Nitrazepam

22 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Midazolam Injection Diazepam Rectal Aripiprazole Injection Nalbuphine Injection Esketamine Nasal Spray Cetirizine Injection
21 Major 1 Moderate
All (22) Major (21) Moderate (1)

Major

Nitrazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Nitrazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Nitrazepam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Nitrazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Nitrazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Nitrazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Nitrazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Nitrazepam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Nitrazepam Diazepam Rectal Diastat Increased risk of CNS depression Details Nitrazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Nitrazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Nitrazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Nitrazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Nitrazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Nitrazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Nitrazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Nitrazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Nitrazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Nitrazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Nitrazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Nitrazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Nitrazepam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.