Fluticasone

14 interactions
Also sold as: Aller-Flo Armonair Arnuity Beser Clarispray Cutivate Flonase Flonase Sensimist Flovent Fluticare Nasopro 24 Xhance

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Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Aspirin Aspirin Rectal Encorafenib Ketoconazole Topical Lefamulin
1 Contraindicated 11 Major 2 Moderate
All (14) Contraindicated (1) Major (11) Moderate (2)

Contraindicated

Fluticasone Desmopressin Nasal Concentraid® Increased risk of severe hyponatremia Details

Major

Fluticasone Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Fluticasone Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Fluticasone Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Fluticasone Ketoconazole Topical Extina® Foam Increased fluticasone exposure and an increased risk of cardiovascular effects Details Fluticasone Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Fluticasone Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of Cushing's syndrome and adrenal suppression Details Fluticasone Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of Cushing's syndrome and adrenal suppression Details Fluticasone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Fluticasone Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Fluticasone Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia, an increased risk of clinically significant cardiovascular effects and fatalities and an increas... Details Fluticasone Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details

Moderate

Fluticasone Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Fluticasone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.