Major interaction on record — check this product against your medications before combining. Based on 10 of 16 ingredients. Check your meds →
Dietary supplement

SuperSilica Plus! Ingredients & Drug Interactions

by Harmonic Innerprizes

SuperSilica Plus! label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SuperSilica Plus! against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

SuperSilica Plus! is a dietary supplement by Harmonic Innerprizes with 16 active ingredients. Its ingredients are commonly taken for hair, skin, and nail health, bone health and osteoporosis, joint and connective tissue support.Based on those ingredients, 549 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dandelion 4:1 extract, Horsetail extract, Nettles extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SuperSilica Plus! by Harmonic Innerprizes

Ask about any prescription or over-the-counter medication and we check it for interactions with SuperSilica Plus! by Harmonic Innerprizes — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SuperSilica Plus! by Harmonic Innerprizes

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 16 active ingredients.
  • “Proprietary Blend - Enzymes” is a proprietary blend — the label gives one combined amount (70 mg) without saying how much of each component you get.
  • “Proprietary Blend Herbal Extracts” is a proprietary blend — the label gives one combined amount (440 mg) without saying how much of each component you get.

SuperSilica Plus! contains 16 ingredients total. The active components include protease, lipase, and phytase — enzymes that help break down proteins, fats, and certain plant compounds — along with silica (a form of silicon), several herbal extracts (bamboo, horsetail, nettles, barley grass, dandelion, and yellow dock), and additional plant-based enzymes like glucoamylase, pectinase, and beta-glucanase.

These are combined in proprietary blends labeled as enzyme and herbal extract blends. The remaining ingredients are inactive fillers and binders: silica mineral complex and water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Hair, skin, nails, bones, and soft tissue health.
  • We looked for evidence on: Aging skin, Androgenic alopecia, Osteoporosis, Hair loss, Nail brittleness, Joint health.
  • The strongest evidence on file: Silicon is rated "Possibly Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Horsetail is rated "Insufficient Reliable Evidence To Rate" for Androgenic alopecia, Osteoporosis.
  • Also on file: Silicon is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Androgenic alopecia.

The evidence supporting this product is limited and mixed. Barley grass extract shows Likely Effective rating for lowering cholesterol and supporting heart health.

Silica is Possibly Effective for osteoporosis. For the other active ingredients — protease, lipase, phytase, horsetail, nettles, dandelion, bamboo, and yellow dock — the data we hold shows Insufficient Reliable Evidence for their intended uses, meaning we don't have solid proof they work for the purposes they're typically marketed for.

The evidence, ingredient by ingredient Silicon Proteolytic Enzymes (proteases) Lipase Phytase Bamboo Horsetail Stinging Nettle Barley

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the individual enzymes and herbs here are generally well tolerated in supplement form, though several come with cautions. Horsetail may cause abdominal distension, increased bowel movements, and nausea, and crude horsetail contains thiaminase which can lead to thiamine deficiency with long-term use.

Yellow dock acts as a laxative and contains oxalates; raw leaves or rhizomes can cause serious issues like kidney stones and low blood calcium. Dandelion may trigger diarrhea, heartburn, or stomach upset, and allergic reactions (including anaphylaxis) are rare but possible.

For pregnancy: protease, phytase, horsetail, nettles, dandelion, and yellow dock all lack sufficient safety data — the facts advise against them or against concentrated forms during pregnancy. Silica and bamboo extracts also should be avoided in pregnancy.

For breastfeeding, similar caution applies across most ingredients — check with your doctor first, especially for horsetail, nettles, dandelion, and yellow dock, which may pass compounds into milk.

Side effects, ingredient by ingredient Silicon Proteolytic Enzymes (proteases) Lipase Phytase Bamboo Horsetail Stinging Nettle Barley

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 10 matched ingredients can interact with medications — Bamboo, Yellow Dock, Stinging Nettle, Dandelion, Barley, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 549 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking SuperSilica Plus!, double-check with your pharmacist if you take diuretics (water pills), digoxin or other heart medications, blood thinners like warfarin, antidiabetes drugs, lithium, antithyroid medications, HIV medications (NRTIs or efavirenz), or fluoroquinolone antibiotics. Yellow dock and horsetail pose the highest risks here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product combines digestive enzymes with herbal extracts that carry real medication interactions, especially if you take heart medications, blood thinners, diabetes drugs, or lithium. If you're on any prescription medication, check it against our tool before starting.

Pregnant or nursing? Talk to your pharmacist or doctor — most of these ingredients lack the safety data needed to recommend them.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SuperSilica Plus!, straight from the product label.

Brand Harmonic Innerprizes
Barcode (UPC) 640627480603
Net contents 60 Vegicap(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 213232
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SuperSilica Plus! by Harmonic Innerprizes, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
UPC/BARCODE
640627480603
IngredientAmount% DV
Cellulose0 NP--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Glucoamylase0 NP--
Pectinase0 NP--
Beta-Glucanase0 NP--
Phytase0 NP--
Hemicellulase0 NP--
Silica85 mg--
Proprietary Blend - Enzymes70 mg--
Proprietary Blend Herbal Extracts440 mg--
Bamboo extract0 NP--
Horsetail extract0 NP--
Nettles extract0 NP--
organic Barley Grass extract0 NP--
Dandelion 4:1 extract0 NP--
Yellow Dock 4:1 extract0 NP--

Other ingredients: Silica Mineral Complex, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

SuperSilica Plus! Silica is a vital nutrient. It is a major component of hair, skin, nails, bones, and all the soft tissues of the body. Silica deficiency increases with age. Silica deficiency is a contributing factor in many age-related conditions such as increased brittleness of the skeletal system, chronically sore muscles and tendons, skin wrinkling, and even dementia.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition or are taking any medication.

Keep out of reach of children.

Formulation

Hypoallergenic: This product does not contain soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, yeast, salt, preservatives, artificial color, flavor, or fragrances.

Soft tissue integrity

Skeletal support series

Brand IP Statement(s)

2015 HarmonicInnerprizes, Inc.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, depending on your state of health or nutritional goals take 1 or 2 capsules daily preferably with meals.

General Statements

60 Vegicaps (500 mg ea)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SuperSilica Plus! by Harmonic Innerprizes label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SuperSilica Plus! label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SuperSilica Plus! by Harmonic Innerprizes

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Silica

No known
interactions
85 mg per serving Form: Bamboo, Horsetail

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for h...

Silica monograph & interactions

Proprietary Blend - Enzymes

70 mg per serving
  • › Cellulose
  • › Amylase
  • › Protease
  • › Lipase
  • › Glucoamylase
  • › Pectinase
  • › Beta-Glucanase
  • › Phytase
  • › Hemicellulase

Proprietary Blend Herbal Extracts

440 mg per serving

Other (inactive) ingredients: Silica Mineral Complex, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

SuperSilica Plus! by Harmonic Innerprizes Drug Interactions

Want to check YOUR meds against SuperSilica Plus!?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
549Drugs
76 Major 473 Moderate

Ingredients driving the most interactions

Dandelion 4:1 extract 457
Horsetail extract 188
Nettles extract 164
Yellow Dock 4:1 extract 78
Bamboo extract 5

Individual Drug Interactions

The ingredients in SuperSilica Plus! interact with 549 drugs. Click any drug to see the details.

6 of the 16 ingredients in SuperSilica Plus! interact with drugs. Each result below shows which ingredient is responsible. Dandelion 4:1 extract Horsetail extract Nettles extract Yellow Dock 4:1 extract Bamboo extract organic Barley Grass extract

Each ingredient & the kinds of drugs it affects

For each ingredient in SuperSilica Plus! with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dandelion 4:1 extract7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion 4:1 extract full monograph & interactions

Horsetail extract5 drug types · 188 drugs

Antidiabetes Drugs

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.

Likelihood Possible Evidence D
Efavirenz (Sustiva)

Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Nucleoside Reverse Transcriptase Inhibitors (Nrtis)

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Horsetail extract full monograph & interactions

Nettles extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettles extract full monograph & interactions

Yellow Dock 4:1 extract3 drug types · 78 drugs

Digoxin (Lanoxin)

Theoretically, yellow dock might increase the risk of digoxin toxicity when used long-term or in large amount.
When yellow dock is used chronically or in large amounts, hypokalemia may occur. This might increase the toxic effects of digoxin.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
When yellow dock is used chronically or in large amounts, hypokalemia may occur, and overuse of yellow dock might compound diuretic-induced potassium loss.

Likelihood Probable Evidence D
Warfarin (Coumadin)

Theoretically, the laxative effects of yellow dock might increase the effects of warfarin, including the risk of bleeding.
The anthraquinones in yellow dock have a mild stimulant laxative effect. Consuming excessive amounts can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Yellow Dock 4:1 extract full monograph & interactions

Bamboo extract1 drug type · 5 drugs

Antithyroid Drugs

Theoretically, long-term bamboo use might increase the effects and adverse effects of antithyroid drugs, possibly leading to hypothyroidism.
Animal research suggests that long-term consumption of bamboo shoot can decrease thyroid peroxidase activity, as well as levels of thyroxine (T4) and triiodothyronine (T3). This effect has not yet been reported in humans.

Likelihood Possible Evidence D
Bamboo extract full monograph & interactions

organic Barley Grass extract1 drug type · 1 drug

Triclabendazole (Egaten)

Theoretically, barley might decrease the clinical effects of triclabendazole.
Animal research suggests that a diet supplemented with barley can reduce the bioavailability of triclabendazole when taken concomitantly. This effect has not been shown in humans.

Likelihood Possible Evidence D
organic Barley Grass extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SuperSilica Plus!, from the product label.

Harmonic Innerprizes

See all Harmonic Innerprizes products
Name
Harmonic Innerprizes, Inc.
City
Henderson
State
NV
ZipCode
89053
Phone Number
1.888.667.4300
Web Address
Harmonicinnerprizes.com
Pharmacist Counseling Corner

SuperSilica Plus! by Harmonic Innerprizes: Common Questions

Does SuperSilica Plus! by Harmonic Innerprizes interact with any medications?
Yes. Based on its ingredients, SuperSilica Plus! has a known interaction with 549 medications, including 76 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SuperSilica Plus! contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually help with digestion?
The product contains digestive enzymes like protease, lipase, and phytase, but we don't have solid evidence these work for indigestion or other digestive problems when taken as supplements. The data on lipase and phytase effectiveness is insufficient to make a recommendation.
Is it safe to take if I'm pregnant?
No — most of the active ingredients here, including protease, horsetail, nettles, dandelion, yellow dock, bamboo, and silica, lack enough safety data during pregnancy. The facts advise against them. Talk with your doctor or pharmacist before taking it.
Can I take this while I'm breastfeeding?
There isn't enough safety data for most ingredients while breastfeeding — especially horsetail, nettles, dandelion, and yellow dock, which may pass compounds into milk. Check with your healthcare provider first.
What are the enzymes in this for?
Protease breaks down proteins, lipase breaks down fats, and phytase helps break down certain plant compounds. However, we don't have reliable evidence that taking them as supplements actually improves digestion or helps specific conditions.
Does this contain gluten?
The product contains barley grass extract, and barley does contain gluten, so this product is not suitable if you're sensitive to gluten or have celiac disease.
What's the silica in this supposed to do?
Silica (a form of silicon) is Possibly Effective for osteoporosis — meaning there's some evidence it may help — but the evidence for other uses listed in supplements is insufficient. It's generally well tolerated from food and most supplements, though long-term high-dose safety isn't well studied.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SuperSilica Plus! label
Go deeper

The Full Monographs Behind SuperSilica Plus!’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Phytase

Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...

Read the full Phytase monograph → Herb & supplement monograph

Bamboo

Interacts with 5 drugs

Bamboo is a giant grass whose shoots are eaten as food and whose leaves and silica-rich extracts are sold as supplements, often for hair, skin, nail, and bone support. Solid human evidence f...

Read the full Bamboo monograph → Herb & supplement monograph

Horsetail

Interacts with 188 drugs

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...

Read the full Horsetail monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Barley

Interacts with 1 drug

Barley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad') cholesterol when eaten regularly. It...

Read the full Barley monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Yellow Dock

Interacts with 78 drugs

Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefits are largely unproven, and its natural...

Read the full Yellow Dock monograph →
Sources

Sources & How We Checked

SuperSilica Plus!'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 121 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
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Silicon 19 references
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Bamboo 4 references
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Horsetail 14 references
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Stinging Nettle 23 references
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Barley 15 references
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Dandelion 27 references
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Yellow Dock 8 references
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