Drug & supplement interaction

Spearmint + Ivermectin

Ivermectin brand names: Stromectol, Mectizan, Sklice, Soolantra.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Spearmint and Ivermectin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ivermectin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Spearmint and Ivermectin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ivermectin and Spearmint in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Spearmint safety at a glance

Spearmint overall Use caution Generally safe as food or tea, but concentrated supplements and oils need more caution.
Pregnancy Likely Safe When used in the amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When used in the amounts commonly found in foods. There is insufficient reliable information available about the safety of spearmint during lactation. Avoid usi... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ivermectin and Spearmint? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ivermectin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ivermectin is filed under 4 classifications — including topical drugs, p-glycoprotein substrates, oral drugs. Spearmint has documented interactions with 2 drug classes — the most serious being cns depressants (moderate) and hepatotoxic drugs (moderate) — and none of Ivermectin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Spearmint Does Interact With Other Medications

Spearmint has 579 moderate known drug interactions in our database — Ivermectin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 579 No known interaction 2,251 (incl. Ivermectin)
Taking anything else?

Check Another of Your Medications Against Spearmint

Covers the 2,830 medications we’ve checked against Spearmint. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Spearmint and Ivermectin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A fast or pounding heartbeat Additional detail

    Spearmint

    “Orally, taking spearmint extract 600 mg daily has been associated with one report of tachycardia in one clinical trial. However, it is not certain that this adverse event was caused by spearmint extract.”

    Spearmint · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 94925. Lasrado JA, Nieman KM, Fonseca BA, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol 2017;86:167-176. PubMed

    Ivermectin

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivermectin. Read the label on DailyMed ›

  • Constipation / Diarrhea reported in 4.6% of FDA reports for Ivermectin Additional detail

    Spearmint

    “Orally, taking spearmint extract 600 mg daily has been associated with dyspepsia in one clinical trial. Taking a higher dose of 900 mg daily has been associated with diarrhea and belching. Drinking 2 cups of spearmint tea with normal amounts of rosmarinic acid has been associated with one report of dry mouth in clinical research.”

    Spearmint · Natural Medicines adverse-effect record, reported in constipation.

    3 sources cited
    1. 94925. Lasrado JA, Nieman KM, Fonseca BA, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol 2017;86:167-176. PubMed
    2. 94923. Connelly AE, Tucker AJ, Tulk H, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 2014;17:1361-7. PubMed
    3. 75700. Bulat, R., Fachnie, E., Chauhan, U., Chen, Y., and Tougas, G. Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers. Aliment.Pharmacol Ther. 1999;13(6):805-812. PubMed

    Ivermectin

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivermectin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Swelling Additional detail

    Spearmint

    “Topically, spearmint oil and leaves have caused allergic dermatitis. Allergic contact cheilitis has also occurred from spearmint oil in toothpaste or chewing gum. Spearmint oil inhalation has also caused allergic dermatitis. Orally, spearmint leaves have caused allergy-associated swelling of the soft palate. A specific 50 KDa protein in the spearmint was found to be the responsible allergen.”

    Spearmint · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 75711. Bonamonte, D., Mundo, L., Daddabbo, M., and Foti, C. Allergic contact dermatitis from Mentha spicata (spearmint). Contact Dermatitis 2001;45(5):298.
    2. 75731. Tomson, N., Murdoch, S., and Finch, T. M. The dangers of making mint sauce. Contact Dermatitis 2004;51(2):92-93. PubMed
    3. 75737. Clayton, R. and Orton, D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis 2004;51(5-6):314-315. PubMed
    4. 31403. Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
    5. 31528. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
    6. 75706. Francalanci, S., Sertoli, A., Giorgini, S., Pigatto, P., Santucci, B., and Valsecchi, R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis 2000;43(4):216-222. PubMed

    Ivermectin

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivermectin. Read the label on DailyMed ›

  • Headache reported in 10.3% of FDA reports for Ivermectin Additional detail

    Spearmint

    “Orally, drinking 2 cups of spearmint tea containing high amounts of rosmarinic acid has been associated with two reports of headache in clinical research.”

    Spearmint · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 94923. Connelly AE, Tucker AJ, Tulk H, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 2014;17:1361-7. PubMed

    Ivermectin

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivermectin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Spearmint

    “Orally, spearmint is well tolerated.

    Most Common Adverse Effects:

    Topically: Allergic contact dermatitis or cheilitis in sensitive individuals.”

    Spearmint · Natural Medicines adverse-effect record, reported in dermatitis.

    Ivermectin

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivermectin. Read the label on DailyMed ›

Reported for Spearmint but not commonly for Ivermectin: increased appetite, weight gain, stomach upset and dry mouth.

Effects for Ivermectin come from the ADVERSE REACTIONS section of its FDA label; effects for Spearmint come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 6,298 voluntary FDA FAERS reports for Ivermectin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Spearmint in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used in the amounts commonly found in foods.

Pregnancy Possibly Unsafe

When used orally during pregnancy in excessive amounts. Animal research suggests that spearmint tea may cause uterine damage. Avoid using in amounts greater than those typically found in foods during pregnancy.

Lactation Likely Safe

When used in the amounts commonly found in foods. There is insufficient reliable information available about the safety of spearmint during lactation. Avoid using in amounts greater than those typically found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Ivermectin Products Have a Food Rule — Spearmint Should Not Break It

At least one FDA label for a product containing Ivermectin says to take it on an empty stomach. Most supplements — Spearmint included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Ivermectin on its own and move Spearmint to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ivermectin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Patients should take tablets on an empty stomach with water.

From the Dosage and Administration section of the FDA label we read for Ivermectin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Spearmint or Ivermectin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Spearmint or Ivermectin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ivermectin

This page covers Spearmint only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ivermectin page lists 58 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Sweet Orange (major), Bitter Melon (moderate) and Black Pepper (moderate).

By severity: 3 major · 37 moderate · 18 minor.

Open the Ivermectin interaction page

One more smart check

Taking Spearmint as Part of a Dietary Supplement Product? Check It for Interactions

We hold 408 real supplement products containing Spearmint, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Spearmint. Even though Spearmint itself has no known interaction with Ivermectin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Spearmint and Ivermectin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Spearmint
Top 25%

#332 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ivermectin
Top 1%

#12 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Spearmint reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Spearmint and Ivermectin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Spearmint

What is Spearmint?

Spearmint
  • Digestive upset and indigestion
  • Nausea
  • Hormonal acne and unwanted hair (PCOS-related)
  • Memory and focus
  • Mild stress and anxiety
  • Joint discomfort

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facial hair in women), and memory, but the evidence is still limited. Talk to your pharmacist or doctor before using concentrated supplements, especially if you are pregnant or have a health condition.

Mentha spicata · Lamiaceae · Leaves and essential oil · Tea, capsules, dried leaf, essential oil, extract

An interaction check asks whether these two react with each other — it does not ask whether Spearmint is a good idea for someone in your situation. Here is what our Spearmint record says about it on its own.

Spearmint: dosing

There is no official standard dose for spearmint. In research, people have used it as a cup of tea once or twice a day, or as standardized extracts in capsules. Because products vary widely in strength, it is best to follow the directions on the product label.Spearmint supplements are sometimes standardized to a certain amount of rosmarinic acid. Start low and watch how your body responds.

From our Spearmint monograph — the full record covers uses, side effects and every documented interaction.

Read the full Spearmint monograph & all interactions
Medication

About Ivermectin

What Is Ivermectin Used For?

Brand names: Stromectol, Mectizan, Sklice, Soolantra

Ivermectin tablets (including Stromectol) are used to treat two parasitic infections: strongyloidiasis (a roundworm infection of the intestinal tract) and onchocerciasis (river blindness, caused by a parasitic worm spread by blackfly bites). These are prescription uses for serious infections.

Topical ivermectin lotion — sold under several names including RID One and Done, Head Lice Treatment Ivermectin Lotion, Scalp Care Lotions, and others — is applied to the scalp to treat head lice. A separate topical ivermectin cream (1%), available as Soolantra and ivermectin cream 1%, is used to treat the inflammatory pimple-like bumps of rosacea.

Most-Reported Side Effects for Ivermectin

From FAERS, the FDA’s public side-effect reporting system (6,298 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 647 reports
Asthenia 590 reports
Fever 485 reports
Pruritus 388 reports
Diarrhea 292 reports
See full Ivermectin drug information
Keep checking

Other Drugs & Spearmint

Browse every other medication we’ve checked against Spearmint — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
579Moderate
0Minor
2,250No known interaction
579 Moderate 2,250 No interaction
Moderate

579 interactions

Showing 60 of 579 moderate interactions — see all 579 on the Spearmint page.

No interaction 2,250 drugs checked — show the list

We also checked Spearmint against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,250 medications checked with no known interaction — see the full Spearmint list.

See the full Spearmint interactions page
See every supplement checked against Ivermectin, ranked by severity
Evidence & sources

Spearmint References

The 20 references that drive our Spearmint monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Akdogan M, Ozguner M, Aydin G, Gokalp O. Investigation of biochemical and histopathological effects of Mentha piperita Labiatae and Mentha spicata Labiatae on liver tissue in rats. Hum Exp Toxicol 2004;23:21-8.
  3. Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
  4. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  5. de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268.
  6. Larsen, W., Nakayama, H., Fischer, T., Elsner, P., Frosch, P., Burrows, D., Jordan, W., Shaw, S., Wilkinson, J., Marks, J., Jr., Sugawara, M., Nethercott, M., and Nethercott, J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II PubMed
  7. Guney, M., Oral, B., Karahanli, N., Mungan, T., and Akdogan, M. The effect of Mentha spicata Labiatae on uterine tissue in rats. Toxicol.Ind.Health 2006;22(8):343-348.
  8. Masumoto, Y., Morinushi, T., Kawasaki, H., Ogura, T., and Takigawa, M. Effects of three principal constituents in chewing gum on electroencephalographic activity. Psychiatry Clin.Neurosci. 1999;53(1):17-23. PubMed
  9. Bulat, R., Fachnie, E., Chauhan, U., Chen, Y., and Tougas, G. Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers. Aliment.Pharmacol Ther. 1999;13(6):805-812. PubMed
  10. Francalanci, S., Sertoli, A., Giorgini, S., Pigatto, P., Santucci, B., and Valsecchi, R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis 2000;43(4):216-222. PubMed
  11. Bonamonte, D., Mundo, L., Daddabbo, M., and Foti, C. Allergic contact dermatitis from Mentha spicata (spearmint). Contact Dermatitis 2001;45(5):298.
  12. Tomson, N., Murdoch, S., and Finch, T. M. The dangers of making mint sauce. Contact Dermatitis 2004;51(2):92-93. PubMed
  13. Clayton, R. and Orton, D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis 2004;51(5-6):314-315. PubMed
  14. Dal Sacco, D., Gibelli, D., and Gallo, R. Contact allergy in the burning mouth syndrome: a retrospective study on 38 patients. Acta Derm.Venereol. 2005;85(1):63-64. PubMed
  15. Goncalves, J. C., Oliveira, Fde S., Benedito, R. B., de Sousa, D. P., de Almeida, R. N., and de Araujo, D. A. Antinociceptive activity of (-)-carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull. 2008;31(5):1017- PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Spearmint and Ivermectin Together: Common Questions

Is it safe to take Spearmint with Ivermectin?
We do not list a known interaction between Spearmint and Ivermectin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Spearmint and Ivermectin have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Spearmint and Ivermectin at the same time of day?
At least one FDA label for a product containing Ivermectin says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Ivermectin on its own and move Spearmint to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Spearmint and Ivermectin combination checked?
Interactions in our licensed database are recorded against drug classes. Ivermectin is filed under 4 classifications, and Spearmint has documented interactions with 2 drug classes — none of Ivermectin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Spearmint interact with any other medications?
Yes. Spearmint has 579 documented drug interactions in our database — Ivermectin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ivermectin interact with any supplements?
Yes. Ivermectin has documented interactions with 58 supplements in our database — Spearmint is not one of them. The Ivermectin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Spearmint monograph Uses, safety profile, and every drug interaction in one place Ivermectin drug information The full plain-English guide to this medication Ivermectin supplement interactions Every supplement checked against Ivermectin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ivermectin and Spearmint?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.