Cenobamate

54 interactions 4 explained in plain English
Also sold as: Xcopri
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Cenobamate Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Cenobamate Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Cenobamate Atogepant Qulipta Reduced atogepant exposure Details Cenobamate Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Cenobamate Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Cenobamate Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Cenobamate Amlodipine Amvaz® Reduced amLODIPine exposure Details Cenobamate Bedaquiline Sirturo Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Cenobamate Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cenobamate Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cenobamate Capmatinib Tabrecta Decreased capmatinib exposure and reduction of antitumor activity Details Cenobamate Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Cenobamate Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Cenobamate Doravirine Pifeltro Reduced doravirine exposure and reduced efficacy of doravirine Details Cenobamate Elacestrant Orserdu Reduced elacestrant exposure and reduced efficacy of elacestrant Details Cenobamate Encorafenib Braftovi Reduced encorafenib exposure and reduced efficacy of encorafenib Details Cenobamate Entrectinib Rozlytrek Reduced entrectinib exposure and reduced efficacy of entrectinib Details Cenobamate Erdafitinib Balversa Reduced erdafitinib exposure Details Cenobamate Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Cenobamate Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Cenobamate Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Cenobamate Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Cenobamate Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Cenobamate Glasdegib Daurismo Reduced glasdegib exposure Details Cenobamate Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Cenobamate Ibrexafungerp Brexafemme Decreased ibrexafungerp plasma concentrations Details Cenobamate Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Cenobamate Lefamulin Xenleta Reduced lefamulin exposure and reduced efficacy of lefamulin Details Cenobamate Lenacapavir Injection Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Cenobamate Lenacapavir Oral Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Cenobamate Leniolisib Joenja Reduced leniolisib exposure and reduced efficacy of leniolisib Details Cenobamate Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Cenobamate Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Cenobamate Lumateperone Caplyta Reduced lumateperone exposure Details Cenobamate Lurasidone Latuda Reduced lurasidone exposure Details Cenobamate Medroxyprogesterone Amen® Reduced medroxyPROGESTERone exposure Details Cenobamate Medroxyprogesterone Injection Depo-Provera Reduced medroxyPROGESTERone exposure Details Cenobamate Mitapivat Aqvesme Reduced mitapivat exposure and reduced efficacy of mitapivat Details Cenobamate Neratinib Nerlynx Decreased exposure of neratinib and risk of reduced efficacy Details Cenobamate Nifedipine Adalat® Reduced NIFEdipine exposure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.