Pentazocine
41 interactions 4 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Granisetron Transdermal Patch
Lacosamide Injection
Diazepam Nasal Spray
Morphine Injection
Fentanyl Transdermal Patch
Midazolam Nasal Spray
Major
Pentazocine Acetaminophen And Codeine Capital® & Codeine Explained Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Pentazocine Amitriptyline Elavil Explained Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Pentazocine Sertraline Explained Increased risk of serotonin syndrome Details Pentazocine Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome and respiratory depr... Details Pentazocine Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Pentazocine Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Pentazocine Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Pentazocine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Pentazocine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Pentazocine Cyclosporine Injection Atopica Increased pentazocine plasma concentrations and increased risk of respiratory depression Details Pentazocine Cyclosporine Ophthalmic Cequa Increased pentazocine plasma concentrations and increased risk of respiratory depression Details Pentazocine Dexamethasone Injection Decadron Reduced pentazocine plasma concentrations Details Pentazocine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced pentazocine plasma concentrations Details Pentazocine Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Pentazocine Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Pentazocine Diphenhydramine Injection Banophen Increased risk of respiratory and CNS depression; increased risk of paralytic ileus Details Pentazocine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of respiratory and CNS depression; increased risk of paralytic ileus Details Pentazocine Dolasetron Anzemet Increased risk of serotonin syndrome Details Pentazocine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Pentazocine Esketamine Nasal Spray Spravato Increased risk of sedation Details Pentazocine Fentanyl Transdermal Patch Duragesic® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Pentazocine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Pentazocine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Pentazocine Hydromorphone Injection Dilaudid Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Pentazocine Hydromorphone Rectal available generically Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Pentazocine Hydroxychloroquine Plaquenil An increased risk of seizures Details Pentazocine Ketoconazole Topical Extina® Foam Increased pentazocine plasma concentrations and increased risk of respiratory depression Details Pentazocine Lacosamide Injection Motpoly An increased risk of CNS depression Details Pentazocine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Pentazocine Linezolid Injection Zyvox Increased risk of serotonin syndrome or opioid toxicity Details Pentazocine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Pentazocine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Pentazocine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Pentazocine Midazolam Nasal Spray Nayzilam Increased risk of respiratory and CNS depression Details Pentazocine Midazolam Injection Nayzilam Increased risk of respiratory and CNS depression Details Pentazocine Morphine Injection Astramorph® PF Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Pentazocine Nafcillin Injection Unipen® Injection Reduced pentazocine plasma concentrations Details Pentazocine Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Pentazocine Nevirapine Viramune Reduced pentazocine plasma concentrations Details Pentazocine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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