Drug & supplement interaction

Andiroba + Ingenol Mebutate

Ingenol Mebutate brand name: Picato.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Andiroba and Ingenol Mebutate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Andiroba and Ingenol Mebutate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ingenol Mebutate and Andiroba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Andiroba safety at a glance

Andiroba overall Use caution Generally used on the skin; safety of taking it internally is not well studied.

Pregnancy Avoid Not enough safety data; best to avoid during pregnancy.

Breastfeeding Avoid Not enough safety data; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ingenol Mebutate and Andiroba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Ingenol Mebutate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ingenol Mebutate is filed under a single classification — topical drugs. Andiroba has documented interactions with 1 drug class — the most serious being anticonvulsants (minor) — and none of Ingenol Mebutate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Andiroba Does Interact With Other Medications

Andiroba has 50 minor known drug interactions in our database — Ingenol Mebutate isn’t one of them. If you take anything else, check it against the full list below.

Minor 50 No known interaction 2,780 (incl. Ingenol Mebutate)

Taking anything else?

Check Another of Your Medications Against Andiroba

Covers the 2,830 medications we’ve checked against Andiroba. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ingenol Mebutate

This page covers Andiroba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ingenol Mebutate page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Ingenol Mebutate page

“Ingenol mebutate (Picato) is a gel applied to the skin for actinic keratosis, the rough precancerous patches caused by sun damage, and it is deliberately harsh, producing redness, flaking, and stinging as part of how it works. The few supplement interactions on record are all skin-level ones.”

Reviewed by 2 · Jul 18, 2026

Open the Ingenol Mebutate interaction page

How much people look this up

Where Andiroba and Ingenol Mebutate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andiroba

Steady interest

#1,042 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Ingenol Mebutate

Top half

#1,070 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Andiroba is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andiroba reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Andiroba and Ingenol Mebutate records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Andiroba

What is Andiroba?

Skin care and wound healing
Insect repellent
Muscle and joint aches
Anti-inflammatory skin conditions
Hair and scalp care

Andiroba is an oil pressed from the seeds of an Amazonian tree, used mainly on the skin for inflammation, minor wounds, aches, and as an insect repellent. Most evidence comes from laboratory and animal studies, so its benefits in people are not well proven. It is most often used topically; avoid internal use and use during pregnancy or breastfeeding because safety has not been established.

Carapa guianensis · Meliaceae · Seed oil (mainly), bark, and leaves · Topical oil, skin and hair products, soaps, balms, candles (insect repellent)

An interaction check asks whether these two react with each other — it does not ask whether Andiroba is a good idea for someone in your situation. Here is what our Andiroba record says about it on its own.

Andiroba: dosing

There is no established standard dose for andiroba. Doses have not been confirmed in reliable human studies.For topical products, follow the directions on the label.

From our Andiroba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Andiroba monograph & all interactions

Medication

About Ingenol Mebutate Topical

What Is Ingenol Mebutate Topical Used For?

Brand name: Picato

Ingenol mebutate gel is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Ingenol mebutate is in a class of medications called cytotoxic agents. It works by killing fast-growing cells such as the abnormal cells associated with actinic keratoses.

See full Ingenol Mebutate Topical drug information

Keep checking

Other Drugs & Andiroba

Browse every other medication we’ve checked against Andiroba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

50Minor

2,779No known interaction

50 Minor 2,779 No interaction

Minor

50 interactions

No interaction 2,779 drugs checked — show the list

We also checked Andiroba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,779 medications checked with no known interaction — see the full Andiroba list.

See the full Andiroba interactions page

See every supplement checked against Ingenol Mebutate, ranked by severity

Evidence & sources

Andiroba References

The 3 sources that drive our Andiroba monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Andiroba is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Carapa guianensis (Andiroba) — U.S. National Library of Medicine (PubChem / NCBI) Source
Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Using Dietary Supplements Safely — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Andiroba and Ingenol Mebutate Together: Common Questions

Is it safe to take Andiroba with Ingenol Mebutate?

We do not list a known interaction between Andiroba and Ingenol Mebutate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Andiroba and Ingenol Mebutate combination checked?

Interactions in our licensed database are recorded against drug classes. Ingenol Mebutate is filed under 1 classification, and Andiroba has documented interactions with 1 drug class — none of Ingenol Mebutate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Andiroba interact with any other medications?

Yes. Andiroba has 50 documented drug interactions in our database — Ingenol Mebutate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Ingenol Mebutate interact with any supplements?

Yes. Ingenol Mebutate has documented interactions with 3 supplements in our database — Andiroba is not one of them. The Ingenol Mebutate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Andiroba monograph Uses, safety profile, and every drug interaction in one place Ingenol Mebutate Topical drug information The full plain-English guide to this medication Ingenol Mebutate supplement interactions Every supplement checked against Ingenol Mebutate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ingenol Mebutate and Andiroba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.