Drug & supplement interaction

Equol + Vericiguat

Vericiguat brand name: Verquvo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Equol and Vericiguat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Vericiguat states a food rule worth keeping to.

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Interaction report

Equol and Vericiguat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Vericiguat and Equol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Equol safety at a glance

Equol overall Use caution Generally well tolerated in studies, but long-term safety and effects on hormone-sensitive conditions are not well established.
Pregnancy Avoid Not enough safety data and possible hormone-like effects, so it is best avoided.
Breastfeeding Avoid There is no reliable safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Vericiguat and Equol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Vericiguat

Interactions in our licensed database are recorded against drug classes, not just single drug names. Vericiguat is filed under 2 classifications — p-glycoprotein substrates, oral drugs. Equol has documented interactions with 4 drug classes — the most serious being contraceptive drugs (moderate), estrogens (moderate) and testosterone (moderate) — and none of Vericiguat’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Equol Does Interact With Other Medications

Equol has 58 moderate, 75 minor known drug interactions in our database — Vericiguat isn’t one of them. If you take anything else, check it against the full list below.

Moderate 58 Minor 75 No known interaction 2,697 (incl. Vericiguat)
Taking anything else?

Check Another of Your Medications Against Equol

Covers the 2,830 medications we’ve checked against Equol. Pick one to open its full report.

What to actually watch for

What Equol Itself Has Been Linked To

This is not an interaction — nothing below involves Vericiguat. It is the side-effect record for Equol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Equol, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on Additional detail

    “Orally, equol has been rarely reported to cause depression.”

    Equol · Natural Medicines adverse-effect record, reported in depression.

    1 source cited
    1. 19075. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt) 2012;21:674-82.
  • Bloating or gas Additional detail

    Recorded for Equol in the same Natural Medicines adverse-effect record shown under Low mood above.

  • Constipation Additional detail

    “Orally, equol has been reported to cause abdominal distention and constipation.”

    Equol · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 19075. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt) 2012;21:674-82.

Everything above comes from the Natural Medicines adverse-effect record for Equol — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Vericiguat’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Vericiguat column appears here.

How to take them

Some Vericiguat Products Have a Food Rule — Equol Should Not Break It

At least one FDA label for a product containing Vericiguat says to take it with food. If you take Equol on an empty stomach out of habit, keep them separate — and take Vericiguat with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Vericiguat products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The recommended starting dose of VERQUVO is 5 mg orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Vericiguat — where that label names a specific product, the instruction is that product's. See the Vericiguat drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Vericiguat

This page covers Equol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Vericiguat page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Vericiguat page

“No supplement on this page worries me more for vericiguat (Verquvo) users than St. John's wort.”

Reviewed by 2 · Jul 18, 2026

Open the Vericiguat interaction page

How much people look this up

Where Equol and Vericiguat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Equol
Steady interest

#853 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Vericiguat
Steady interest

#2,656 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Equol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Equol and Vericiguat records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Equol

What is Equol?

  • Menopause symptoms (hot flashes)
  • Bone health support
  • Skin aging
  • Prostate health
  • General hormone balance

Equol is a compound made in the gut when some people break down soy isoflavones, and it is also sold as a supplement. Early research links it to possible benefits for menopause symptoms and bone or skin health, but the evidence is still limited and far from proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Not a plant part; a metabolite produced by gut bacteria from soy isoflavones (daidzein) · Capsules, tablets, and as a component of fermented soy or red clover supplements

An interaction check asks whether these two react with each other — it does not ask whether Equol is a good idea for someone in your situation. Here is what our Equol record says about it on its own.

Equol: dosing

There is no official or standardized dose of equol. Amounts used in research have varied, and supplement products differ in how much they contain.The best approach is to follow the directions on the product label and not take more than recommended.

From our Equol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Equol monograph & all interactions
Medication

About Vericiguat

What Is Vericiguat Used For?

Brand name: Verquvo

Verquvo (vericiguat) is used to reduce the risk of cardiovascular death and hospitalization due to heart failure. It is specifically for adults with symptomatic chronic heart failure whose heart pumps with reduced function (ejection fraction less than 45%), following a recent hospitalization for heart failure or a need for IV diuretics given outside the hospital.

Verquvo is taken on top of other standard heart failure treatments — it is not a replacement for them.

Most-Reported Side Effects for Vericiguat

From FAERS, the FDA’s public side-effect reporting system (966 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hypotension 111 reports
Cardiac failure 72 reports
Dizziness 68 reports
Anemia 40 reports
Blood pressure decreased 40 reports
See full Vericiguat drug information
Keep checking

Other Drugs & Equol

Browse every other medication we’ve checked against Equol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
58Moderate
75Minor
2,696No known interaction
58 Moderate 75 Minor 2,696 No interaction
Moderate

58 interactions

Minor

75 interactions

Showing 60 of 75 minor interactions — see all 75 on the Equol page.

No interaction 2,696 drugs checked — show the list

We also checked Equol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,696 medications checked with no known interaction — see the full Equol list.

See the full Equol interactions page
See every supplement checked against Vericiguat, ranked by severity
Evidence & sources

Equol References

The 7 references that drive our Equol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Aso T. Equol improves menopausal symptoms in Japanese women. J Nutr 2010;140:1386S-9S. PubMed
  2. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt) 2012;21:674-82.
  3. Oyama A, Ueno T, Uchiyama S, et al. The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial. Menopause 2012;19:202-10. PubMed
  4. Gimenez I, Lou M, Vargas F, et al. Renal and vascular actions of equol in the rat. J Hypertens 1997;15:1303-8. PubMed
  5. Martin ME, Haouriqui M, Pelissero C, et al. Interactions between phytoestrogens and human sex steroid binding protein. Life Sci 1996;58:429-36. PubMed
  6. Martinez RM, Gimenez I, Lou JM, et al. Soy isoflavonoids exhibit in vitro biological activities of loop diuretics. Am J Clin Nutr 1998;68:1354S-57S. PubMed
  7. Alda JO, Mayoral JA, Lou M, et al. Purification and chemical characterization of a potent inhibitor of the Na-K-Cl cotransport system in rat urine. Biochem Biophys Res Commun 1996;221:279-85. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Equol and Vericiguat Together: Common Questions

Is it safe to take Equol with Vericiguat?
We do not list a known interaction between Equol and Vericiguat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Equol and Vericiguat at the same time of day?
At least one FDA label for a product containing Vericiguat says to take it with food. If you take Equol on an empty stomach out of habit, keep them separate and take Vericiguat with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Vericiguat products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Equol and Vericiguat combination checked?
Interactions in our licensed database are recorded against drug classes. Vericiguat is filed under 2 classifications, and Equol has documented interactions with 4 drug classes — none of Vericiguat's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Equol interact with any other medications?
Yes. Equol has 133 documented drug interactions in our database — Vericiguat is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Vericiguat interact with any supplements?
Yes. Vericiguat has documented interactions with 54 supplements in our database — Equol is not one of them. The Vericiguat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Equol monograph Uses, safety profile, and every drug interaction in one place Vericiguat drug information The full plain-English guide to this medication Vericiguat supplement interactions Every supplement checked against Vericiguat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Vericiguat and Equol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.