Bexarotene

Name: Bexarotene Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

86 interactions 92 cited references

Also sold as: Targretin Targretin® Capsules

About Bexarotene

Bexarotene is used to treat cutaneous T-cell lymphoma (CTCL, a type of skin cancer) in people whose disease could not be treated successfully with at least one other medication. Bexarotene is in a class of medications called retinoids. It works by stopping the growth of cancer cells. Read the full Bexarotene drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Ranolazine Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live

10 Contraindicated 63 Major 13 Moderate

All (86) Contraindicated (10) Major (63) Moderate (13)

Moderate

Bexarotene Phenobarbital Fidoquel Decreased plasma levels of bexarotene Details Bexarotene Phenytoin Dilantin Decreased plasma levels of bexarotene Details Bexarotene Rifampin Rifadin Decreased plasma levels of bexarotene Details Bexarotene Vitamin A Aquasol A An increased risk of retinoid toxicity Details Bexarotene Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details Bexarotene Ketoconazole Topical Extina® Foam Increased bexarotene exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.