Zonisamide

Name: Zonisamide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

7 interactions

Also sold as: Zonegran Zonegran® Zonisade

About Zonisamide

Zonisamide is used in combination with other medications to treat certain types of seizures. Zonisamide is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain. Read the full Zonisamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Calcifediol Hydroxychloroquine Metformin Methotrexate Methotrexate Injection Orlistat

6 Major 1 Moderate

All (7) Major (6) Moderate (1)

Major

Zonisamide Calcifediol Rayaldee Altered serum levels of calcifediol Details Zonisamide Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Zonisamide Metformin Fortamet® An increased risk of lactic acidosis and reduced serum bicarbonate Details Zonisamide Methotrexate Jylamvo Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Zonisamide Methotrexate Injection Abitrexate® Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Zonisamide Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Zonisamide Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.