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Dietary supplement

Tocotrienols Ingredients & Drug Interactions

by Pure Encapsulations

Tocotrienols label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tocotrienols against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Tocotrienols is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 122 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Mixed Tocotrienols/Tocopherols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tocotrienols by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Tocotrienols by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tocotrienols by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a blend of tocotrienols and tocopherols, which are forms of vitamin E. Tocotrienols are a group of compounds that your body can use similarly to the more common tocopherol form of vitamin E.

The capsule itself is made from gelatin, which is an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Tocotrienols's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Cardiovascular and antioxidant support.
  • We looked for evidence on: Hypercholesterolemia, Metabolic syndrome, Nonalcoholic fatty liver disease (NAFLD), Stroke, Heart health, Cholesterol management — and 2 related terms.
  • The closest evidence on file: Tocotrienols is rated "Possibly Ineffective" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Tocotrienols is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Stroke, Metabolic syndrome.

The evidence for tocotrienols is mixed and limited. For blood sugar control in diabetes, the data suggests it may be effective — but the evidence isn't yet solid.

For high cholesterol, the research suggests it's likely not effective. For hair loss (alopecia areata) and breast cancer, we don't have enough reliable evidence to know either way.

If you're considering this supplement for one of those conditions, talk with your doctor about whether the current evidence supports trying it.

The evidence, ingredient by ingredient Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tocotrienols are generally well tolerated when taken by mouth, and no adverse effects were reported in clinical trials. However, long-term safety at supplement doses hasn't been fully studied.

If you're pregnant, there isn't enough safety information, so it's best to avoid it — talk with your doctor or pharmacist for personalized advice. While breastfeeding, safety data is limited, so unless your doctor advises it, skip the supplement and discuss it with them first.

Side effects, ingredient by ingredient Tocotrienols

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tocotrienols.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on any blood thinners or antiplatelet drugs — medications like warfarin, clopidogrel, or aspirin. Tocotrienols may theoretically increase bleeding risk with these drugs, though it hasn't been reported in people.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Tocotrienols might be worth considering if you have diabetes and want to explore options beyond standard care, but the evidence is still developing. If you take blood thinners or antiplatelet medications, check with your pharmacist before starting.

Pregnant or nursing? Talk to your doctor first — the safety data isn't there yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tocotrienols, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298002866
Net contents 60 Softgel Capsule(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 185259
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tocotrienols by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel Capsule(s)
Maximum serving Sizes:
1 Softgel Capsule(s)
Servings per container
60
UPC/BARCODE
766298002866
IngredientAmount% DV
Mixed Tocotrienols/Tocopherols60 mg--

Other ingredients: Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 1-2 times daily, with meals.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Scan to learn about our hypoallergenic supplements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Cardiovascular and antioxidant support

Contents may appear cloudy.

Formulation

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

v7 code: TO6

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tocotrienols by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tocotrienols label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tocotrienols by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Mixed Tocotrienols/Tocopherols

Interacts with
122 drugs
60 mg per serving Form: Rice bran oil

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

Mixed Tocotrienols/Tocopherols monograph & interactions

Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tocotrienols by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Tocotrienols?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Minor

Ingredients driving the most interactions

Mixed Tocotrienols/Tocopherols 122

Individual Drug Interactions

The ingredients in Tocotrienols interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tocotrienols interact with drugs. Each result below shows which ingredient is responsible. Mixed Tocotrienols/Tocopherols

Each ingredient & the kinds of drugs it affects

For each ingredient in Tocotrienols with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mixed Tocotrienols/Tocopherols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Mixed Tocotrienols/Tocopherols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tocotrienols, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Tocotrienols by Pure Encapsulations: Common Questions

Does Tocotrienols by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Tocotrienols has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tocotrienols contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is tocotrienol, and how is it different from regular vitamin E?
Tocotrienols are a form of vitamin E, similar in function to the more common form called tocopherols. Both are compounds your body can use, but tocotrienols have a slightly different structure. This product contains a mix of both.
Can this help me lose weight or manage my metabolism?
The data we have doesn't cover weight loss or metabolism. The evidence looks at diabetes control, cholesterol, hair loss, and cancer — those are the areas where research has been done. If weight management is your goal, talk with your doctor about proven approaches.
Is this safe to take long-term?
Tocotrienols appear well tolerated in studies with no reported side effects when taken by mouth. However, long-term safety at supplement doses hasn't been fully established, so it's worth discussing with your pharmacist if you plan to use it for months or years.
Can I take this if I'm pregnant or breastfeeding?
If you're pregnant, there isn't enough safety information, so it's best to avoid it — talk with your doctor. While breastfeeding, safety data is limited as well, so check with your doctor before taking it unless they specifically advise it.
What are the side effects?
Taken by mouth, tocotrienols haven't caused any adverse effects in clinical trials. If applied to skin as a cream, mild itching was reported in a small number of trial participants, though it's unclear whether that came from tocotrienols alone or the combination of ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tocotrienols is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tocotrienols label
Go deeper

The Full Monographs Behind Tocotrienols’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

Tocotrienols's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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