Effective" (Rhubarb) (Natural Medicines).
  • On file: Pancreatitis — rated "Possibly Effective" (Rhubarb) (Natural Medicines).

The product facts show insufficient reliable evidence to rate burdock for acne, aging skin, breast cancer, common cold, or atopic dermatitis. Red clover is similarly rated insufficient for menopausal symptoms, osteoarthritis, osteoporosis, and hair loss.

Sorrel lacks established evidence for bronchitis, breast cancer, or sinus inflammation. Slippery elm's effectiveness for constipation, cough, inflammatory bowel disease, cancer, and diarrhea is rated insufficient.

Rhubarb is rated possibly effective only for menopausal symptoms and pancreatitis; its effectiveness for other uses listed (appendicitis, nasopharyngeal cancer, fatty liver disease, constipation) is insufficient. No ingredient in this blend has robust evidence we hold on file.

The evidence, ingredient by ingredient Burdock Red Clover Sorrel Slippery Elm Rhubarb

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Burdock is likely safe as a food and for short-term use in healthy adults, though human safety data are limited. It's generally well tolerated, but avoid it during pregnancy due to possible effects on the uterus, and avoid medicinal amounts while breastfeeding.

Rare serious allergic reactions including anaphylaxis have been reported, and a case of liver injury occurred (though other ingredients in that product may have been responsible). Red clover is generally well tolerated short-term but should be avoided during pregnancy because of its estrogen-like effects, and avoided while breastfeeding due to insufficient safety data.

Common side effects include muscle pain, nausea, and vaginal spotting. Sorrel is generally safe in food amounts but contains high oxalates; medicinal or concentrated doses carry risk of kidney damage and should be avoided during pregnancy and breastfeeding.

Slippery elm is generally well tolerated short-term but has limited safety data; avoid it during pregnancy and use with caution while breastfeeding. Rhubarb stalks are safe as food, but the root used as a laxative can cause cramping and isn't meant for long-term use.

Avoid medicinal rhubarb during pregnancy (may stimulate the uterus) and breastfeeding (laxative compounds may pass into milk). Chronic overuse of rhubarb can cause electrolyte loss, kidney damage, and dehydration.

Side effects, ingredient by ingredient Burdock Red Clover Sorrel Slippery Elm Rhubarb

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Burdock, Rhubarb, Red Clover, Sorrel, Slippery Elm.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; heart-rhythm medications.
  • For scale: 2,183 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Core Burdock Blend, check it against anticoagulant and antiplatelet drugs (moderate interaction with burdock, red clover, and sorrel). Red clover interacts moderately with estrogens, methotrexate, and tamoxifen.

Sorrel may affect fexofenadine (Allegra). Slippery elm may slow absorption of oral medications.

Rhubarb carries moderate interactions with diuretics, corticosteroids, warfarin, digoxin, stimulant laxatives, cyclosporine, and nephrotoxic and hepatotoxic drugs. Always run your exact medications through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This blend combines six plant extracts with a long history of traditional use but limited modern evidence of effectiveness. The main concern is interaction risk — especially with blood thinners, hormone therapy, and certain other medications — plus the cumulative effects of laxative ingredients if taken long-term or in high doses.

If you take any prescription medications, especially blood thinners, estrogen, methotrexate, heart medications, or diuretics, check with your pharmacist before starting. Pregnant or breastfeeding individuals should talk to their pharmacist or doctor before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Core Burdock Blend, straight from the product label.

Brand Energetix
Barcode (UPC) 364578010503
Net contents 2 Fluid Ounce(s); 59.1 mL
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 333027
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Core Burdock Blend by Energetix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.2 mL
Maximum serving Sizes:
1.2 mL
Servings per container
49
UPC/BARCODE
364578010503
IngredientAmount% DV
Burdock Root Extract0 NP--
Botanical Extract Blend1.2 mL--
Red Clover flower extract0 NP--
Sheep Sorrel aerial parts extract0 NP--
White Willow Bark Extract0 NP--
Slippery Elm Bark Extract0 NP--
Chinese Rhubarb Root Extract0 NP--

Other ingredients: Water, Purified, Ethyl Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

As a dietary supplement, take 30 to 40 drops orally (in water or juice, if desired) twice daily or as directed by a healthcare professional. Shake well before use.

Precautions

Do not use if neck wrap is broken or missing.

If pregnant or breast-feeding, ask a healthcare professional before use.

Keep out of reach of children.

Storage

Store at room temperature out of direct sunlight.

FDA Statement of Identity

Dietary Supplement

Formula

Spagyrically processed botanical

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Core Burdock Blend by Energetix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Core Burdock Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Core Burdock Blend by Energetix

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1.2 mL Dosage formLiquid Servings per container49 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Botanical Extract Blend

1.2 mL per serving

Other (inactive) ingredients: Water, Purified, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Core Burdock Blend by Energetix Drug Interactions

Want to check YOUR meds against Core Burdock Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,182Drugs
2,133 Moderate 49 Minor

Ingredients driving the most interactions

Slippery Elm Bark Extract 2,022
Red Clover flower extract 867
Chinese Rhubarb Root Extract 658
Sheep Sorrel aerial parts extract 169
Burdock Root Extract 122

Individual Drug Interactions

The ingredients in Core Burdock Blend interact with 2,182 drugs. Click any drug to see the details.

5 of the 6 ingredients in Core Burdock Blend interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm Bark Extract Red Clover flower extract Chinese Rhubarb Root Extract Sheep Sorrel aerial parts extract Burdock Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Core Burdock Blend with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Slippery Elm Bark Extract1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm Bark Extract full monograph & interactions

Red Clover flower extract9 drug types · 867 drugs

Estrogens

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Red clover contains phytoestrogens which might have estrogenic activity in some people. Theoretically, red clover might compete for estrogen receptors and interfere with estrogen-containing drug therapy.

Likelihood Probable Evidence D
Methotrexate (Trexall, Others)

Theoretically, red clover might increase the risk of methotrexate toxicity.
In a case report, a 52-year-old female receiving weekly methotrexate injections for psoriasis developed symptoms of methotrexate toxicity, including severe vomiting and epigastric pain, after three days of taking red clover 430 mg daily. Toxicity resolved after red clover was discontinued. However, no liver function tests or methotrexate levels were reported.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the phytoestrogens in red clover might interfere with tamoxifen.
In vitro and animal research suggests that genistein, a constituent of red clover, might antagonize the antitumor effects of tamoxifen. However, there is some evidence from an animal study that red clover does not reduce the efficacy of tamoxifen. Until more is known, tell patients taking tamoxifen to avoid red clover.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
In vitro research suggests that genistein in red clover has antiplatelet effects, and historically, red clover was thought to have anticoagulant effects due to its coumarin content. However, some experts state that this is unlikely as most natural coumarins have not been shown to have anticoagulant effects, and their content in red clover is low. Additionally, some clinical research in postmenopausal patients found no effect on coagulation or prothrombin time with the use of red clover flowering tops 378 mg daily for 12 months or red clover isoflavone (Rimostil) 50 mg daily for 2 years.

Likelihood Unlikely Evidence B
Caffeine

Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Red clover contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. However, this effect does not seem to occur with the lower amounts of genistein found in red clover. A clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
In vitro evidence shows that red clover inhibits CYP1A2. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that red clover weakly inhibits CYP2C19. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
In vitro evidence suggests that red clover might inhibit CYP2C9. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of tolbutamide, a CYP2C9 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
In vitro evidence shows that red clover might inhibit CYP3A4 isoenzymes. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of alprazolam, a CYP3A4 probe substrate.

Likelihood Unlikely Evidence B
Red Clover flower extract full monograph & interactions

Chinese Rhubarb Root Extract8 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
Chinese Rhubarb Root Extract full monograph & interactions

Sheep Sorrel aerial parts extract3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Sheep Sorrel aerial parts extract full monograph & interactions

Burdock Root Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Burdock Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Core Burdock Blend, from the product label.

Energetix

See all Energetix products
Name
Energetix Corp.
City
Dahlonega
State
GA
ZipCode
30533
Phone Number
800.990.7085
Web Address
www.energetix.com
Pharmacist Counseling Corner

Core Burdock Blend by Energetix: Common Questions

Does Core Burdock Blend by Energetix interact with any medications?
Yes. Based on its ingredients, Core Burdock Blend has a known interaction with 2,182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Core Burdock Blend contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No — avoid medicinal amounts during pregnancy. Burdock may affect the uterus, red clover has estrogen-like effects, and rhubarb may stimulate the uterus and bowels. The safety data don't support its use in pregnancy. Talk with your doctor or pharmacist about what's safe for you.
Can I take this while breastfeeding?
Not without checking with your pharmacist or doctor first. Burdock, red clover, and slippery elm all have insufficient safety data for breastfeeding. Rhubarb's laxative compounds may pass into breast milk. There isn't enough information to know either way, so get personalized advice before using it.
Does this actually work for what it's supposed to treat?
The evidence isn't established in our data. All six active ingredients are rated insufficient for their traditional uses — meaning we don't hold reliable evidence that they work for the conditions this blend might target. It's used because of long historical use, not modern clinical proof.
What's in this that makes it work?
The blend contains burdock root, red clover, sorrel, white willow bark, slippery elm, and rhubarb root — all chosen for traditional herbal use. However, each ingredient has insufficient evidence to rate how well it actually works, so we can't point to a specific active component we know is effective.
Are there fillers or other stuff I should know about?
The product contains water and ethyl alcohol as inactive ingredients beyond the six plant extracts. Those are excipients (meaning they help deliver the active ingredients), not added fillers in the sense of inert padding.
What side effects might I get?
The most common are gastrointestinal — rhubarb can cause cramps, diarrhea, nausea, and vomiting, especially with overuse. Burdock and red clover are generally well tolerated, but rare serious allergic reactions are possible. Red clover may cause muscle pain, nausea, and vaginal spotting. Sorrel exposure can trigger allergy symptoms in sensitive people. Slippery elm and sorrel can cause contact dermatitis.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Core Burdock Blend label
Go deeper

The Full Monographs Behind Core Burdock Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Red Clover

Interacts with 867 drugs

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot flashes. The evidence is mixed and genera...

Read the full Red Clover monograph → Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph →
Sources

Sources & How We Checked

Core Burdock Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 66 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Burdock 11 references
  1. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  2. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
  3. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
  4. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
  5. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
  6. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
  7. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
  8. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
  9. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
  10. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
  11. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

See these in context on the Burdock monograph →

Red Clover 24 references
  1. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
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Sorrel 8 references
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See these in context on the Sorrel monograph →

Slippery Elm 3 references
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Rhubarb 20 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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