Saw Palmetto - Mestranol, Norethindrone Interaction
Herbal: Saw Palmetto
Also Known As: Serenoa repens, American Dwarf Palm Tree, Baies du Palmier Scie, Cabbage Palm, Chou Palmiste, Ju-Zhong, Palmier Nain, Palmier Scie, Sabal, Sabal Fructus, Saw Palmetto Berry
Drug: Mestranol, Norethindrone
Brand names:
Necon 1/50, Ortho Novum 21, Ortho-Novum 1/50-28, Norinyl 1 50 21 Day, Ortho Novum 1 Plus 50, Norethin 1/50, Nelova 1/50M, Norethin 1/50M

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Mestranol, Norethindrone is classified as belonging to the following category: Contraceptive Drugs
Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Pharmacist Analysis
There is evidence to suggest that saw palmetto, a commonly used herbal supplement, may reduce the effectiveness of contraceptive drugs due to the herb's potential antiestrogenic effects, which may interfere with the hormonal balance needed for effective contraception.
Contraceptive drugs work by regulating hormones in the body, preventing ovulation, and creating an unfavorable environment for fertilization. However, when saw palmetto is taken concomitantly, it may interfere with these hormonal processes, reducing the effectiveness of the contraceptive drugs.
While there is still much research to be done on the potential interactions between saw palmetto and contraceptive drugs, it is important to speak with a healthcare provider before taking any new supplements or making changes to current medications.
There is evidence to suggest that saw palmetto, a commonly used herbal supplement, may reduce the effectiveness of contraceptive drugs due to the herb's potential antiestrogenic effects, which may interfere with the hormonal balance needed for effective contraception.
Contraceptive drugs work by regulating hormones in the body, preventing ovulation, and creating an unfavorable environment for fertilization. However, when saw palmetto is taken concomitantly, it may interfere with these hormonal processes, reducing the effectiveness of the contraceptive drugs.
While there is still much research to be done on the potential interactions between saw palmetto and contraceptive drugs, it is important to speak with a healthcare provider before taking any new supplements or making changes to current medications.
There is evidence to suggest that saw palmetto, a commonly used herbal supplement, may reduce the effectiveness of contraceptive drugs due to the herb's potential antiestrogenic effects, which may interfere with the hormonal balance needed for effective contraception.
Contraceptive drugs work by regulating hormones in the body, preventing ovulation, and creating an unfavorable environment for fertilization. However, when saw palmetto is taken concomitantly, it may interfere with these hormonal processes, reducing the effectiveness of the contraceptive drugs.
While there is still much research to be done on the potential interactions between saw palmetto and contraceptive drugs, it is important to speak with a healthcare provider before taking any new supplements or making changes to current medications.
References
- Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14.
Saw Palmetto Overview

Saw Palmetto - More Interactions
Saw Palmetto interacts with 173 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.