Schizonepeta + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine
Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine brand names: Robitussin Cold, Suphedrine Cold/Cough, Severe Cold.
Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine falls into 4 drug categories that Schizonepeta can interact with; the most serious is rated moderate. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2D6.
Read the full interaction reportSchizonepeta and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Schizonepeta interacts with whole categories of medication. Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine falls into 4 of those categories, so it can interact with Schizonepeta in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 4Why this applies to Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine
Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Schizonepeta interacts with.
Some substrates of CYP2D6 include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Of the four ingredients in this combo cold product, the one that matters here is dextromethorphan, the cough suppressant. Your body relies on an enzyme called CYP2D6 to break it down. Lab and animal studies hint that a compound in Schizonepeta may slow that enzyme, so in theory dextromethorphan could build up a bit and hit harder. That might mean more drowsiness, dizziness, or a foggy, lightheaded feeling. The other three (acetaminophen, guaifenesin, and pseudoephedrine) aren't really cleared this way.
I want to be honest about how thin this evidence is. It comes only from test-tube and animal work, not people, so the real-world risk is probably small. Still, if you plan to use both regularly, it's worth a quick chat with your pharmacist or doctor first.
- Bao B, Geng T, Cao Y, et al. Effects of schizonepetin on activity of mRNA expression of cytochrome P450 enzymes in rats. Int J Mol Sci. 2012;13(12):17006-18.
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
2 of 4Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
Some substrates of CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combo cold product has four ingredients, and the one most likely to notice a CYP1A2 change is dextromethorphan, the cough suppressant. Schizonepeta may mildly slow that enzyme, so in theory dextromethorphan could clear a bit more slowly and build up, nudging up side effects like dizziness, drowsiness, or a foggy, lightheaded feeling. The acetaminophen, guaifenesin, and pseudoephedrine pieces aren't really driven by CYP1A2, so they shouldn't change much.
Here's the honest part: this concern comes only from animal and lab data, not human studies, so it's theoretical and probably small. None of these are prodrugs that flip the effect. Still, if you take Schizonepeta supplements regularly, mention it to your pharmacist before pairing it with this medicine.
- Bao B, Geng T, Cao Y, et al. Effects of schizonepetin on activity of mRNA expression of cytochrome P450 enzymes in rats. Int J Mol Sci. 2012;13(12):17006-18.
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
3 of 4Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Some substrates of CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combo cold product has four ingredients, and only one of them, dextromethorphan (the cough suppressant), leans much on CYP3A4 to be broken down. The concern on file is that schizonepeta may speed up that enzyme, so in theory it could clear dextromethorphan a bit faster and make your cough medicine feel slightly less effective. The acetaminophen, guaifenesin, and pseudoephedrine pieces aren't really driven by this pathway, so they're less of an issue here.
Honestly, this is a weak signal. It comes only from lab and animal studies, not from people, so I wouldn't lose sleep over it. Still, if you regularly use schizonepeta, mention it to your pharmacist so they can keep an eye on things.
- Bao B, Geng T, Cao Y, et al. Effects of schizonepetin on activity of mRNA expression of cytochrome P450 enzymes in rats. Int J Mol Sci. 2012;13(12):17006-18.
CYTOCHROME P450 2E1 (CYP2E1) SUBSTRATES
4 of 4Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine also falls under CYTOCHROME P450 2E1 (CYP2E1) SUBSTRATES.
Some substrates of CYP2E1 include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane).
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The piece of this combo cold product that matters here is the acetaminophen (the Tylenol-type ingredient). An enzyme in your liver called CYP2E1 helps handle acetaminophen. In lab and animal studies only, a compound in Schizonepeta appears to slow that enzyme down. In theory, that could let a bit more acetaminophen linger in your body, which is mostly a concern for the liver if doses are high or taken often.
Now the honest part: this is very early evidence, just test tube and animal work, so the real-world effect in people is unknown and may be small. The other ingredients (dextromethorphan, guaifenesin, pseudoephedrine) are not really the issue here. Still, since acetaminophen and your liver deserve respect, run this combo by your pharmacist or doctor first, and never double up on acetaminophen products.
- Bao B, Geng T, Cao Y, et al. Effects of schizonepetin on activity of mRNA expression of cytochrome P450 enzymes in rats. Int J Mol Sci. 2012;13(12):17006-18.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Schizonepeta Also Interacts With Other Medications
Schizonepeta has 798 moderate known drug interactions in our database — the Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Schizonepeta
We haven’t checked that one against Schizonepeta yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Schizonepeta. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine
This page covers Schizonepeta only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine page lists 262 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).
By severity: 12 major · 207 moderate · 43 minor.
Open the Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interaction page
Taking Schizonepeta as Part of a Dietary Supplement Product? Check It for Interactions
We hold 285 real supplement products containing Schizonepeta, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Schizonepeta. Your product may carry other ingredients that interact with Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine too, on top of Schizonepeta — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Schizonepeta and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#404 of 1,452 supplements looked up here in the last 7 days
#112 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Schizonepeta
What is Schizonepeta?
- Common cold and early-stage fever
- Itchy skin rashes and hives
- Sore throat
- Headache
- Measles and other skin eruptions (traditional use)
Schizonepeta is a mint-family herb long used in traditional Chinese medicine, usually as part of combination formulas for colds, fevers, and itchy skin conditions. Modern human evidence is very limited, so its benefits are not well proven. Talk to a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.
Other Drugs & Schizonepeta
Browse every other medication we’ve checked against Schizonepeta — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
798 interactions
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Oxybutynin ›
- Oxycodone ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Miconazole ›
- Morphine Sulfate ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Nortriptyline ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Bendamustine ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
- Doxepin ›
- Duloxetine ›
- Erythromycin Ethylsuccinate ›
Showing 60 of 798 moderate interactions — see all 798 on the Schizonepeta page.
No interaction 2,031 drugs checked — show the list
We also checked Schizonepeta against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Aspirin ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Metformin ›
- Valacyclovir ›
- Hydroxyurea ›
- Semaglutide ›
- Sumatriptan ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Acetylsalicylic Acid ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Insulin Degludec, Liraglutide ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Atenolol, Chlorthalidone ›
- Aspirin, Butalbital ›
- Aminophylline, Amobarbital, Ephedrine ›
- Enalapril Maleate ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Canagliflozin, Metformin ›
- Ezetimibe ›
- Ephedrine, Phenobarbital, Theophylline ›
- Cephalexin ›
- Sacubitril, Valsartan ›
- Cyclopentolate ›
- Levetiracetam ›
- Levodopa ›
- Rosiglitazone Maleate ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Daunorubicin, Cytarabine ›
- Carbidopa, Levodopa ›
- Sulfamethoxazole, Trimethoprim ›
- Thyroid Hormone ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Bupivacaine, Meloxicam ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Amobarbital, Ephedrine Sulfate ›
- Aspirin, Ethoheptazine, Meprobamate ›
- Mannitol ›
- Alginic Acid, Aluminum Hydroxide ›
Showing the 60 most looked-up of 2,031 medications checked with no known interaction — see the full Schizonepeta list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine as a medicine that can lower these. This is not an interaction with Schizonepeta — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Schizonepeta and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine Together: Common Questions
Can you take Schizonepeta with Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine?
Why are there 4 interactions listed for Schizonepeta and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine?
How serious is the Schizonepeta and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.