Cetirizine

21 interactions 2 explained in plain English
Also sold as: Aller-Tec Alleroff Quzyttir Wal Zyr 24 Hour Allergy Wal-Zyr Zyrtec
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Diphenhydramine Injection Morphine Injection Midazolam Nasal Spray Butorphanol Injection Butorphanol Nasal Spray
20 Major 1 Moderate
All (21) Major (20) Moderate (1)

Major

Cetirizine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of CNS depression Details Cetirizine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Cetirizine Aripiprazole Injection Abilify Increased risk of CNS depression Details Cetirizine Asenapine Transdermal Patch Secuado Increased risk of CNS depression Details Cetirizine Butorphanol Injection Butorphic Increased risk of CNS depression Details Cetirizine Butorphanol Nasal Spray Stadol® NS Increased risk of CNS depression Details Cetirizine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Cetirizine Diazepam Rectal Diastat Increased risk of CNS depression Details Cetirizine Diphenhydramine Injection Banophen Increased risk of CNS depression Details Cetirizine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Cetirizine Esketamine Nasal Spray Spravato Increased risk of CNS depression Details Cetirizine Fentanyl Transdermal Patch Duragesic® Increased risk of CNS depression Details Cetirizine Hydromorphone Injection Dilaudid Increased risk of CNS depression Details Cetirizine Hydromorphone Rectal available generically Increased risk of CNS depression Details Cetirizine Lacosamide Injection Motpoly An increased risk of CNS depression Details Cetirizine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Cetirizine Midazolam Nasal Spray Nayzilam Increased risk of CNS depression Details Cetirizine Midazolam Injection Nayzilam Increased risk of CNS depression Details Cetirizine Morphine Injection Astramorph® PF Increased risk of CNS depression Details Cetirizine Nalbuphine Injection Nubain® Increased risk of CNS depression Details

Moderate

Cetirizine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.