SuperHD Razor Ingredients & Drug Interactions
by Cellucor
What is this page for?
First and foremost: checking SuperHD Razor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
SuperHD Razor is a dietary supplement by Cellucor with 5 active ingredients. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 1,035 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioperine Black Pepper (Piper nigrum) fruit extract, Synetrim CQ (Cissus quadrangularis) stem and leaf extract, Carnitine Tartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against SuperHD Razor by Cellucor
Ask about any prescription or over-the-counter medication and we check it for interactions with SuperHD Razor by Cellucor — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of SuperHD Razor by Cellucor
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
SuperHD Razor contains five active ingredients. Thiamine is a B vitamin that supports energy and nerve function.
Black pepper fruit extract (Bioperine) is included as a bioavailability enhancer — it may help your body absorb other compounds. Carnitine tartrate supports cellular energy production.
Cissus quadrangularis stem and leaf extract (Synetrim CQ) is a plant compound, and Tonalin CLA is a conjugated linoleic acid. The capsule is made from gelatin, glycerin, beeswax, and other inactive ingredients like silicon dioxide and colorants.
Does it work?
Not established
Thiamine is effective for treating thiamine deficiency and Wernicke-Korsakoff syndrome, a serious neurological condition. It's possibly effective for period pain (dysmenorrhea).
We don't have established effectiveness ratings in our data for black pepper, carnitine tartrate, or Cissus quadrangularis as ingredients in this product formulation. Carnitine tartrate alone is possibly effective for heart failure and high cholesterol, and Cissus quadrangularis is possibly effective for obesity, but evidence for the other uses listed is insufficient.
The evidence for this particular supplement's overall purpose isn't established in the data we hold.
How safe is it?
Well-documented data
Thiamine is generally very safe by mouth in normal amounts; rare allergic reactions like dermatitis have been reported. Black pepper in food amounts is well tolerated, though concentrated supplements should be used cautiously — burning aftertaste, indigestion, and rarely allergic reactions are possible.
Carnitine tartrate is generally well tolerated at typical doses but can cause stomach upset, nausea, diarrhea, and a fish-like body odor at higher doses. Cissus quadrangularis is well tolerated in short-term use, though long-term safety isn't well studied; headache and insomnia have been reported, but at rates similar to placebo.
Safety data for Tonalin CLA isn't on file. Thiamine is likely safe in pregnancy and lactation when used at recommended supplement amounts under your provider's guidance.
For the other ingredients, pregnancy and breastfeeding safety data is either not available or advises against use — talk with your doctor or pharmacist before taking this product if you're pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking SuperHD Razor, double-check if you're on any heart medications (especially propranolol), blood thinners (warfarin or acenocoumarol), diabetes medications, seizure drugs (like phenytoin), HIV antivirals (like nevirapine), tuberculosis drugs (like rifampin), asthma medications (like theophylline), cholesterol drugs (like atorvastatin), thyroid hormone replacement, or immunosuppressants (like cyclosporine). Black pepper can increase blood levels of these drugs; carnitine may amplify blood thinners or reduce thyroid drug effectiveness; and Cissus quadrangularis may lower blood sugar further.
The medication checker on this page can tell you whether your specific drugs interact.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
SuperHD Razor may be worth considering if you're not on medications that interact with its ingredients — thiamine, black pepper, carnitine, and Cissus quadrangularis all have documented interactions with common drugs. If you take heart medications, blood thinners, diabetes drugs, seizure medications, thyroid hormone, or tuberculosis or HIV antivirals, check your exact medications with the tool on this page first.
Anyone pregnant or breastfeeding should talk with their pharmacist or doctor before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about SuperHD Razor, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for SuperHD Razor by Cellucor, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Calories from Fat | 10 Calorie(s) | -- |
| Total Fat | 1 Gram(s) | 2% |
| Thiamine | 1 mg | 67% |
| Bioperine Black Pepper (Piper nigrum) fruit extract | 0 NP | -- |
| Carnitine Tartrate | 0 NP | -- |
| SuperHD Razor Blend | 1.6145 Gram(s) | -- |
| Tonalin CLA | 0 NP | -- |
| Synetrim CQ (Cissus quadrangularis) stem and leaf extract | 0 NP | -- |
Other ingredients: Gelatin, Glycerin, Water, Beeswax, Sunflower Lecithin, Silicon Dioxide, Titanium Dioxide, Sorbitol, FD&C Yellow #5, FD&C Blue #1
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Take one serving (2 softgels) twice daily before meals. Do not take two servings (4 softgels) at once, but consume prior to two different meals throughout day. For best results, use for 12 consecutive weeks. Use only as directed.
Precautions
Use only as directed. Warning: This product is only intended to be consumed by healthy adults, 18 years of age or older.
Do not use this product if you are pregnant or nursing. Before using this product, consult with a licensed, qualified, health care professional, including but not limited to, if you are taking any prescription drug or over-the-counter medication, or have any existing medical condition.
Immediately discontinue use and contact a medical doctor if you experience any adverse reaction to this product. Discontinue use 2 weeks prior to surgery. Do not use if safety seal is broken or missing.
Keep out of reach of children.
Storage
Store in a cool dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Weight loss formulation Maintain lean muscle and reduce body fat
4 week supply
Made in the U.S.A. using U.S. and imported ingredients and components.
Ignite your goals Extinguish your doubts 104291
You're ready to transform and take your physique to the next level. You need a complete program that takes into account all the variables of burning fat and maintaining lean muscle to accelerate your results. Through years of research and innovation. We've taken our best-selling weight loss product and engineered a system to bring your body into high-definition!
This stimulant free formulation can help promote weight loss by decreasing the number and size of fat cells, decreasing the activity of lipoprotein lipase (LPL) enzymes which help store fats and increasing the rate at which your fat cells disintegrate.
This formulation utilizes natural botanical ingredients that promote the excretion of that excess water, getting you one step closed to that highly-defined and toned physique.
Formula
With clinically studied Tonalin CLA and Synetrim CQ
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Tonalin For reducing body fat Tonalin CLA is an exclusively licensed product of BASF Personal Care and Nutrition GmbH.
Synetrim CQ is a trademark of Icon Group, LLC and is protected under U.S. Patent 7,175,859.
BioPerine is a registered trademark of Sabinsa Corportation.
Cellucor, SuperHD Razor, SuperHD Fire and SuperHD Water are trademarks of and distributed by: Nutrabolt
SuperHD Fire SuperHD Fire is a two-stage daily weight loss formula targeting fat loss, sustained energy, optimized performance and well-being. This potent thermogenic has been designed with the patented, clinically studies on DygloFit have demonstrated that participants who consumed DygloFit for 8 weeks saw reductions in weight, waist size, hip size and body fat percentage. SuperHR Fire is available in both stimulant and stimulant free options to best fit your personalized needs. SuperHR Razor SuperHR Razor was designed with the clinically researched and tested ingredients Tonalin CLA & Synetrim CQ.
Enhance your results by pairing with a thermogenic like SuperHD Fire. SuperHD Water SuperHD Water has been formulated to help you achieve your leanest physique by assisting your body's ability to reduce the temporary accumulation of excess water, which can be caused by stress, physical activity and sodium intake.
Synetrim CQ Multi-patented and clinically tested Synetrim CQ is derived from the botanical Cissus quadrangularis and is the only Cissus quadrangularis extract patented for weight loss. Synetrim CQ can help promote weight loss. Reduce body size, and reduce caloric intake by blocking enzymes that digest carbohydrates and dietary fats. Tonalin CLA Tonalin is the most clinically researched CLA ingredient. Conjugated Linoleic Acid (CLA) is a fatty acid sustainably sourced from natural safflower oil, which is known to improve overall body composition. Tonalin CLA can help achiece body fat reduction and maintain lean muscle development. CLA works in the body in four different ways. CLA decreases the number and size of fat cells, thus lowering body fat mass; decreases the activity of lipoprotein lipase (LPL) enzymes which help to store triglycerides (fats) in fat cells; increases the rate at which fat cells disintegrate; and increases activity of the enzyme carnitine palmitoyltransferase (CPT) so fat is burned up fasted.
General
104595
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
SuperHD Razor by Cellucor label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in SuperHD Razor by Cellucor
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container56 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Thiamine
Interacts with3 drugs
Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...
Thiamine monograph & interactionsSuperHD Razor Blend
Other (inactive) ingredients: Gelatin, Glycerin, Water, Beeswax, Sunflower Lecithin, Silicon Dioxide, Titanium Dioxide, Sorbitol, FD&C Yellow #5, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.
SuperHD Razor by Cellucor Drug Interactions
HelloPharmacist Interaction Report
SuperHD Razor by Cellucor contains several ingredients with documented medication interactions.
The most serious is black pepper, which has Moderate interactions with eight medication types: it can increase blood levels of heart drugs like propranolol, HIV antivirals like nevirapine, tuberculosis medications like rifampin, seizure drugs like phenytoin, immunosuppressants like cyclosporine, sedatives like pentobarbital, cholesterol drugs like atorvastatin, and asthma medications like theophylline.
Read the full breakdown — every affected drug type, severity by severity
Carnitine tartrate carries Moderate interactions with blood thinners (anticoagulants) — both warfarin and acenocoumarol — which may increase their anticoagulant effects and raise bleeding risk. It also theoretically reduces the effectiveness of thyroid hormone replacement.
Cissus quadrangularis has a Moderate interaction with diabetes medications (antidiabetes drugs), raising the risk of low blood sugar (hypoglycemia). Thiamine has one Minor interaction with trimethoprim, an antibiotic that may increase thiamine blood levels.
We could not check Tonalin CLA — we hold no interaction data for it. Altogether, these interactions span 1,021 individual medications.
Before starting SuperHD Razor, run your exact medications through the checker on this page to see whether any conflict with this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against SuperHD Razor?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in SuperHD Razor interact with 1,035 drugs. Click any drug to see the details.
4 of the 5 ingredients in SuperHD Razor interact with drugs. Each result below shows which ingredient is responsible. Bioperine Black Pepper (Piper nigrum) fruit extract Synetrim CQ (Cissus quadrangularis) stem and leaf extract Carnitine Tartrate Thiamine
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of P-glycoprotein substrates.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with SuperHD Razor — through 2 ingredients. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acarbose interactionSynetrim Cq (cissus Quadrangularis) Stem And Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Synetrim Cq (cissus Quadrangularis) Stem And Leaf Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with SuperHD Razor — through 2 ingredients. Tap an ingredient for the detail:
Carnitine TartrateAcenocoumarol (sintrom) Moderate
Interaction Summary
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
Read the full Carnitine Tartrate + Acenocoumarol interactionBioperine Black Pepper (piper Nigrum) Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with SuperHD Razor — through 1 ingredient. Tap an ingredient for the detail:
Bioperine Black Pepper (piper Nigrum) Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine Black Pepper (piper Nigrum) Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in SuperHD Razor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bioperine Black Pepper (Piper nigrum) fruit extract
Anticoagulant/Antiplatelet Drugs
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.
Antidiabetes Drugs
Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Atorvastatin (Lipitor)
Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.
Cyclosporine (Neoral, Sandimmune)
Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.
Lithium
Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.
Nevirapine (Viramune)
Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.
P-Glycoprotein Substrates
Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.
Pentobarbital (Nembutal)
Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.
Phenytoin (Dilantin)
Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.
Propranolol (Inderal)
Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.
Rifampin (Rifadin)
Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.
Theophylline
Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.
Amoxicillin (Amoxil, Trimox)
Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.
Carbamazepine (Tegretol)
Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.
Synetrim CQ (Cissus quadrangularis) stem and leaf extract
Antidiabetes Drugs
Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.
Carnitine Tartrate
Acenocoumarol (Sintrom)
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.
Thyroid Hormone
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.
Warfarin (Coumadin)
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.
Thiamine
Trimethoprim (Proloprim)
Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.
Brand information
Manufacturer and brand details for SuperHD Razor, from the product label.
Cellucor
See all Cellucor products- Name
- Nutrabolt
- Street Address
- 3891 S. Traditions Dr.
- City
- Bryan
- State
- TX
- ZipCode
- 77807
- Phone Number
- 1.866.927.9686
- Web Address
- www.cellucor.com
SuperHD Razor by Cellucor: Common Questions
Does SuperHD Razor by Cellucor interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is thiamine in this product for?
Does SuperHD Razor contain any fillers?
Can I take SuperHD Razor if I'm pregnant?
What's black pepper extract doing in a weight-loss supplement?
Does this product work for weight loss or body composition?
What's the fish-like smell I might get from this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if SuperHD Razor is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind SuperHD Razor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Thiamine
Interacts with 3 drugsThiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...
Read the full Thiamine monograph → Herb & supplement monographBlack Pepper
Interacts with 1,019 drugsBlack pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...
Read the full Black Pepper monograph → Herb & supplement monographL-carnitine
Interacts with 19 drugsL-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...
Read the full L-carnitine monograph → Herb & supplement monographCissus Quadrangularis
Interacts with 86 drugsCissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...
Read the full Cissus Quadrangularis monograph →Sources & How We Checked
SuperHD Razor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 82 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Thiamine 7 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
- Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
- Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
- Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.
Black Pepper 29 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
- Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
- Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
- Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
- Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
- Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
- Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term en
- Myers, B. M., Smith, J. L., and Graham, D. Y. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82(3):211-214.
- Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. PubMed
- Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532.
- Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. PubMed
- Usia, T., Iwata, H., Hiratsuka, A., Watabe, T., Kadota, S., and Tezuka, Y. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine. 2006;13(1-2):67-73. PubMed
- Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487.
- Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. PubMed
- Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. PubMed
- Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281.
- Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289. PubMed
- Sharma, P., Varma, M. V., Chawla, H. P., and Panchagnula, R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 2005;60(11-12):874-883. PubMed
- Aher, S., Biradar, S., Gopu, C. L., and Paradkar, A. Novel pepper extract for enhanced P-glycoprotein inhibition. J Pharm.Pharmacol. 2009;61(9):1179-1186. PubMed
- Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc.Physicians India 1985;33(3):223-224.
- Marotta, R. B. and Floch, M. H. Diet and nutrition in ulcer disease. Med Clin North Am 1991;75(4):967-979. PubMed
- Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
- Gimenez L, Zacharisen M. Severe pepper allergy in a young child. WMJ. 2011 Jun;110(3):138-9.
- Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z. Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment. Life Sci. 2019;218:314-323. PubMed
- Thomas AB, Choudhary DC, Raje A, Nagrik SS. Pharmacokinetics and pharmacodynamic herb-drug interaction of piperine with atorvastatin in rats. J Chromatogr Sci 2021;59(4):371-80. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Lin F, Hu Y, Zhang Y, Zhao L, Zhong D, Liu J. Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling. Int J Mol Sci 2024;25(20):10955. PubMed
L-carnitine 41 references
- Ellaway CM, Williams K, Leonard H, et al. Rett syndrome: randomized controlled trial of L-carnitine. J Child Neurol 1999;14:162-7. PubMed
- Anon. Carnitor (levocarnitine) package insert. Sigma-Tau Pharmaceuticals Inc, Gaithersburg, MD. December 1999.
- Cherchi A, Lai C, Angelino F, et al. Effects of L-carnitine on exercise tolerance in chronic stable angina: a multicenter, double-blind, randomized, placebo-controlled, crossover study. Int J Clin Pharmacol Ther Toxicol 1985;23:569-72.
- Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology 1997;35:16-23. PubMed
- Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
- Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
- Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
- Evans AM, Fornasini G. Pharmacokinetics of L-carnitine. Clin Pharmacokinet 2003;42:941-67. PubMed
- 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
- Ciacci C, Peluso G, Iannoni E, et al. L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study. Dig Liver Dis 2007;39:922-8. PubMed
- Cruciani RA, Dvorkin E, Homel P, et al. Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study. J Pain Symptom Manage 2006;32:551-9. PubMed
- Lebrun C, Alchaar H, Candito M, et al. Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. Mult Scler 2006;12:321-4. PubMed
- Malaguarnera M, Cammalleri L, Gargante MP, et al. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr 2007;86:1738-44. PubMed
- Mantovani G, Maccio A, Madeddu C, et al. Randomized phase III clinical trial of five different arms of treatment in 322 patients with cancer cachexia. Oncologist 2010;15:200-11.
- Angelova-Fischer I, Rippke F, Fischer TW, Neufang G, Zillikens D. A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne. J Eur Acad Dermatol Venereol. 2013 Jul PubMed
- Hatamkhani S, Khalili H, Karimzadeh I, Dashti-Khavidaki S, Abdollahi A, Jafari S. Carnitine for prevention of antituberculosis drug-induced hepatotoxicity: a randomized, clinical trial. J Gastroenterol. Hepatol. 2014 May;29(5):997-1004. PubMed
- Boehm G, Stahl B. Oligosaccharides from milk. J Nutr 2007;137(3 Suppl 2):847S-849S.
- Van Oudheusden, L. J. and Scholte, H. R. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot.Essent.Fatty Acids 2002;67(1):33-38. PubMed
- Derosa, G., Cicero, A. F., Gaddi, A., Mugellini, A., Ciccarelli, L., and Fogari, R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther 2003;25(5):1429-1439. PubMed
- Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. J Dermatol.Sci 2007;48(2):141-144. PubMed
- Kumar, A., Singh, R. B., Saxena, M., Niaz, M. A., Josh, S. R., Chattopadhyay, P., Mechirova, V., Pella, D., and Fedacko, J. Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study. Acta Cardiol. 20
- Cruciani, R. A., Dvorkin, E., Homel, P., Culliney, B., Malamud, S., Lapin, J., Portenoy, R. K., and Esteban-Cruciani, N. L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study. J Pa PubMed
- Malaguarnera, M., Vacante, M., Avitabile, T., Malaguarnera, M., Cammalleri, L., and Motta, M. L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes. Am J Clin.Nutr 2009;89(1):71-76. PubMed
- Alvarez, T. M., Guardiola, P. D., Roldan, J. O., Elviro, R., Wevers, R., and Guijarro, G. [Primary trimethylaminuria: the fish odor syndrome]. Endocrinol.Nutr. 2009;56(6):337-340.
- Wu, Z. M., Lu, X., Wang, Y. W., Sun, J., Tao, J. W., Yin, F. H., and Cheng, H. J. [Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia]. Zhonghua Nan.Ke.Xue 2012;18(3):253-256.
- Tarighat, Esfanjani A., Mahdavi, R., Ebrahimi, Mameghani M., Talebi, M., Nikniaz, Z., and Safaiyan, A. The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis. Biol.Trace Elem.Res 2012;150(1-3): PubMed
- DiNicolantonio, J. J., Lavie, C. J., Fares, H., Menezes, A. R., and O'Keefe, J. H. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Mayo Clin Proc. 2013;88(6):544-551. PubMed
- Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. B. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract
- Madsen KL, Preisler N, Orngreen MC, Andersen SP, Olesen JH, Lund AM, Vissing J. Patients with medium-chain acyl-coenzyme a dehydrogenase deficiency have impaired oxidation of fat during exercise but no effect of L-carnitine supplementation. J Clin Endocri
- Prohaska ES, Muzyk AJ, Rivelli SK. Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity. J Neuropsychiatry Clin Neurosci. 2012 Winter;24(1):E18-9. PubMed
- Shang R, Sun Z, Li H. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2014 Jul 21;14:88. PubMed
- Zhang JJ, Wu ZB, Cai YJ, Ke B, Huang YJ, Qiu CP, Yang YB, Shi LY, Qin J. L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled study. Nutr J. 2014 Nov 26;13:110. PubMed
- Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Intestinal microbiota metabolism of L-carn
- Jun DW, Kim BI, Cho YK, Kim HJ, Kwon YO, Park SY, Han SY, Baek YH, Jung YJ, Kim HY, Kim W, Heo J, Woo HY, Hwang SG, Rim KS, Choi JY, Bae SH, Lee YS, Lim YS,Cheong JY, Cho SW, Lee BS, Kim SH, Sohn JH, Kim TY, Paik YH, Kim JK, Lee KS. Efficacy and safety of
- An JH, Kim YJ, Kim KJ, et al. L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial. Endocr J. 2016;63(10):885-95. PubMed
- Chen N, Yang M, Zhou M, Xiao J, Guo J, He L. L-carnitine for cognitive enhancement in people without cognitive impairment. Cochrane Database Syst Rev. 2017;3:CD009374. PubMed
- Khajeh B, Dashti-Khavidaki S, Nasiri-Toosi M, Mohammadi K, Jafari A. Effects of pre-transplant L-carnitine supplementation on primary graft dysfunction in liver transplant recipients: a pilot, randomized, placebo-controlled clinical trial. Res Pharm Sci. PubMed
- Kubota K, Uojima H, Shao X, et al. Additional L-carnitine Reduced the Risk of Hospitalization in Patients with Overt Hepatic Encephalopathy on Rifaximin. Dig Dis 2021. PubMed
- Amini L, Yaghini O, Ghazavi M, Aslani N. L-carnitine versus propranolol for pediatric migraine prophylaxis. Iran J Child Neurol 2021;15(2):77-86.
- Shakibaei F, Jelvani D. Effect of adding l -carnitine to risperidone on behavioral, cognitive, social, and physical symptoms in children and adolescents with autism: A randomized double-blinded placebo-controlled clinical trial. Clin Neuropharmacol 2023;4 PubMed
- Moustafa I, Connolly C, Anis M, Mustafa H, Oosthuizen F, Viljoen M. A prospective study to evaluate the efficacy and safety of vitamin E and levocarnitine prophylaxis against doxorubicin-induced cardiotoxicity in adult breast cancer patients. J Oncol Phar PubMed
Cissus Quadrangularis 5 references
- Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
- Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
- Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
- Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
- Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed
See these in context on the Cissus Quadrangularis monograph →
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