Interactions on record — worth a quick check against your medications. Based on 4 of 7 ingredients. Check your meds →
Dietary supplement

Smrutihills Ingredients & Drug Interactions

by Herbal Hills

Smrutihills label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Smrutihills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Smrutihills is a dietary supplement by Herbal Hills with 7 active ingredients. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, adhd symptoms.Based on those ingredients, 1,494 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vacha, Brahmi, Guduchi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Smrutihills by Herbal Hills

Ask about any prescription or over-the-counter medication and we check it for interactions with Smrutihills by Herbal Hills — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Smrutihills by Herbal Hills

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Proprietary Herbal Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Smrutihills contains 7 ingredients total. The active herbs are Brahmi (also called Bacopa, traditionally used for memory and cognition), Mandukparnee (Gotu Kola, used for circulation and wound healing), Guduchi (Tinospora cordifolia, used for immunity and blood sugar), Vacha (Calamus, used in traditional practice for digestion and nervous system support), Jyotishmati, and Shankhapushpi.

The blend is processed in Siddha Ghruta, a traditional herbal preparation method. The capsules also contain inactive ingredients: gelatin, glycerin, sorbitol, methylparaben, propyl paraben, and titanium dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports maintenance of mental function.
  • We looked for evidence on: Memory, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Generalized anxiety disorder (GAD), age-related cognitive decline, mental clarity.
  • The closest evidence on file: Gotu Kola is rated "Possibly Ineffective" for Cognitive function (Natural Medicines).
  • Also on file: Gotu Kola is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Attention deficit-hyperactivity disorder (ADHD).
  • Also on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

The evidence for most of Smrutihills' intended uses is not established in the data we hold. Brahmi has insufficient reliable evidence for Alzheimer disease, sexual dysfunction, ADHD, back pain, cognitive function, and cognitive impairment.

Mandukparnee shows possibly effective evidence for venous insufficiency and burns, but possibly ineffective for cognitive function; evidence is insufficient for Alzheimer disease and generalized anxiety. Guduchi is possibly effective for diabetes, but evidence is insufficient for hay fever, asthma, athletic performance, cancer, and hepatitis.

We have no effectiveness data on file for Vacha, Jyotishmati, or Shankhapushpi. If you're considering this product for a specific health goal, talk with your doctor or pharmacist about whether the evidence supports its use.

The evidence, ingredient by ingredient Bacopa Gotu Kola Tinospora Cordifolia Calamus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Brahmi and Mandukparnee are generally well tolerated in short-term studies, but long-term safety data are limited. Guduchi and Vacha carry more serious concerns.

Guduchi has rare reports of liver injury — in one case series, 49 patients developed hepatitis or acute liver failure after taking Tinospora cordifolia for 42–90 days, with 2 requiring liver transplants and 4 deaths. Vacha is considered unsafe for use because some forms contain beta-asarone, a compound the FDA banned from food due to cancer risk, and it may cause nausea, vomiting, intestinal paralysis, and tachycardia.

Common side effects from Brahmi include abdominal cramps, diarrhea, dry mouth, headache, and nausea (reported in 12–30% of users); it may also cause drowsiness, insomnia, or vivid dreams. Mandukparnee may cause gastric irritation and nausea orally, and allergic contact dermatitis if applied to skin.

Guduchi commonly causes headache and nasal pain. During pregnancy, Brahmi and Guduchi have insufficient safety data and are best avoided; Mandukparnee is possibly safe in pregnancy but lacks solid evidence; Vacha is considered likely unsafe.

During breastfeeding, all ingredients lack sufficient safety data — Brahmi, Guduchi, and Vacha are best avoided, and Mandukparnee's safety is unknown.

Side effects, ingredient by ingredient Bacopa Gotu Kola Tinospora Cordifolia Calamus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Gotu Kola, Bacopa, Calamus, Tinospora Cordifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,495 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Smrutihills, double-check these medication types with your doctor or pharmacist: drugs metabolized by liver enzymes CYP1A2, CYP2C19, CYP2C9, and CYP3A4 (a very large group including many heart, cholesterol, cancer, and psychiatric drugs); blood pressure medications (Vacha may lower blood pressure); CNS depressants like sedatives, sleeping pills, and alcohol (Mandukparnee and Vacha may increase drowsiness); anticholinergic drugs and cholinergic drugs (Brahmi and Vacha may interfere); cevimeline (a case report of serious effects with Brahmi); thyroid hormone (Minor concern with Brahmi); MAOIs or older antidepressants (Vacha may potentiate effects); immunosuppressant drugs (Guduchi may reduce their effectiveness); diabetes medications (Guduchi may increase low blood sugar risk); and H2-blockers for acid reflux (Vacha may reduce their effectiveness). If you take any of these, confirm with your pharmacist or doctor before starting this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Smrutihills contains a mix of traditional Ayurvedic herbs with limited evidence for most conditions it may be marketed for. The biggest concern is its interaction potential with many common medications — especially drugs metabolized by liver enzymes — and the serious safety signals around Vacha (cancer risk) and Guduchi (rare liver injury reports).

If you take any prescription or over-the-counter medication, or have liver disease or any chronic condition, check your exact medications on this page's interaction tool and discuss this product with your own doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Smrutihills, straight from the product label.

Brand Herbal Hills
Barcode (UPC) 8906068413900
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 75317
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Smrutihills by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Sofgel Capsule(s)
Maximum serving Sizes:
2 Sofgel Capsule(s)
Servings per container
60
UPC/BARCODE
8906068413900
IngredientAmount% DV
Proprietary Herbal Blend1000 mg--
processed in Siddha Ghruta0 NP--
Brahmi0 NP--
Mandukparnee0 NP--
Guduchi0 NP--
Vacha0 NP--
Jyotishmati0 NP--
Shankhapushpi0 NP--

Other ingredients: Gelatin, Glycerin, Sorbitol, Methylparaben, Propyl Paraben, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

General Statements

Suggested Use: ~ Supports maintenance of mental function

Mfg. Lic. No. : MB/AYU/001-A/11

(An ISO 22000:2005 Certified Company)

Back to nature

Memory support Support focus

~ Pure ~ Natural ~ Effective

Colour Name: Brilliant Blue.

Seals/Symbols

JAS-ANZ ICS ISO 22000:2005 Reg. No.: RH91/7301

GMP Good Manufacturing Practice

Halal India www.halalindia.com

Formula

Halal India www.halalindia.com

Formulation with unrevealed secrets of medicated Siddha Ghruta (Clarified butter)

Caution: Contains lactose and milk proteins.

Storage

Store in a cool dry place away from direct sunlight.

Precautions

Keep out of reach of children.

Do not use if inner seal is broken or missing.

Caution: Contains lactose and milk proteins.

Pregnant or lactating women are advised to consume herbal products under the advice of the healthcare practitioner.

Suggested/Recommended/Usage/Directions

Direction For Use: As a dietary supplement take 2 soft gel capsules daily in the morning. It should ideally be taken on empty stomach before meals. For better results take with warm water or milk.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Smrutihills by Herbal Hills label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Smrutihills label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Smrutihills by Herbal Hills

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Sofgel Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Herbal Blend

1000 mg per serving

Processed in Siddha Ghruta

0 NP per serving Form: Clarified Butter

Other (inactive) ingredients: Gelatin, Glycerin, Sorbitol, Methylparaben, Propyl Paraben, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Smrutihills by Herbal Hills Drug Interactions

Want to check YOUR meds against Smrutihills?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,494Drugs
1,463 Moderate 31 Minor

Ingredients driving the most interactions

Vacha 1,117
Brahmi 930
Guduchi 612
Mandukparnee 579

Individual Drug Interactions

The ingredients in Smrutihills interact with 1,494 drugs. Click any drug to see the details.

4 of the 7 ingredients in Smrutihills interact with drugs. Each result below shows which ingredient is responsible. Vacha Brahmi Guduchi Mandukparnee

Each ingredient & the kinds of drugs it affects

For each ingredient in Smrutihills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vacha10 drug types · 1,117 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and calamus might decrease the effectiveness of the anticholinergic drug.
In vitro evidence shows that calamus can inhibit acetylcholinesterase (AChE).

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking calamus with other antihypertensive medications might increase the risk of hypotension.
Animal research shows that calamus decreases the rate and strength of the heartbeat, which might lower blood pressure. use with caution.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and calamus might have an additive effect and increase the risk of cholinergic effects.
In vitro evidence shows that calamus can inhibit acetylcholinesterase (AChE).

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.
Animal research shows that calamus is a CNS depressant and increases gamma-aminobutyric acid levels.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effects.
In vitro research shows that calamus extract inhibits CYP2D6 enzyme.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.
In vitro research shows that calamus extract inhibits CYP3A4 enzyme.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, calamus might potentiate the effects and adverse effects of MAOIs.
Some reports suggest that calamus increases the effects of MAOIs.

Likelihood Possible Evidence D
Antacids

Theoretically, taking calamus might reduce the effectiveness of antacids.
Some research suggests that calamus lowers gastric pH.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, taking calamus might reduce the effectiveness of H2-blockers.
Some research suggests that calamus lowers gastric pH.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, taking calamus might reduce the effectiveness of PPIs.
Some research suggests that calamus lowers gastric pH.

Likelihood Possible Evidence D
Vacha full monograph & interactions

Brahmi8 drug types · 930 drugs

Anticholinergic Drugs

Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.

Likelihood Possible Evidence D
Cevimeline (Evoxac)

Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.

Likelihood Possible Evidence D
Brahmi full monograph & interactions

Guduchi6 drug types · 612 drugs

Antidiabetes Drugs

Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research in adults with type 2 diabetes shows that Tinospora cordifolia can reduce fasting blood glucose and glycated hemoglobin. Additionally, animal research shows that Tinospora cordifolia has hypoglycemic effects.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
In vitro and animal research shows that Tinospora cordifolia has immunostimulant effects.

Likelihood Possible Evidence D
Guduchi full monograph & interactions

Mandukparnee2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Mandukparnee full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Smrutihills, from the product label.

Herbal Hills

See all Herbal Hills products
Name
Isha Agro Developers Pvt. Ltd.
Street Address
Plot #33, Govt. Indl. Est., Charkop, Kandivali (W)
City
Mumbai-67
Pharmacist Counseling Corner

Smrutihills by Herbal Hills: Common Questions

Does Smrutihills by Herbal Hills interact with any medications?
Yes. Based on its ingredients, Smrutihills has a known interaction with 1,494 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Smrutihills contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Brahmi safe to take during pregnancy?
No. Brahmi (Bacopa) does not have enough safety data in pregnancy, and the guidance is to avoid it. Talk with your doctor or pharmacist for personalized advice if you're pregnant or planning to be.
Can I take Smrutihills if I'm breastfeeding?
The ingredients in Smrutihills lack sufficient safety data during breastfeeding. Brahmi, Guduchi, and Vacha are best avoided while nursing. Mandukparnee's safety is unknown. Discuss with your doctor or pharmacist before use.
What are the most common side effects of Brahmi?
Brahmi most commonly causes abdominal cramps, diarrhea, dry mouth, headache, and nausea. It may also cause drowsiness, insomnia, or vivid dreams in some people. These side effects occurred in 12–30% of people in trials.
Does Smrutihills work for memory and ADHD?
The evidence for Brahmi in Alzheimer disease, ADHD, and cognitive function is insufficient — we don't have solid data that it works for these uses. The same is true for most of the other ingredients' intended uses in this product.
Why is there a warning about Vacha in Smrutihills?
Vacha (Calamus) is considered unsafe because some forms contain beta-asarone, a compound the FDA banned from food due to cancer risk. It may also cause nausea, vomiting, intestinal paralysis, and dangerous heart rate changes. The safety of Vacha in this product depends on which part of the plant is used and how it's processed.
Are there any serious safety concerns with the other ingredients?
Yes. Guduchi (Tinospora cordifolia) has rare but serious reports of liver injury; in one case series, 49 patients developed hepatitis or acute liver failure after 42–90 days of use, with 2 requiring liver transplants and 4 deaths. Mandukparnee and Brahmi are generally well tolerated short-term, but long-term safety data are limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Smrutihills label
Go deeper

The Full Monographs Behind Smrutihills’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacopa

Interacts with 930 drugs

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...

Read the full Bacopa monograph → Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph → Herb & supplement monograph

Tinospora Cordifolia

Interacts with 612 drugs

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies s...

Read the full Tinospora Cordifolia monograph → Herb & supplement monograph

Calamus

Interacts with 1,117 drugs

Calamus is a swamp plant with a long history in Ayurvedic and traditional Chinese medicine, mostly for digestive and nervous-system complaints. However, it contains beta-asarone, a compound...

Read the full Calamus monograph →
Sources

Sources & How We Checked

Smrutihills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 59 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacopa 12 references
  1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
  2. Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
  3. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
  4. Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
  5. Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
  6. Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
  7. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
  8. Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
  9. Prabhakar S, Vishnu VY, Modi M, et al. Efficacy of Bacopa monnieri (Brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study. Ann Indian Acad Neurol 2020;23(6):767-73. PubMed
  10. Acquarulo B, Tandon P, Macica CM. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. J Med Case Rep 2022;16(1):253. PubMed
  11. Keegan AP, Stough C, Paris D, et al. Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderl
  12. Yaworski AM, Blyumin M, Chang T, Mammen AL, Greene M. Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa. Muscle Nerve 2023;67(2):E1-E3.

See these in context on the Bacopa monograph →

Gotu Kola 18 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
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See these in context on the Gotu Kola monograph →

Tinospora Cordifolia 16 references
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  2. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
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  12. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
  13. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
  14. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
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  16. May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.

See these in context on the Tinospora Cordifolia monograph →

Calamus 13 references
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  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
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  4. Shoba, F. G. and Thomas, M. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol 2001;76(1):73-76. PubMed
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  7. Panchal, G. M., Venkatakrishna-Bhatt, H., Doctor, R. B., and Vajpayee, S. Pharmacology of Acorus calamus L. Indian J Exp.Biol 1989;27(6):561-567.
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  9. Pandit S, Mukherjee PK, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of a-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 2011;82(3):369-74.
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  12. Federal Register. Volume 33, Page 6967. U.S. Government Publishing Office. http://api.fdsys.gov/link?collection=fr&volume=33&page=6967. Accessed May 23, 2018.
  13. Electronic Code of Federal Regulations. Title 21. Part 189 - Substances Prohibited From Use in Human Food. Available at: https://www.ecfr.gov/cgi-bin/text-idx?SID=259fa8a1284cad42676075c8425c7333&mc=true&node=pt21.3.189&rgn=div5.

See these in context on the Calamus monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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