Drug & supplement interaction

Testolone + Everolimus

Everolimus brand names: Certican, Afinitor, Zortress, Afinitor Disperz.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Testolone and Everolimus in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Testolone and Everolimus

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Everolimus and Testolone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Testolone safety at a glance

Testolone overall Avoid Testolone is an unapproved experimental drug with reported serious risks and should not be used.
Pregnancy Possibly Unsafe When used orally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen receptor modul... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen receptor modul... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Everolimus and Testolone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Everolimus

Interactions in our licensed database are recorded against drug classes, not just single drug names. Everolimus is filed under 7 classifications — including cytochrome p450 2d6 (cyp2d6) inhibitors, cytochrome p450 3a4 (cyp3a4) inhibitors, p-glycoprotein substrates. Testolone has documented interactions with 1 drug class — the most serious being hepatotoxic drugs (moderate) — and none of Everolimus’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Testolone Does Interact With Other Medications

Testolone has 370 moderate known drug interactions in our database — Everolimus isn’t one of them. If you take anything else, check it against the full list below.

Moderate 370 No known interaction 2,460 (incl. Everolimus)
Taking anything else?

Check Another of Your Medications Against Testolone

Covers the 2,830 medications we’ve checked against Testolone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Testolone and Everolimus May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 4 of them are worth acting on rather than waiting out — marked below.

  • Dehydration Worth acting on Additional detail

    Testolone

    “A dose escalation study of testolone 50-150 mg daily for about 8 weeks found that some of the most common treatment-emergent adverse events included dehydration and decreased weight. Conversely, one patient in a clinical study experienced weight gain, which was thought to be related or possibly related to the use of oral testolone 100 mg daily for about 8 weeks.”

    Testolone · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 108159. LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77. PubMed

    Everolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Everolimus. Read the label on DailyMed ›

  • A heart attack / Shortness of breath Worth acting on reported in 5.2% of FDA reports for Everolimus Additional detail

    Testolone

    “Acute myocarditis presumably associated with testolone has been reported in a 32-year-old male who used the product for athletic performance enhancement. The patient presented with shortness of breath and a mild fever, with elevations in troponin I, B-type natriuretic peptide, erythrocyte sedimentation rate, C-reactive protein, and D-dimer and received treatment with aspirin, atorvastatin, carvedilol, and furosemide,…”

    Testolone · Natural Medicines adverse-effect record, reported in athletic performance.

    5 sources cited
    1. 108161. Padappayil RP, Chandini Arjun A, Vivar Acosta J, Ghali W, Mughal MS. Acute myocarditis from the use of selective androgen receptor modulator (SARM) RAD-140 (Testolone). Cureus. 2022;14(1):e21663. PubMed
    2. 94879. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
    3. 94880. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
    4. 94881. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
    5. 108159. LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77. PubMed

    Everolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Everolimus, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Testolone

    “A dose escalation study of testolone 50-150 mg daily for about 8 weeks found that the most common treatment-emergent adverse events included moderate elevations in aspartate aminotransferase (AST), alanine aminotransferase (ALT), and bilirubin.”

    Testolone · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 108159. LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77. PubMed
    2. 108160. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
    3. 94879. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
    4. 94880. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
    5. 94881. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017

    Everolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Everolimus. Read the label on DailyMed ›

  • Weight loss Additional detail

    Testolone

    Recorded for Testolone in the same Natural Medicines adverse-effect record shown under Dehydration above.

    Everolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Everolimus. Read the label on DailyMed ›

  • Reduced appetite / Vomiting Additional detail

    Testolone

    “Orally, vomiting and decreased appetite were reported to be some of the most common adverse effects in a dose escalation study of testolone 50-150 mg daily for about 8 weeks.”

    Testolone · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 108159. LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77. PubMed

    Everolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Everolimus. Read the label on DailyMed ›

  • Fever Additional detail

    Testolone

    Recorded for Testolone in the same Natural Medicines adverse-effect record shown under A heart attack / Shortness of breath above.

    Everolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Everolimus. Read the label on DailyMed ›

  • Diarrhea / Itching reported in 8.1% of FDA reports for Everolimus Additional detail

    Testolone

    Recorded for Testolone in the same Natural Medicines adverse-effect record shown under Liver problems above.

    Everolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Everolimus, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Testolone but not commonly for Everolimus: a fast or pounding heartbeat, weight gain, yellowing of the skin or eyes and acne.

Effects for Everolimus come from the ADVERSE REACTIONS section of its FDA label; effects for Testolone come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 50,590 voluntary FDA FAERS reports for Everolimus that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Testolone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen receptor modulators (SARMs) are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Everolimus Is Prescribed For, and What Testolone Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Everolimus is a prescription medicine with approved uses on its FDA label. Testolone is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Everolimus is prescribed for: Everolimus is used to treat several serious conditions. In cancer, it is prescribed for advanced hormone receptor-positive, HER2-negative breast cancer (in postmenopausal women), certain neuroendocrine tumors of the pancreas, GI tract, or lung, and advanced renal cell carcinoma (kidney cancer) when other treatments have stopped working. It is also used for people with tuberous sclerosis complex (TSC) — a genetic condition that causes benign tumors to grow throughout the body. In TSC, it treats kidney tumors called angiomyolipomas, brain tumors called SEGA, and seizures.

Read the rest of what Everolimus is prescribed for

In kidney transplant patients, it helps prevent the body from rejecting the new organ.

Testolone has been studied for:

  • Breast cancer studied, not established Testolone has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Testolone for breast cancer

    Although there is interest in using oral testolone for breast cancer, there is insufficient reliable information about the clinical effects of testolone for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Everolimus on your own; if you are taking Testolone for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Everolimus

This page covers Testolone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Everolimus page lists 156 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 5 major · 112 moderate · 39 minor.

From our pharmacist’s overview on the Everolimus page

“Everolimus (Afinitor, Zortress, Certican) has to stay in a narrow blood-level window, whether you take it after an organ transplant or for cancer, so treat this supplement list with real caution. Most of its 156 interacting ingredients can push those levels up or down, mainly by changing how the CYP3A4 enzyme breaks the drug down.”

Reviewed by 2 · Jul 18, 2026

Open the Everolimus interaction page

One more smart check

Taking Testolone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Testolone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Testolone. Even though Testolone itself has no known interaction with Everolimus, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Testolone and Everolimus Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Testolone
Steady interest

#833 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Everolimus
Top 25%

#635 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Testolone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Testolone and Everolimus records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Testolone

What is Testolone?

  • Muscle building
  • Athletic performance and bodybuilding
  • Strength gains
  • Body recomposition (fat loss with muscle gain)

Testolone (RAD-140) is a synthetic experimental drug called a selective androgen receptor modulator (SARM), not a dietary supplement or herb, and it is not approved or proven safe for human use. It is illegally sold for muscle building, has been linked to serious harms including liver injury, and is banned in sports — it should not be taken outside of supervised clinical research.

Synthetic compound (not a plant); supplied as a chemical powder or liquid · Capsules, tablets, liquids, and powders sold as 'research chemicals'

An interaction check asks whether these two react with each other — it does not ask whether Testolone is a good idea for someone in your situation. Here is what our Testolone record says about it on its own.

Testolone: dosing

There is no established safe or approved dose of Testolone. It has not gone through the testing needed to set safe dosing guidelines for people.Doses listed on illegally sold products are not verified, and the actual content of these products is often unreliable. For these reasons, we do not provide dosing information.The safest choice is not to use Testolone.

From our Testolone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Testolone monograph & all interactions
Medication

About Everolimus

What Is Everolimus Used For?

Brand names: Certican, Afinitor, Zortress, Afinitor Disperz

Everolimus is used to treat several serious conditions. In cancer, it is prescribed for advanced hormone receptor-positive, HER2-negative breast cancer (in postmenopausal women), certain neuroendocrine tumors of the pancreas, GI tract, or lung, and advanced renal cell carcinoma (kidney cancer) when other treatments have stopped working.

It is also used for people with tuberous sclerosis complex (TSC) — a genetic condition that causes benign tumors to grow throughout the body. In TSC, it treats kidney tumors called angiomyolipomas, brain tumors called SEGA, and seizures. In kidney transplant patients, it helps prevent the body from rejecting the new organ.

Most-Reported Side Effects for Everolimus

From FAERS, the FDA’s public side-effect reporting system (50,590 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 4,681 reports
Diarrhea 4,073 reports
Fatigue 3,810 reports
Stomatitis 3,190 reports
Nausea 2,854 reports
See full Everolimus drug information
Keep checking

Other Drugs & Testolone

Browse every other medication we’ve checked against Testolone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
370Moderate
0Minor
2,459No known interaction
370 Moderate 2,459 No interaction
Moderate

370 interactions

Showing 60 of 370 moderate interactions — see all 370 on the Testolone page.

No interaction 2,459 drugs checked — show the list

We also checked Testolone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,459 medications checked with no known interaction — see the full Testolone list.

See the full Testolone interactions page
See every supplement checked against Everolimus, ranked by severity
Evidence & sources

Testolone References

The 7 references that drive our Testolone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  3. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  4. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  5. LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77. PubMed
  6. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
  7. Padappayil RP, Chandini Arjun A, Vivar Acosta J, Ghali W, Mughal MS. Acute myocarditis from the use of selective androgen receptor modulator (SARM) RAD-140 (Testolone). Cureus. 2022;14(1):e21663. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Testolone and Everolimus Together: Common Questions

Is it safe to take Testolone with Everolimus?
We do not list a known interaction between Testolone and Everolimus. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Testolone and Everolimus have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Testolone and Everolimus used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Testolone in each. That is a conversation for your prescriber, especially if Everolimus is being adjusted to a target.
How was the Testolone and Everolimus combination checked?
Interactions in our licensed database are recorded against drug classes. Everolimus is filed under 7 classifications, and Testolone has documented interactions with 1 drug class — none of Everolimus's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Testolone interact with any other medications?
Yes. Testolone has 370 documented drug interactions in our database — Everolimus is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Everolimus interact with any supplements?
Yes. Everolimus has documented interactions with 156 supplements in our database — Testolone is not one of them. The Everolimus interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Testolone monograph Uses, safety profile, and every drug interaction in one place Everolimus drug information The full plain-English guide to this medication Everolimus supplement interactions Every supplement checked against Everolimus, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Everolimus and Testolone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.