Maitake Mushroom + Selumetinib Sulfate

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

• A skin rash / Itching reported in 12.8% of FDA reports for Selumetinib Sulfate Additional detail

  Maitake Mushroom

  “In a clinical trial, one patient experienced rash and pruritus after two doses of maitake mushroom polysaccharide extract. The allergic reaction cleared without intervention.”

  Maitake Mushroom · Natural Medicines adverse-effect record, reported in pruritus.

  1 source cited

  1. 61239. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i

  Selumetinib Sulfate

  Listed in the ADVERSE REACTIONS section of the FDA label for Selumetinib Sulfate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

• Diarrhea reported in 4.9% of FDA reports for Selumetinib Sulfate Additional detail

  Maitake Mushroom

  “In clinical research of a polysaccharide extract from maitake mushroom, one patient reported nausea and 2 out of 26 reported epigastric pain. In a clinical trial of a liquid extract from maitake mushroom, 2 out of 21 patients experienced diarrhea, and one experienced nausea. One patient withdrew from the study due to diarrhea.”

  Maitake Mushroom · Natural Medicines adverse-effect record, reported in diarrhea.

  3 sources cited

  1. 61239. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  2. 17131. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  3. 92843. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed ↗

  Selumetinib Sulfate

  Listed in the ADVERSE REACTIONS section of the FDA label for Selumetinib Sulfate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

• Nausea reported in 4.7% of FDA reports for Selumetinib Sulfate Additional detail

  Maitake Mushroom

  Recorded for Maitake Mushroom in the same Natural Medicines adverse-effect record shown under Diarrhea above.

  Selumetinib Sulfate

  Listed in the ADVERSE REACTIONS section of the FDA label for Selumetinib Sulfate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Maitake Mushroom but not commonly for Selumetinib Sulfate: an allergic reaction.

Effects for Selumetinib Sulfate come from the ADVERSE REACTIONS section of its FDA label; effects for Maitake Mushroom come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,381 voluntary FDA FAERS reports for Selumetinib Sulfate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.