Drug & supplement interaction

Galphimia Glauca + Doxycycline Hyclate

Doxycycline Hyclate brand names: Acticlate, Acticlate Cap, Lymepak.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Galphimia Glauca and Doxycycline Hyclate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Doxycycline Hyclate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Galphimia Glauca and Doxycycline Hyclate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doxycycline Hyclate and Galphimia Glauca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Galphimia Glauca safety at a glance

Galphimia Glauca overall Use caution Short-term studies suggest it is generally well tolerated, but long-term safety data are limited.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doxycycline Hyclate and Galphimia Glauca? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Doxycycline Hyclate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Doxycycline Hyclate is filed under 9 classifications — including tetracycline antibiotics, antibiotic drugs, p-glycoprotein substrates. Galphimia Glauca has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Doxycycline Hyclate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Galphimia Glauca Does Interact With Other Medications

Galphimia Glauca has 248 moderate known drug interactions in our database — Doxycycline Hyclate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Doxycycline Hyclate)
Taking anything else?

Check Another of Your Medications Against Galphimia Glauca

Covers the 2,830 medications we’ve checked against Galphimia Glauca. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Galphimia Glauca and Doxycycline Hyclate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Anxiety or restlessness Additional detail

    Galphimia Glauca

    “Orally, Galphimia glauca extract 7-14 mg daily has been associated with sedation and headache. Rarely, restlessness, nervousness, weakness, and other side effects have been reported; but it is unclear if Galphimia glauca was the causal factor.”

    Galphimia Glauca · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 99507. Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed

    Doxycycline Hyclate

    Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline Hyclate. Read the label on DailyMed ›

  • Headache Additional detail

    Galphimia Glauca

    “Orally, Galphimia glauca seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Epigastric burning, headache, nausea, sedation.”

    Galphimia Glauca · Natural Medicines adverse-effect record, reported in cluster headache.

    Doxycycline Hyclate

    Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline Hyclate. Read the label on DailyMed ›

  • Nausea Additional detail

    Galphimia Glauca

    “Orally, Galphimia glauca extract 7-14 mg daily has been associated with nausea and epigastric burning.”

    Galphimia Glauca · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 99507. Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed

    Doxycycline Hyclate

    Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline Hyclate. Read the label on DailyMed ›

Reported for Galphimia Glauca but not commonly for Doxycycline Hyclate: drowsiness.

Effects for Doxycycline Hyclate come from the ADVERSE REACTIONS section of its FDA label; effects for Galphimia Glauca come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Doxycycline Hyclate Products Have a Food Rule — Galphimia Glauca Should Not Break It

At least one FDA label for a product containing Doxycycline Hyclate says to take it on an empty stomach. Most supplements — Galphimia Glauca included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Doxycycline Hyclate on its own and move Galphimia Glauca to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Doxycycline Hyclate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Take one Doxycycline capsule (40 mg) once daily in the morning on an empty stomach, preferably at least one hour prior to or two hours after meals.

From the Dosage and Administration section of the FDA label we read for Doxycycline Hyclate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Galphimia Glauca or Doxycycline Hyclate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Galphimia Glauca or Doxycycline Hyclate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Doxycycline Hyclate

This page covers Galphimia Glauca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxycycline Hyclate page lists 166 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Oleander (major) and Siberian Cocklebur (major).

Open the Doxycycline Hyclate interaction page

How much people look this up

Where Galphimia Glauca and Doxycycline Hyclate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Galphimia Glauca
Steady interest

#1,171 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doxycycline Hyclate
Top half

#1,013 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Galphimia Glauca reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Galphimia Glauca and Doxycycline Hyclate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Galphimia Glauca

What is Galphimia Glauca?

Galphimia Glauca
  • Anxiety and stress
  • Insomnia
  • Allergic rhinitis and hay fever
  • Respiratory complaints
  • Traditionally used as an anticonvulsant

Galphimia glauca is a shrub from Mexico and Central America that has been studied mainly for anxiety, with some small clinical trials suggesting possible benefit. Overall the evidence is still limited and its long-term safety is not well established, so talk with your pharmacist or doctor before using it.

Galphimia glauca · Malpighiaceae · Leaves and aerial parts · Capsules, standardized extracts, tinctures, homeopathic preparations, tea

An interaction check asks whether these two react with each other — it does not ask whether Galphimia Glauca is a good idea for someone in your situation. Here is what our Galphimia Glauca record says about it on its own.

Galphimia Glauca: dosing

There is no well-established standard dose of Galphimia glauca. Clinical studies have used standardized extracts, but products on the market vary widely in their strength and how they are made.Because of this, follow the directions on the product label and do not exceed the recommended amount.

From our Galphimia Glauca monograph — the full record covers uses, side effects and every documented interaction.

Read the full Galphimia Glauca monograph & all interactions
Medication

About Doxycycline

What Is Doxycycline Used For?

Brand names: Acticlate, Acticlate Cap, Lymepak

Doxycycline is an antibiotic. It treats infections caused by bacteria, and it does not work on viruses.

Several products carry a broad list of uses, including rickettsial infections, sexually transmitted infections, respiratory tract infections, eye infections, and anthrax after exposure. Some product labels also list malaria prevention, and use as an add-on treatment for acute intestinal amebiasis and severe acne. Doxycycline for Injection (Doxy 100, intravenous) is approved for infections caused by a listed set of microorganisms. Doxycycline capsules in the Oracea-type low-dose form are described in the evidence for inflammatory lesions of rosacea.

See full Doxycycline drug information
Keep checking

Other Drugs & Galphimia Glauca

Browse every other medication we’ve checked against Galphimia Glauca — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Galphimia Glauca page.

No interaction 2,581 drugs checked — show the list

We also checked Galphimia Glauca against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Galphimia Glauca list.

See the full Galphimia Glauca interactions page
See every supplement checked against Doxycycline Hyclate, ranked by severity
Evidence & sources

Galphimia Glauca References

The 2 references that drive our Galphimia Glauca monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Herrera-Arellano, A., Jimenez-Ferrer, E., Zamilpa, A., et al. Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical trial controlled with lorazepam. Planta Med
  2. Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Galphimia Glauca and Doxycycline Hyclate Together: Common Questions

Is it safe to take Galphimia Glauca with Doxycycline Hyclate?
We do not list a known interaction between Galphimia Glauca and Doxycycline Hyclate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Galphimia Glauca and Doxycycline Hyclate have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Galphimia Glauca and Doxycycline Hyclate at the same time of day?
At least one FDA label for a product containing Doxycycline Hyclate says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Doxycycline Hyclate on its own and move Galphimia Glauca to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Galphimia Glauca and Doxycycline Hyclate combination checked?
Interactions in our licensed database are recorded against drug classes. Doxycycline Hyclate is filed under 9 classifications, and Galphimia Glauca has documented interactions with 1 drug class — none of Doxycycline Hyclate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Galphimia Glauca interact with any other medications?
Yes. Galphimia Glauca has 248 documented drug interactions in our database — Doxycycline Hyclate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Doxycycline Hyclate interact with any supplements?
Yes. Doxycycline Hyclate has documented interactions with 166 supplements in our database — Galphimia Glauca is not one of them. The Doxycycline Hyclate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Galphimia Glauca monograph Uses, safety profile, and every drug interaction in one place Doxycycline drug information The full plain-English guide to this medication Doxycycline Hyclate supplement interactions Every supplement checked against Doxycycline Hyclate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doxycycline Hyclate and Galphimia Glauca?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.