Drug & supplement interaction

Noni + Acetaminophen, Dexbrompheniramine, Pseudoephedrine

Acetaminophen, Dexbrompheniramine, Pseudoephedrine brand name: Sinadrin Plus.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Noni has a moderate interaction with Acetaminophen, Dexbrompheniramine, Pseudoephedrine. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Noni and Acetaminophen, Dexbrompheniramine, Pseudoephedrine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

HEPATOTOXIC DRUGS

Why this applies to Acetaminophen, Dexbrompheniramine, Pseudoephedrine

Acetaminophen, Dexbrompheniramine, Pseudoephedrine falls under HEPATOTOXIC DRUGS — the group Noni interacts with.

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

The piece of this combo product that matters here is the acetaminophen (the same ingredient as Tylenol). Your liver does the heavy lifting of breaking it down, and in high doses acetaminophen can stress the liver on its own. Noni has been linked, in a handful of case reports, to liver trouble in some people. So the worry is simple: two things that can each be hard on the liver, taken together, might add up.

To be honest, this is a theoretical, anecdotal concern, not something proven, and an occasional glass of noni juice with a normal dose of cold medicine is unlikely to cause harm. Still, if you drink noni regularly, take acetaminophen often, or have any liver issues, please run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  2. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  3. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Noni Also Interacts With Other Medications

Noni has 540 moderate, 1 minor known drug interactions in our database — the Acetaminophen, Dexbrompheniramine, Pseudoephedrine one above is one of them. If you take anything else, check it against the full list below.

Moderate 540 Minor 1 No known interaction 2,289 (incl. Acetaminophen, Dexbrompheniramine, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against Noni

Covers the 2,830 medications we’ve checked against Noni. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Dexbrompheniramine, Pseudoephedrine

This page covers Noni only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dexbrompheniramine, Pseudoephedrine page lists 217 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Peyote (major).

By severity: 9 major · 169 moderate · 39 minor.

From our pharmacist’s overview on the Acetaminophen, Dexbrompheniramine, Pseudoephedrine page

“Sinadrin Plus (acetaminophen, dexbrompheniramine, and pseudoephedrine) deserves real care around supplements, mostly because pseudoephedrine is a stimulant and acetaminophen taxes the liver. Nine of the 217 ingredients on file carry a major rating, and they cluster around those two risks: ephedra and similar herbs can pile onto the sti…”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Dexbrompheniramine, Pseudoephedrine interaction page

One more smart check

Taking Noni as Part of a Dietary Supplement Product? Check It for Interactions

We hold 727 real supplement products containing Noni, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Noni. Your product may carry other ingredients that interact with Acetaminophen, Dexbrompheniramine, Pseudoephedrine too, on top of Noni — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Noni and Acetaminophen, Dexbrompheniramine, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Noni
Top 25%

#288 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Dexbrompheniramine, Pseudoephedrine
Top half

#1,113 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Noni

What is Noni?

Noni
  • General wellness and energy
  • Inflammation and joint pain
  • Immune support
  • High blood pressure
  • Skin and wound care
  • Digestive complaints

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake is generally well tolerated, there are rare reports of liver problems, and it should be avoided in pregnancy and breastfeeding. Talk with your pharmacist or doctor before using it, especially if you have kidney or liver disease.

Read the full Noni monograph & all interactions
Keep checking

Other Drugs & Noni

Browse every other medication we’ve checked against Noni — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
540Moderate
1Minor
2,288No known interaction
540 Moderate 1 Minor 2,288 No interaction
Moderate

540 interactions

Showing 60 of 540 moderate interactions — see all 540 on the Noni page.

Minor

1 interaction

No interaction 2,288 drugs checked — show the list

We also checked Noni against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,288 medications checked with no known interaction — see the full Noni list.

See the full Noni interactions page
See every supplement checked against Acetaminophen, Dexbrompheniramine, Pseudoephedrine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Noni monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Dexbrompheniramine, Pseudoephedrine supplement interactions › Every supplement checked against Acetaminophen, Dexbrompheniramine, Pseudoephedrine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Noni and Acetaminophen, Dexbrompheniramine, Pseudoephedrine Together: Common Questions

Can you take Noni with Acetaminophen, Dexbrompheniramine, Pseudoephedrine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Noni and Acetaminophen, Dexbrompheniramine, Pseudoephedrine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetaminophen, Dexbrompheniramine, Pseudoephedrine and Noni?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.