Bexarotene

86 interactions 92 cited references
Also sold as: Targretin Targretin® Capsules
About Bexarotene

Bexarotene is used to treat cutaneous T-cell lymphoma (CTCL, a type of skin cancer) in people whose disease could not be treated successfully with at least one other medication. Bexarotene is in a class of medications called retinoids. It works by stopping the growth of cancer cells. Read the full Bexarotene drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Ranolazine Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live
10 Contraindicated 63 Major 13 Moderate
All (86) Contraindicated (10) Major (63) Moderate (13)

Major

Bexarotene Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Bexarotene Mestranol Decreased contraceptive effectiveness Details Bexarotene Methacycline An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Methotrexate Jylamvo An increased risk of hepatotoxicity, an increased methotrexate exposure, an increased risk of methotrexate-related severe adverse... Details Bexarotene Minocycline Amzeeq An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Nifedipine Adalat® Reduced NIFEdipine exposure Details Bexarotene Nomegestrol Decreased contraceptive effectiveness Details Bexarotene Norelgestromin Decreased contraceptive effectiveness Details Bexarotene Norethindrone Aygestin Decreased contraceptive effectiveness Details Bexarotene Norgestimate Decreased contraceptive effectiveness Details Bexarotene Norgestrel Decreased contraceptive effectiveness Details Bexarotene Oliceridine Olinvyk Reduced oliceridine exposure and reduced efficacy of oliceridine Details Bexarotene Omadacycline Nuzyra An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Oxytetracycline An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Palovarotene Sohonos Increased risk of hypervitaminosis A Details Bexarotene Rolitetracycline An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Bexarotene Sarecycline Seysara An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Segesterone Decreased contraceptive effectiveness Details Bexarotene Tetracycline Achromycin V® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Tigecycline Tygacil An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Tramadol ConZip Reduced traMADol exposure and reduced efficacy of traMADol Details Bexarotene Ulipristal Ella Decreased contraceptive effectiveness Details Bexarotene Voriconazole Vfend Reduced voriconazole exposure and an reduced efficacy of voriconazole Details Bexarotene Doxycycline Injection Acticlate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Eravacycline Injection Xerava An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Estradiol Topical Divigel Decreased contraceptive effectiveness Details Bexarotene Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Bexarotene Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Bexarotene Medroxyprogesterone Injection Depo-Provera Decreased contraceptive effectiveness Details Bexarotene Methotrexate Injection Abitrexate® An increased risk of hepatotoxicity, an increased methotrexate exposure, an increased risk of methotrexate-related severe adverse... Details Bexarotene Minocycline Topical Amzeeq An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Bexarotene Omadacycline Injection Nuzyra An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Moderate

Bexarotene Atorvastatin Atorvaliq Decreased atorvastatin plasma concentrations Details Bexarotene Artemether Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details Bexarotene Erythromycin Erythrocin Stearate Increased bexarotene exposure Details Bexarotene Fosphenytoin Cerebyx Decreased plasma levels of bexarotene Details Bexarotene Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Bexarotene Ketoconazole Extina Increased bexarotene exposure Details Bexarotene Lumefantrine Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine and loss of antimalarial efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.