Drug & supplement interaction

Cannabidiol (cbd) + Deferiprone

Deferiprone brand name: Ferriprox.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Cannabidiol (cbd) and Deferiprone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Deferiprone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cannabidiol (cbd) and Deferiprone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Deferiprone and Cannabidiol (cbd) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cannabidiol (cbd) safety at a glance

Cannabidiol (cbd) overall Use caution CBD is generally well tolerated but can cause side effects and quality varies between products.

Pregnancy Possibly Unsafe When used orally. The US Food and Drug Administration (FDA) strongly advises against the use of cannabidiol during pregnancy. Cannabidiol products might contain... Read the full pregnancy detail

Breastfeeding Possibly Unsafe When used orally. The US Food and Drug Administration (FDA) strongly advises against the use of cannabidiol during pregnancy. Cannabidiol products might contain... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Deferiprone and Cannabidiol (cbd)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Deferiprone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Deferiprone is filed under a single classification — oral drugs. Cannabidiol (cbd) has documented interactions with 37 drug classes — the most serious being brivaracetam (briviact) (moderate), caffeine (moderate) and carbamazepine (tegretol) (moderate) — and none of Deferiprone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cannabidiol (cbd) Does Interact With Other Medications

Cannabidiol (cbd) has 1,051 moderate known drug interactions in our database — Deferiprone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1,051 No known interaction 1,779 (incl. Deferiprone)

Taking anything else?

Check Another of Your Medications Against Cannabidiol (cbd)

Covers the 2,830 medications we’ve checked against Cannabidiol (cbd). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cannabidiol (cbd) and Deferiprone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

Liver problems Worth acting on Additional detail
Cannabidiol (cbd)
“Orally, cannabidiol oil has been associated with an elevation in liver transaminases and drug-induced liver injury (DILI). A meta-analysis of 12 clinical trials shows that taking cannabidiol daily is associated with approximately 5 times greater odds of DILI and 6 times greater odds of liver enzyme elevations when compared with placebo.”

Cannabidiol (cbd) · Natural Medicines adverse-effect record, reported in myasthenia gravis.
6 sources cited

113045. Lo LA, Christiansen A, Eadie L, et al. Cannabidiol-associated hepatotoxicity: A systematic review and meta-analysis. J Intern Med 2023;293(6):724-752. PubMed

110244. Souza JDR, Pacheco JC, Rossi GN, et al. Adverse Effects of Oral Cannabidiol: An Updated Systematic Review of Randomized Controlled Trials (2020-2022). Pharmaceutics 2022;14(12):2598. PubMed

109176. Atieh J, Maselli D, Breen-Lyles M, et al. Cannabidiol for functional dyspepsia with normal gastric emptying: A randomized controlled trial. Am J Gastroenterol 2022;117(8):1296-1304. PubMed

113034. Georgieva D, Langley J, Hartkopf K, et al. Real-world, long-term evaluation of the tolerability and therapy retention of Epidiolex® (cannabidiol) in patients with refractory epilepsy. Epilepsy Behav 2023;141:109159. PubMed

107324. Davis BH, Beasley TM, Amaral M, et al. Pharmacogenetic Predictors of Cannabidiol Response and Tolerability in Treatment-Resistant Epilepsy. Clin Pharmacol Ther 2021;110(5):1368-1380. PubMed

107336. Kaufmann R, Aqua K, Lombardo J, Lee M. Observed Impact of Long-term Consumption of Oral Cannabidiol on Liver Function in Healthy Adults. Cannabis Cannabinoid Res 2021. PubMed
Deferiprone

Listed in the ADVERSE REACTIONS section of the FDA label for Deferiprone. Read the label on DailyMed ›
Weight gain / Stomach pain / Nausea reported in 5.3% of FDA reports for Deferiprone Additional detail
Cannabidiol (cbd)
“Orally, cannabidiol has caused dry mouth in some patients in clinical research. In children and adults, cannabidiol oil has caused mild to moderate diarrhea, decreased appetite, weight loss, nausea, and vomiting. Diarrhea, decreased appetite, and weight loss or weight gain have been reported at a higher frequency with doses greater than 15-20 mg/kg daily.”

Cannabidiol (cbd) · Natural Medicines adverse-effect record, reported in constipation.
6 sources cited

89700. Consroe P, Sandyk R, Snider SR. Open label evaluation of cannabidiol in dystonic movement disorders. Int J Neurosci 1986;30(4):277-82. PubMed

105559. Velayudhan L, McGoohan K, Bhattacharyya S. Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta-analysis. PLoS Med. 2021;18(3):e1003524. PubMed

109177. Berger M, Li E, Rice S, et al. Cannabidiol for treatment-resistant anxiety disorders in young people: An open-label trial. J Clin Psychiatry 2022;83(5):21m14130. PubMed

110245. Dahlgren MK, Lambros AM, Smith RT, Sagar KA, El-Abboud C, Gruber SA. Clinical and cognitive improvement following full-spectrum, high-cannabidiol treatment for anxiety: open-label data from a two-stage, phase 2 clinical trial. Commun Med (Lond) 2022;2(1): PubMed

110249. Zubcevic K, Petersen M, Bach FW, et al. Oral capsules of tetra-hydro-cannabinol (THC), cannabidiol (CBD) and their combination in peripheral neuropathic pain treatment. Eur J Pain 2022.

97017. Devinsky O, Cross JH, Laux L, et al. Trial of cannabidiol for drug-resistant seizures in the Dravet Syndrome. N Engl J Med. 2017 May 25;376(21):2011-2020. PubMed
Deferiprone

Listed in the ADVERSE REACTIONS section of the FDA label for Deferiprone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Sore throat Additional detail
Cannabidiol (cbd)
“Orally, cannabidiol oil has been associated with rare respiratory depression and increased odds of pneumonia. In a case report, a 56-year-old obese male presented to the emergency room with severe respiratory depression 3 hours after consuming two packages of gummies labeled to contain cannabidiol 370 mg. Symptoms included respiratory acidosis, slurred speech, bradycardia, and vomiting.”

Cannabidiol (cbd) · Natural Medicines adverse-effect record, reported in cancer.
6 sources cited

103029. Bass J, Linz DR. A Case of Toxicity from Cannabidiol Gummy Ingestion. Cureus. 2020;12(4):e7688. PubMed

103031. Chesney E, Oliver D, Green A, et al. Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials. Neuropsychopharmacology. 2020. PubMed

106631. Patel AD, Mazurkiewicz-Beldzinska M, Chin RF, et al. Long-term safety and efficacy of add-on cannabidiol in patients with Lennox-Gastaut syndrome: Results of a long-term open-label extension trial. Epilepsia 2021;62(9):2228-2239. PubMed

106633. Scheffer IE, Halford JJ, Miller I, et al. Add-on cannabidiol in patients with Dravet syndrome: Results of a long-term open-label extension trial. Epilepsia 2021;62(10):2505-2517. PubMed

110247. Hardy J, Greer R, Huggett G, Kearney A, Gurgenci T, Good P. Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD). J Clin Oncol 2022. PubMed

61759. Rog, D. J., Nurmikko, T. J., Friede, T., and Young, C. A. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology 9-27-2005;65(6):812-819. PubMed
Deferiprone

Listed in the ADVERSE REACTIONS section of the FDA label for Deferiprone. Read the label on DailyMed ›
Reduced appetite / Diarrhea Additional detail

Cannabidiol (cbd)

Recorded for Cannabidiol (cbd) in the same Natural Medicines adverse-effect record shown under Liver problems above.

Deferiprone

Listed in the ADVERSE REACTIONS section of the FDA label for Deferiprone. Read the label on DailyMed ›
Fever Additional detail

Cannabidiol (cbd)

Recorded for Cannabidiol (cbd) in the same Natural Medicines adverse-effect record shown under Liver problems above.

Deferiprone

Listed in the ADVERSE REACTIONS section of the FDA label for Deferiprone. Read the label on DailyMed ›
Vomiting reported in 4.2% of FDA reports for Deferiprone Additional detail

Cannabidiol (cbd)

Recorded for Cannabidiol (cbd) in the same Natural Medicines adverse-effect record shown under Liver problems above.

Deferiprone

Listed in the ADVERSE REACTIONS section of the FDA label for Deferiprone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Cannabidiol (cbd) but not commonly for Deferiprone: low blood pressure, dependence or withdrawal symptoms, memory problems and unsteadiness.

Effects for Deferiprone come from the ADVERSE REACTIONS section of its FDA label; effects for Cannabidiol (cbd) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,004 voluntary FDA FAERS reports for Deferiprone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Cannabidiol (cbd) in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. The US Food and Drug Administration (FDA) strongly advises against the use of cannabidiol during pregnancy. Cannabidiol products might contain delta-9-tetrahydrocannabinol (THC) or other contaminants such as pesticides, heavy metals, bacteria, and fungus, which can be dangerous to the child. Also, animal research shows that high levels of cannabidiol can damage the reproductive system of male offspring.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Deferiprone Products Have a Food Rule — Cannabidiol (cbd) Should Not Break It

At least one FDA label for a product containing Deferiprone says to take it with food. If you take Cannabidiol (cbd) on an empty stomach out of habit, keep them separate — and take Deferiprone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Deferiprone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Recommended Dosage for 1,000 mg FERRIPROX T ablets ( twice a day) for Adult and Pediatric Patients with Transfusional Iron Overload due to Thalassemia Syndromes, Sickle Cell Disease or Other Anemias Starting Dos ag e for T wice a Day Tablets The recommended starting oral dosage of FERRIPROX Tablets (twice a day) is 75 mg/kg/day (actual body weight) in two divided doses per day (taken approxima

From the Dosage and Administration section of the FDA label we read for Deferiprone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Deferiprone

This page covers Cannabidiol (cbd) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Deferiprone page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Deferiprone page

“Deferiprone (Ferriprox) pulls excess iron out of the body in conditions like thalassemia, and that job depends on the pill actually being absorbed. Every one of the 17 supplements flagged against it threatens that step, which is why this list warrants real vigilance rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Deferiprone interaction page

How much people look this up

Where Cannabidiol (cbd) and Deferiprone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabidiol (cbd)

Top half

#554 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Deferiprone

Top half

#903 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabidiol (cbd) reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cannabidiol (cbd) and Deferiprone records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Cannabidiol (cbd)

What is Cannabidiol (cbd)?

Anxiety and stress
Sleep problems
Chronic pain
Certain seizure disorders
Inflammation

CBD is a compound from the cannabis (hemp) plant that does not cause a 'high.' It has strong evidence only for certain rare seizure disorders (as a prescription drug), while most other popular uses are still backed by limited or early research. Product quality varies a lot, so talk with your pharmacist or doctor before using it, especially if you take other medicines.

Cannabis sativa · Cannabaceae · Flowers, leaves, and stalks of the hemp plant (extracted compound) · Oils and tinctures, capsules, gummies, topical creams, vape liquids, and a prescription solution

An interaction check asks whether these two react with each other — it does not ask whether Cannabidiol (cbd) is a good idea for someone in your situation. Here is what our Cannabidiol (cbd) record says about it on its own.

Cannabidiol (cbd): dosing

There is no single standard dose of CBD for general supplement use. The right amount can depend on the product, the reason for use, and the person. Because of this, it is best to follow the directions on the product label and start with a low amount.The only well-established dosing comes from the prescription CBD medicine used for seizures, which is carefully dosed by a doctor based on body weight. They can help you decide whether it is appropriate for you and review your other medicines for possible problems.

From our Cannabidiol (cbd) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cannabidiol (cbd) monograph & all interactions

Medication

About Deferiprone

What Is Deferiprone Used For?

Brand name: Ferriprox

Deferiprone is used to remove excess iron that builds up in the body from repeated blood transfusions — a condition called transfusional iron overload. Too much iron in the body can damage organs over time, so deferiprone works to capture and remove it.

Ferriprox oral solution is approved for adults and children 3 years and older with thalassemia syndromes, sickle cell disease, or other anemias. Ferriprox tablets are approved for adults and children 8 years and older with the same conditions. Deferiprone tablets (generic) are approved for adult patients with thalassemia syndromes when their current iron-removal treatment is not working well enough.

Most-Reported Side Effects for Deferiprone

From FAERS, the FDA’s public side-effect reporting system (3,004 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Sickle cell anaemia with crisis 191 reports

Agranulocytosis 158 reports

Nausea 158 reports

Fatigue 138 reports

Ill-defined disorder 135 reports

See full Deferiprone drug information

Keep checking

Other Drugs & Cannabidiol (cbd)

Browse every other medication we’ve checked against Cannabidiol (cbd) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

1,051Moderate

0Minor

1,778No known interaction

1,051 Moderate 1,778 No interaction

Moderate

1,051 interactions

Showing 60 of 1,051 moderate interactions — see all 1,051 on the Cannabidiol (cbd) page.

No interaction 1,778 drugs checked — show the list

We also checked Cannabidiol (cbd) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,778 medications checked with no known interaction — see the full Cannabidiol (cbd) list.

See the full Cannabidiol (cbd) interactions page

See every supplement checked against Deferiprone, ranked by severity

Evidence & sources

Cannabidiol (cbd) References

The 93 references that drive our Cannabidiol (cbd) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Rog, D. J., Nurmikko, T. J., Friede, T., and Young, C. A. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology 9-27-2005;65(6):812-819. PubMed
Perras, C. Sativex for the management of multiple sclerosis symptoms. Issues Emerg.Health Technol. 2005;(72):1-4.
Rog, D. J., Nurmikko, T. J., and Young, C. A. Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial. Clin Ther. 2007;29(9):2068-2079.
Consroe, P., Laguna, J., Allender, J., Snider, S., Stern, L., Sandyk, R., Kennedy, K., and Schram, K. Controlled clinical trial of cannabidiol in Huntington's disease. Pharmacol Biochem.Behav. 1991;40(3):701-708. PubMed
Lynch, M. E. and Campbell, F. Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. Br.J.Clin.Pharmacol. 2011;72(5):735-744. PubMed
Richards, B. L., Whittle, S. L., and Buchbinder, R. Neuromodulators for pain management in rheumatoid arthritis. Cochrane.Database.Syst.Rev. 2012;1:CD008921. PubMed
Carlini EA, Cunha JM. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol 1981;21(8-9 Suppl):417S-27S. PubMed
Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology 2011;36(6):1219-26. PubMed
Yamaori S, Kushihara M, Yamamoto I, Watanabe K. Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective potent inhibitors of human CYP1 enzymes. Biochem Pharmacol 2010;79(11):1691-8.
Yamaori S, Maeda C, Yamamoto I, Watanabe K. Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids. Forensic Toxicol 2011;29:117-24. DOI
Yamaori S, Okamoto Y, Yamamoto I, Watanabe K. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos 2011;39(11):2049-56. PubMed
Yamaori S, Ebisawa J, Okushima Y, et al. Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. Life Sci 2011;88(15-16):730-6. PubMed
Harvey DJ. Absorption, distribution, and biotransformation of the cannabinoids. Marijuana and Medicine. 1999;91-103. DOI
Bornheim LM, Everhart ET, Li J, Correia MA. Characterization of cannabidiol-mediated cytochrome P450 inactivation. Biochem Pharmacol 1993;45(6):1323-31. PubMed
Consroe P, Sandyk R, Snider SR. Open label evaluation of cannabidiol in dystonic movement disorders. Int J Neurosci 1986;30(4):277-82. PubMed
Zuardi AW, Cosme RA, Graeff FG, Guimaraes FS. Effects of ipsapirone and cannabidiol on human experimental anxiety. J Psychopharmacol 1993;7(1 Suppl):82-8. PubMed
Monti JM. Hypnoticlike effects of cannabidiol in the rat. Psychopharmacology (Berl) 1977;55(3):263-5. PubMed
Pickens JT. Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content. Br J Pharmacol 1981;72(4):649-56.
Duran M, Pérez E, Abanades S, et al. Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. Br J Clin Pharmacol. 2010;70(5):656-63. PubMed
Devinsky O, Cross JH, Laux L, et al. Trial of cannabidiol for drug-resistant seizures in the Dravet Syndrome. N Engl J Med. 2017 May 25;376(21):2011-2020. PubMed
Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP; UAB CBD Program. Interactions between cannabidiol and commonly used antiepileptic drugs. Epilepsia. 2017 Sep;58(9):1586-92. PubMed
Hess EJ, Moody KA, Geffrey AL, et al. Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex. Epilepsia. 2016 Oct;57(10):1617-24. PubMed
97021 Jadoon KA, Ratcliffe SH, Barrett DA, et al. Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel group pilot study. PubMed
Devinsky O, Marsh E, Friedman D, et la. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol. 2016 Mar;15(3):270-8.
Geffrey AL, Pollack SF, Bruno PL, Thiele EA. Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy. Epilepsia. 2015 Aug;56(8):1246-51. PubMed
Kaplan EH, Offermann EA, Sievers JW, Comi AM. Cannabidiol treatment for refractory seizures in Sturge-Weber Syndrome. Pediatr Neurol. 2017 Jun;71:18-23.e2. PubMed
Devinsky O, Patel AD, Cross JH, et al. Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome. N Engl J Med. 2018 May 17;378(20):1888-1897. PubMed
Thiele EA, Marsh ED, French JA, et al. Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2018 Mar 17;391(10125):1085-1096.
Schoedel KA, Szeto I, Setnik B, et al. Abuse potential assessment of cannabidiol (CBD) in recreational polydrug users: A randomized, double-blind, controlled trial. Epilepsy Behav. 2018 Nov;88:162-171. doi: 10.1016/j.yebeh.2018.07.027. Epub 2018 Oct 2. PubMed
Drug Enforcement Administration, Department of Justice. Schedules of Controlled Substances: Placement in Schedule V of Certain FDA-Approved Drugs Containing Cannabidiol; Corresponding Change to Permit Requirements. Final order. Fed Regist. 2018 Sep 28;83(
Epidiolex (cannabidiol) prescribing information. Greenwich Biosciences, Inc., Carlsbad, CA, 2019. Available at: https://www.epidiolex.com/sites/default/files/EPIDIOLEX_Full_Prescribing_Information.pdf (accessed 5/9/2019)
Product information for Marinol. AbbVie. North Chicago, IL 60064. August 2017. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018651s029lbl.pdf.
Klotz KA, Hirsch M, Heers M, Schulze-Bonhage A, Jacobs J. Effects of cannabidiol on brivaracetam plasma levels. Epilepsia. 2019;60(7):e74-e77. PubMed
Laux LC, Bebin EM, Checketts D, et al. Long-term safety and efficacy of cannabidiol in children and adults with treatment resistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results. Epilepsy Res. 2019;154:13-20. PubMed
Leino AD, Emoto C, Fukuda T, Privitera M, Vinks AA, Alloway RR. Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus. Am J Transplant. 2019;19(10):2944-2948. PubMed
Martin RC, Gaston TE, Thompson M, et al. Cognitive functioning following long-term cannabidiol use in adults with treatment-resistant epilepsy. Epilepsy Behav. 2019;97:105-110. PubMed
FDA Consumer Updates: What You Should Know About Using Cannabis, Including CBD, When Pregnant or Breastfeeding. U. S. Food and Drug Administration (FDA). October 2019. Available at: https://www.fda.gov/consumers/consumer-updates/what-you-should-know-about
Wiemer-Kruel A, Stiller B, Bast T. Cannabidiol Interacts Significantly with Everolimus-Report of a Patient with Tuberous Sclerosis Complex. Neuropediatrics. 2019. PubMed
Klotz KA, Grob D, Hirsch M, Metternich B, Schulze-Bonhage A, Jacobs J. Efficacy and Tolerance of Synthetic Cannabidiol for Treatment of Drug Resistant Epilepsy. Front Neurol. 2019 Dec 10;10:1313. PubMed
Madden K, Tanco K, Bruera E. Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol. Pediatrics. 2020;e20193256. PubMed
Bass J, Linz DR. A Case of Toxicity from Cannabidiol Gummy Ingestion. Cureus. 2020;12(4):e7688. PubMed
Ben-Menachem E, Gunning B, Arenas Cabrera CM, et al. A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy. CNS Drugs. 2020;34 PubMed
Chesney E, Oliver D, Green A, et al. Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials. Neuropsychopharmacology. 2020. PubMed
Darweesh RS, Khamis TN, El-Elimat T. The effect of cannabidiol on the pharmacokinetics of carbamazepine in rats. Naunyn Schmiedebergs Arch Pharmacol. 2020. PubMed
de Carvalho Reis R, Almeida KJ, da Silva Lopes L, de Melo Mendes CM, Bor-Seng-Shu E. Efficacy and adverse event profile of cannabidiol and medicinal cannabis for treatment-resistant epilepsy: Systematic review and meta-analysis. Epilepsy Behav. 2020;102:1 PubMed
Ebrahimi-Fakhari D, Agricola KD, Tudor C, Krueger D, Franz DN. Cannabidiol Elevates Mechanistic Target of Rapamycin Inhibitor Levels in Patients With Tuberous Sclerosis Complex. Pediatr Neurol. 2020;105:59-61. PubMed
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cannabidiol (cbd) and Deferiprone Together: Common Questions

Is it safe to take Cannabidiol (cbd) with Deferiprone?

We do not list a known interaction between Cannabidiol (cbd) and Deferiprone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Cannabidiol (cbd) and Deferiprone have any of the same side effects?

Yes — our sources link each of them separately to 9 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Should I take Cannabidiol (cbd) and Deferiprone at the same time of day?

At least one FDA label for a product containing Deferiprone says to take it with food. If you take Cannabidiol (cbd) on an empty stomach out of habit, keep them separate and take Deferiprone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Deferiprone products can differ — so check the directions on your own box. This is about absorption, not an interaction.

How was the Cannabidiol (cbd) and Deferiprone combination checked?

Interactions in our licensed database are recorded against drug classes. Deferiprone is filed under 1 classification, and Cannabidiol (cbd) has documented interactions with 37 drug classes — none of Deferiprone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Cannabidiol (cbd) interact with any other medications?

Yes. Cannabidiol (cbd) has 1,051 documented drug interactions in our database — Deferiprone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Deferiprone interact with any supplements?

Yes. Deferiprone has documented interactions with 17 supplements in our database — Cannabidiol (cbd) is not one of them. The Deferiprone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Cannabidiol (cbd) monograph Uses, safety profile, and every drug interaction in one place Deferiprone drug information The full plain-English guide to this medication Deferiprone supplement interactions Every supplement checked against Deferiprone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 93 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.