Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Zydenafil Ingredients & Drug Interactions

by Ideal Performance

Zydenafil label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zydenafil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zydenafil is a dietary supplement by Ideal Performance with 8 active ingredients. Its ingredients are commonly taken for low testosterone or male vitality, sexual performance and libido support, athletic performance and muscle building.Based on those ingredients, 1,076 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed Leaf Extract, Tongkat Ali, Powder, Saw Palmetto Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Zydenafil by Ideal Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with Zydenafil by Ideal Performance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zydenafil by Ideal Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Test Boost Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,200 mg) without saying how much of each component you get.

Zydenafil contains 8 ingredients, most of which are herbal extracts. The active ingredients are orchic substance (derived from bovine testes), saw palmetto fruit extract, boron amino acid chelate, wild yam root extract, horny goat weed leaf extract, tongkat ali powder, nettle root extract, and sarsaparilla.

The product also includes a "Test Boost Proprietary Blend"—a group ingredient whose individual components are listed separately. Inactive ingredients include calcium carbonate, microcrystalline cellulose, sodium starch glycolate, stearic acid, magnesium stearate, silicon dioxide, and gelatin (the capsule material).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Male advanced support.
  • We looked for evidence on: Age-related testosterone deficiency, Benign prostatic hyperplasia (BPH), Erectile dysfunction (ED), Male infertility, Sexual desire, Sexual dysfunction — and 4 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Stinging Nettle is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH).

The evidence for most ingredients in Zydenafil is limited. Saw palmetto shows possibly ineffective evidence for benign prostate symptoms and possibly effective evidence only for a specific urological procedure (TURP); for most other uses the evidence is insufficient.

Boron is possibly effective for vaginal yeast infections and radiation burns, and likely effective for boron deficiency. Wild yam is possibly ineffective for menopause symptoms, with insufficient evidence for other uses.

Horny goat weed, tongkat ali, nettle root, and sarsaparilla all lack sufficient reliable evidence for the conditions they're traditionally used for—the data we hold rates them as insufficient to establish effectiveness. Orchic substance has no effectiveness ratings in our data.

Overall, the ingredients lack strong evidence for most of their claimed benefits.

The evidence, ingredient by ingredient Orchic Extract Saw Palmetto Boron Wild Yam Horny Goat Weed Eurycoma Longifolia Stinging Nettle Sarsaparilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses, but several carry cautions or safety concerns. Orchic substance comes from raw bovine testes and carries contamination risks; there's no human safety data, so it should be avoided in pregnancy and while breastfeeding.

Saw palmetto is well tolerated orally with mild, reversible side effects (abdominal pain, constipation, decreased libido, diarrhea, dizziness, fatigue, headache, nausea, rhinitis, vomiting), though rare cases of heart rhythm problems and a fixed drug eruption have been reported. Boron is safe below 20 mg daily but toxic at high doses; it should be avoided in pregnancy and while breastfeeding.

Wild yam, horny goat weed, tongkat ali, nettle root, and sarsaparilla all lack sufficient pregnancy and breastfeeding safety data and should be avoided during both. Horny goat weed may cause dizziness, dry mouth, nosebleed, thirst, and vomiting; nettle root may cause constipation or diarrhea.

Nettle root has rare case reports of liver injury with herbal combinations. Tongkat ali may raise testosterone and bring testosterone-related side effects if levels go too high.

Side effects, ingredient by ingredient Orchic Extract Saw Palmetto Boron Wild Yam Horny Goat Weed Eurycoma Longifolia Stinging Nettle Sarsaparilla

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Sarsaparilla, Stinging Nettle, Horny Goat Weed, Wild Yam, Saw Palmetto, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,077 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Zydenafil, double-check with your doctor or pharmacist if you take any of the following: blood thinners or antiplatelet drugs (saw palmetto and horny goat weed increase bleeding risk), estrogens or birth control pills (saw palmetto, wild yam, and horny goat weed may reduce effectiveness), blood pressure medications (horny goat weed may lower blood pressure further), diabetes medications (nettle root may add to blood sugar lowering), water pills (nettle root and sarsaparilla may have additive effects), lithium (nettle root and sarsaparilla may increase levels), warfarin (nettle root's vitamin K may interfere), digoxin (sarsaparilla may increase toxicity risk), propranolol (tongkat ali reduces effectiveness), or any medications broken down by your liver's CYP1A2, CYP2B6, CYP2C19, CYP2A6, or CYP3A4 enzymes (horny goat weed and tongkat ali may raise levels).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Zydenafil is a multi-ingredient supplement with herbs traditionally linked to sexual performance and prostate health, but the evidence for most ingredients is weak or absent. Because it contains ingredients that interact with blood thinners, birth control, blood pressure medications, blood sugar drugs, heart medications, lithium, and several enzyme systems your body uses to clear drugs, you'll need to check each of your medications against this product before starting it.

Talk with your doctor or pharmacist about whether it's right for you and whether any of your prescriptions or over-the-counter drugs could be affected.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zydenafil, straight from the product label.

Brand Ideal Performance
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 304611
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zydenafil by Ideal Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Orchic Substance0 NP--
Saw Palmetto Fruit Extract0 NP--
Boron Amino Acid Chelate0 NP--
Wild Yam Root Extract0 NP--
Test Boost Proprietary Blend1200 mg--
Horny Goat Weed Leaf Extract0 NP--
Tongkat Ali, Powder0 NP--
Nettle Root Extract0 NP--
Sarsaparilla0 NP--

Other ingredients: Calcium Carbonate, Microcrystalline Cellulose, Sodium Starch Glycolate, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement take 2 capsules daily, or as directed by a healthcare professional.

Precautions

Warning: For healthy individuals 18 years and older. Keep out of reach of children.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Do not exceed recommended dose. Do not use if safety seal is broken or missing.

Warning: Not intended for use by persons under 18 years of age. Keep this and all drugs out of children's reach.

Do not take product if you are pregnant or nursing.

Storage

Notice: Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Zydenafil 1200 mg

Male advanced support

Advanced formulation includes Tongkat Ali, Maca, Tribulus Terrestris, Nettle, L-Arginine, Panax Ginseng, Eleutherococcus, Zinc

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Tested 3rd Party Certified Pure Potency Made in USA GMP Good Manufacturing Practice Facility Made in a FDA Facility

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zydenafil by Ideal Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zydenafil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zydenafil by Ideal Performance

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Calcium Carbonate, Microcrystalline Cellulose, Sodium Starch Glycolate, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zydenafil by Ideal Performance Drug Interactions

Want to check YOUR meds against Zydenafil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,076Drugs
1,052 Moderate 24 Minor

Ingredients driving the most interactions

Horny Goat Weed Leaf Extract 963
Tongkat Ali, Powder 248
Saw Palmetto Fruit Extract 174
Nettle Root Extract 164
Wild Yam Root Extract 41

Individual Drug Interactions

The ingredients in Zydenafil interact with 1,076 drugs. Click any drug to see the details.

6 of the 8 ingredients in Zydenafil interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed Leaf Extract Tongkat Ali, Powder Saw Palmetto Fruit Extract Nettle Root Extract Wild Yam Root Extract Sarsaparilla

Each ingredient & the kinds of drugs it affects

For each ingredient in Zydenafil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed Leaf Extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed Leaf Extract full monograph & interactions

Tongkat Ali, Powder5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali, Powder full monograph & interactions

Saw Palmetto Fruit Extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto Fruit Extract full monograph & interactions

Nettle Root Extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettle Root Extract full monograph & interactions

Wild Yam Root Extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam Root Extract full monograph & interactions

Sarsaparilla2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zydenafil, from the product label.

Ideal Performance

See all Ideal Performance products
Name
Ideal Performance
City
Farmingdale
State
TY
ZipCode
11735
Pharmacist Counseling Corner

Zydenafil by Ideal Performance: Common Questions

Does Zydenafil by Ideal Performance interact with any medications?
Yes. Based on its ingredients, Zydenafil has a known interaction with 1,076 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zydenafil contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Zydenafil if I'm pregnant or breastfeeding?
No. Saw palmetto, wild yam, horny goat weed, tongkat ali, nettle root, and sarsaparilla all lack safety data in pregnancy and should be avoided; nettle root is rated likely unsafe in pregnancy. Orchic substance and boron also have no established safety in pregnancy or while breastfeeding. Talk with your doctor before considering this product if you're pregnant, planning to become pregnant, or breastfeeding.
What is orchic substance?
Orchic substance is an extract made from raw bovine (cow) testes. The safety and quality concerns are significant: products may contain tissue from diseased animals, there's a theoretical risk of contamination with mad cow disease (BSE) if sourced from affected countries, and human safety data is very limited. No cases of BSE transfer to humans from orchic products have been reported, but the source quality remains a concern.
Does Zydenafil actually work for sexual performance?
The evidence doesn't support most ingredients for sexual function. Tongkat ali shows possibly effective evidence for sexual desire, but horny goat weed, nettle root, sarsaparilla, and orchic substance all lack sufficient reliable evidence to establish effectiveness for sexual health.
What are the most common side effects?
Saw palmetto most commonly causes abdominal pain, constipation, diarrhea, dizziness, fatigue, headache, nausea, and decreased libido. Horny goat weed may cause dizziness, dry mouth, nosebleed, thirst, and vomiting. Nettle root may cause constipation or diarrhea. Most side effects from these ingredients are mild and reversible, but you should stop and contact your doctor if you experience anything concerning.
Is Zydenafil safe to combine with my other supplements or medications?
That depends entirely on what you're taking. This product interacts with over 1,000 individual medications across multiple categories—blood thinners, birth control, blood pressure drugs, diabetes medications, heart medications, and many others. Use the medication checker on this page to search your exact prescriptions and supplements before taking Zydenafil, and confirm with your doctor or pharmacist.
Why does this product have so many interactions?
Several of its ingredients affect enzymes your liver uses to break down medications, or they have hormone-like effects that can interfere with estrogens, blood pressure, bleeding, and blood sugar control. Even though individual interactions are rated Moderate or Minor, the large number of ingredients and their broad mechanisms mean many drugs can be affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zydenafil is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zydenafil label
Go deeper

The Full Monographs Behind Zydenafil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Orchic Extract

Orchic extract is a glandular supplement made from the testicle tissue of animals, usually cattle. It is marketed for testosterone and male vitality, but there is essentially no reliable hum...

Read the full Orchic Extract monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph →
Sources

Sources & How We Checked

Zydenafil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 78 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Orchic Extract 2 references
  1. ORCHIC PMG (Protomorphogen). Natural Health Cod. www.nbizz.com/naturalhealthdoc/listings/184.html (Accessed 9 November 2000).
  2. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.

See these in context on the Orchic Extract monograph →

Saw Palmetto 22 references
  1. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
  2. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
  3. Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
  4. Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
  5. Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
  6. Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
  7. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  8. Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
  9. Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
  10. Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
  11. Agbabiaka, T. B., Pittler, M. H., Wider, B., and Ernst, E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009;32(8):637-647. PubMed
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Boron 6 references
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Wild Yam 7 references
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Horny Goat Weed 11 references
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Eurycoma Longifolia 4 references
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Stinging Nettle 23 references
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Sarsaparilla 3 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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