Drug & supplement interaction

Inositol Nicotinate + Dalteparin

Dalteparin brand name: Fragmin.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Inositol Nicotinate has a moderate interaction with Dalteparin. Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Inositol Nicotinate and Dalteparin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Dalteparin

Dalteparin falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Inositol Nicotinate interacts with.

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Inositol nicotinate has fibrinolytic effects, which may increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Dalteparin (Fragmin) is an injectable blood thinner that lowers your blood's ability to clot. Here's the concern with inositol nicotinate: the niacin it releases is thought to have mild clot-busting (fibrinolytic) effects of its own. Stack that on top of dalteparin and, in theory, you could tip the balance toward more bleeding than intended.

I want to be honest that this is a theoretical interaction based on how these substances work, not on strong studies, so don't panic. Still, watch for signs like easy bruising, nosebleeds, bleeding gums, pink or red urine, or dark stools. Since you'd be combining a real anticoagulant with a supplement of questionable benefit, please check with your pharmacist or doctor before starting it rather than deciding on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  2. Holti G. An experimentally controlled evaluation of the effect of inositol nicotinate upon the digital blood flow in patients with Raynaud's phenomenon. J Int Med Res 1979;7:473-83. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Inositol Nicotinate Also Interacts With Other Medications

Inositol Nicotinate has 222 moderate known drug interactions in our database — the Dalteparin one above is one of them. If you take anything else, check it against the full list below.

Moderate 222 No known interaction 2,608 (incl. Dalteparin)
Taking anything else?

Check Another of Your Medications Against Inositol Nicotinate

Covers the 2,830 medications we’ve checked against Inositol Nicotinate. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dalteparin

This page covers Inositol Nicotinate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dalteparin page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 190 moderate · 25 minor.

From our pharmacist’s overview on the Dalteparin page

“Dalteparin (Fragmin) is an injectable blood thinner used to prevent and treat dangerous clots, which is exactly why this list warrants real vigilance, and nearly all 218 ingredients on it thin the blood too. They are herbs and extracts with clot-inhibiting or antiplatelet effects of their own, so stacking them on dalteparin can push bl…”

Reviewed by 2 · Jul 18, 2026

Open the Dalteparin interaction page

One more smart check

Taking Inositol Nicotinate as Part of a Dietary Supplement Product? Check It for Interactions

We hold 202 real supplement products containing Inositol Nicotinate, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Inositol Nicotinate. Your product may carry other ingredients that interact with Dalteparin too, on top of Inositol Nicotinate — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Inositol Nicotinate and Dalteparin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Inositol Nicotinate
Top 25%

#279 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dalteparin
Top half

#802 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Inositol Nicotinate

What is Inositol Nicotinate?

Inositol Nicotinate
  • Cholesterol support
  • Improving circulation
  • Raynaud's phenomenon
  • Intermittent claudication (leg pain with walking)
  • A 'no-flush' niacin alternative

Inositol nicotinate is a 'no-flush' form of niacin marketed for cholesterol and circulation. Evidence that it works as well as regular niacin is weak and inconsistent, and it is not a proven replacement for prescription cholesterol treatment. Talk to your pharmacist or doctor before using it, especially if you have liver problems or take other medicines.

Read the full Inositol Nicotinate monograph & all interactions
Medication

About Dalteparin Injection

What Is Dalteparin Injection Used For?

Brand name: Fragmin

Fragmin (dalteparin) injection is used to prevent blood clots (deep vein thrombosis, or DVT) in people having hip replacement or abdominal surgery, and in hospitalized patients who are largely immobile due to acute illness. It is also used to reduce ischemic complications — meaning clot-related events — in people with unstable angina or a type of heart attack called non-Q-wave MI, when given alongside aspirin.

Fragmin is approved for the extended treatment of symptomatic venous thromboembolism (VTE — blood clots in the veins or lungs) in adults with cancer, to reduce the chance of clots coming back, for up to six months. It is also approved to treat symptomatic VTE in pediatric patients from birth (at least 35 weeks gestational age) onward. Fragmin is not intended for the acute (immediate emergency) treatment of VTE.

See full Dalteparin Injection drug information
Keep checking

Other Drugs & Inositol Nicotinate

Browse every other medication we’ve checked against Inositol Nicotinate — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
222Moderate
0Minor
2,607No known interaction
222 Moderate 2,607 No interaction
Moderate

222 interactions

Showing 60 of 222 moderate interactions — see all 222 on the Inositol Nicotinate page.

No interaction 2,607 drugs checked — show the list

We also checked Inositol Nicotinate against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,607 medications checked with no known interaction — see the full Inositol Nicotinate list.

See the full Inositol Nicotinate interactions page
See every supplement checked against Dalteparin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Inositol Nicotinate monograph › Uses, safety, and every drug interaction in one place Dalteparin supplement interactions › Every supplement checked against Dalteparin, ranked by severity Dalteparin Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Inositol Nicotinate and Dalteparin Together: Common Questions

Can you take Inositol Nicotinate with Dalteparin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Inositol Nicotinate and Dalteparin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dalteparin and Inositol Nicotinate?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.