Drug & supplement interaction

Andiroba + Palifermin

Palifermin brand name: Kepivance.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Andiroba and Palifermin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Andiroba and Palifermin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Palifermin and Andiroba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Andiroba safety at a glance

Andiroba overall Use caution Generally used on the skin; safety of taking it internally is not well studied.
Pregnancy Avoid Not enough safety data; best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Palifermin and Andiroba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Palifermin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Palifermin is filed under a single classification — oral drugs. Andiroba has documented interactions with 1 drug class — the most serious being anticonvulsants (minor) — and none of Palifermin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Andiroba Does Interact With Other Medications

Andiroba has 50 minor known drug interactions in our database — Palifermin isn’t one of them. If you take anything else, check it against the full list below.

Minor 50 No known interaction 2,780 (incl. Palifermin)
Taking anything else?

Check Another of Your Medications Against Andiroba

Covers the 2,830 medications we’ve checked against Andiroba. Pick one to open its full report.

What to actually watch for

What Palifermin’s Own FDA Label Lists

This is not an interaction — none of it involves Andiroba. These are the most notable effects listed in the ADVERSE REACTIONS section of Palifermin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on mentioned in 6.2% of FDA reports for Palifermin
  • Fever mentioned in 16.0% of FDA reports for Palifermin
  • Numbness or tingling
  • Joint pain
  • A skin rash mentioned in 10.1% of FDA reports for Palifermin
  • Itching
  • Swelling

From the ADVERSE REACTIONS section of the FDA label for Palifermin. Read the label on DailyMed › Where a percentage is shown, it is the share of 388 voluntary FDA FAERS reports for Palifermin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Andiroba’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Andiroba side to compare — that is a limit of the record, not a statement that Andiroba has no side effects.

Overlapping uses

What Palifermin Is Prescribed For, and What Andiroba Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Palifermin is a prescription medicine with approved uses on its FDA label. Andiroba is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Palifermin is prescribed for: Kepivance (palifermin) is used to decrease how often and how long severe oral mucositis — painful sores in the mouth and throat — occurs in patients with hematologic malignancies (blood cancers such as lymphoma, leukemia, or multiple myeloma) who are receiving high-dose, cell-damaging (myelotoxic) therapy before an autologous hematopoietic stem cell transplant (a transplant using the patient's own stem cells). Kepivance is specifically indicated when the preparative chemotherapy or radiation regimen is expected to cause severe mucositis in most patients. It is not recommended for use with a high-dose melphalan conditioning regimen, and it was not found to be effective in the setting of allogeneic stem cell transplant (using a donor's cells). Its safety and effectiveness have not been established for patients with non-blood cancers (non-hematologic malignancies).

Andiroba has been studied for:

  • Oral mucositis studied, not established Andiroba has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Andiroba for oral mucositis

    It is unclear if topical andiroba oil is beneficial in children with methotrexate-induced oral mucositis.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Palifermin on your own; if you are taking Andiroba for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Palifermin

This page covers Andiroba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Palifermin page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Palifermin page

“Palifermin (Kepivance) is given by IV to prevent the severe mouth sores that intensive chemotherapy can cause, most often in patients heading into a stem cell transplant, and I read its interaction list with genuine caution because of how fragile those patients already are. All 17 supplements on file act on absorption through the gut,…”

Reviewed by 2 · Jul 18, 2026

Open the Palifermin interaction page

How much people look this up

Where Andiroba and Palifermin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andiroba
Top half

#561 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Palifermin
Steady interest

#2,477 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Andiroba is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andiroba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Andiroba and Palifermin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Andiroba

What is Andiroba?

Andiroba
  • Skin care and wound healing
  • Insect repellent
  • Muscle and joint aches
  • Anti-inflammatory skin conditions
  • Hair and scalp care

Andiroba is an oil pressed from the seeds of an Amazonian tree, used mainly on the skin for inflammation, minor wounds, aches, and as an insect repellent. Most evidence comes from laboratory and animal studies, so its benefits in people are not well proven. It is most often used topically; avoid internal use and use during pregnancy or breastfeeding because safety has not been established.

Carapa guianensis · Meliaceae · Seed oil (mainly), bark, and leaves · Topical oil, skin and hair products, soaps, balms, candles (insect repellent)

An interaction check asks whether these two react with each other — it does not ask whether Andiroba is a good idea for someone in your situation. Here is what our Andiroba record says about it on its own.

Andiroba: dosing

There is no established standard dose for andiroba. Doses have not been confirmed in reliable human studies.For topical products, follow the directions on the label.

From our Andiroba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Andiroba monograph & all interactions
Medication

About Palifermin

What Is Palifermin Used For?

Brand name: Kepivance

Kepivance (palifermin) is used to decrease how often and how long severe oral mucositis — painful sores in the mouth and throat — occurs in patients with hematologic malignancies (blood cancers such as lymphoma, leukemia, or multiple myeloma) who are receiving high-dose, cell-damaging (myelotoxic) therapy before an autologous hematopoietic stem cell transplant (a transplant using the patient's own stem cells).

Kepivance is specifically indicated when the preparative chemotherapy or radiation regimen is expected to cause severe mucositis in most patients. It is not recommended for use with a high-dose melphalan conditioning regimen, and it was not found to be effective in the setting of allogeneic stem cell transplant (using a donor's cells). Its safety and effectiveness have not been established for patients with non-blood cancers (non-hematologic malignancies).

Most-Reported Side Effects for Palifermin

From FAERS, the FDA’s public side-effect reporting system (388 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Mucosal inflammation 56 reports
Febrile neutropenia 39 reports
Rash 39 reports
Stomatitis 34 reports
Erythema 28 reports
See full Palifermin drug information
Keep checking

Other Drugs & Andiroba

Browse every other medication we’ve checked against Andiroba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
50Minor
2,779No known interaction
50 Minor 2,779 No interaction
Minor

50 interactions

No interaction 2,779 drugs checked — show the list

We also checked Andiroba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,779 medications checked with no known interaction — see the full Andiroba list.

See the full Andiroba interactions page
See every supplement checked against Palifermin, ranked by severity
Evidence & sources

Andiroba References

The 3 sources that drive our Andiroba monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Andiroba is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Carapa guianensis (Andiroba) — U.S. National Library of Medicine (PubChem / NCBI) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  3. Using Dietary Supplements Safely — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Andiroba and Palifermin Together: Common Questions

Is it safe to take Andiroba with Palifermin?
We do not list a known interaction between Andiroba and Palifermin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Andiroba and Palifermin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Andiroba in each. That is a conversation for your prescriber, especially if Palifermin is being adjusted to a target.
How was the Andiroba and Palifermin combination checked?
Interactions in our licensed database are recorded against drug classes. Palifermin is filed under 1 classification, and Andiroba has documented interactions with 1 drug class — none of Palifermin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Andiroba interact with any other medications?
Yes. Andiroba has 50 documented drug interactions in our database — Palifermin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Palifermin interact with any supplements?
Yes. Palifermin has documented interactions with 17 supplements in our database — Andiroba is not one of them. The Palifermin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Andiroba monograph Uses, safety profile, and every drug interaction in one place Palifermin drug information The full plain-English guide to this medication Palifermin supplement interactions Every supplement checked against Palifermin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Palifermin and Andiroba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.