Tree Turmeric + Celecoxib, Tramadol
Celecoxib, Tramadol brand name: Seglentis.
Celecoxib, Tramadol falls into 4 drug categories that Tree Turmeric can interact with; the most serious is rated moderate. Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full interaction reportTree Turmeric and Celecoxib, Tramadol
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Tree Turmeric interacts with whole categories of medication. Celecoxib, Tramadol falls into 4 of those categories, so it can interact with Tree Turmeric in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CNS DEPRESSANTS
1 of 4Why this applies to Celecoxib, Tramadol
Celecoxib, Tramadol falls under CNS DEPRESSANTS — the group Tree Turmeric interacts with.
Animal research suggests that berberine, a constituent of tree turmeric, can have sedative effects.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Seglentis combines celecoxib (an anti-inflammatory) with tramadol, an opioid-type pain reliever that already works on the brain. The piece to watch here is the tramadol side. Tree turmeric contains berberine, and in animal studies only, berberine showed mild sedative effects. The concern is that stacking it on top of a drug that can already cause drowsiness might add up, leaving you more sleepy, dizzy, or foggy than usual.
I want to be honest about the strength of this: it's theoretical and based on lab and animal data, not solid human research, so don't be alarmed. Still, since tramadol affects the brain, it's worth a quick chat with your pharmacist or doctor before combining them, especially if you drive or feel lightheaded.
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 4Celecoxib, Tramadol also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, can inhibit CYP2D6.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Seglentis combines two medicines, and the tramadol part is the one to watch here. Tramadol relies on an enzyme called CYP2D6 to turn into its stronger pain-relieving form. Berberine, the active piece of tree turmeric, may gently block that enzyme. Because tramadol is partly a prodrug, slowing CYP2D6 can mean less of the active painkiller forms, so you might notice weaker pain relief.
On the flip side, more parent tramadol may linger, which can nudge up side effects like nausea, dizziness, drowsiness, or constipation in some people. Honestly, this is mostly theory backed by lab and early studies, so it may not affect you much. Still, please run it by your pharmacist or doctor before mixing the two.
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
3 of 4Celecoxib, Tramadol also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The combo pill Seglentis pairs celecoxib (an anti-inflammatory) with tramadol (a pain reliever). The celecoxib half leans on a liver enzyme called CYP2C9 to be cleared from your body. Berberine, the active piece of tree turmeric, may slow that enzyme down a bit. So in theory, celecoxib could build up and hang around longer than usual.
If that happens, you might notice more of celecoxib's typical effects: stomach upset, fluid retention, higher blood pressure, or a greater chance of stomach irritation. Keep in mind this is mostly theoretical, based on lower-quality early research, and food-level amounts are unlikely to matter much. Still, before adding a concentrated tree turmeric or berberine supplement, check in with your pharmacist or doctor first.
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
4 of 4Celecoxib, Tramadol also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, moderately inhibits CYP3A4.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Seglentis is a combo pill of celecoxib (an anti-inflammatory) and tramadol (a pain reliever). Berberine, the active part of tree turmeric, can mildly slow down CYP3A4, one of the liver enzymes that helps clear both of these drugs. When that pathway is slowed, the medicine can hang around a bit longer and feel stronger.
For celecoxib, that might mean more stomach upset, fluid retention, or higher blood pressure. For tramadol, it could mean extra drowsiness, dizziness, nausea, or constipation. This is mostly theoretical, and the inhibition is moderate, so it isn't a reason to panic. Still, concentrated berberine supplements are stronger than a sprinkle in food. Before combining them, check with your pharmacist or doctor.
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Tree Turmeric Also Interacts With Other Medications
Tree Turmeric has 2 major, 1,157 moderate known drug interactions in our database — the Celecoxib, Tramadol one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Tree Turmeric
We haven’t checked that one against Tree Turmeric yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Tree Turmeric. Pick one to open its full report.
See Every Supplement That Interacts With Celecoxib, Tramadol
This page covers Tree Turmeric only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Celecoxib, Tramadol page lists 261 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).
By severity: 12 major · 205 moderate · 44 minor.
From our pharmacist’s overview on the Celecoxib, Tramadol page
“Seglentis combines celecoxib and tramadol for pain, and tramadol is why this list deserves real respect. Of the 261 supplements and herbal ingredients on file, 12 rate major, and most of those cluster around two dangers.”
Reviewed by 2 · Jul 18, 2026
Taking Tree Turmeric as Part of a Dietary Supplement Product? Check It for Interactions
We hold 51 real supplement products containing Tree Turmeric, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tree Turmeric. Your product may carry other ingredients that interact with Celecoxib, Tramadol too, on top of Tree Turmeric — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Tree Turmeric and Celecoxib, Tramadol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#997 of 1,452 supplements looked up here in the last 7 days
#1,061 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Tree Turmeric
What is Tree Turmeric?
- Blood sugar support
- High cholesterol
- Digestive complaints
- Skin and eye conditions
- Antimicrobial uses
- Liver support
Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research suggests possible benefits for blood sugar and cholesterol, but high-quality human evidence is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Other Drugs & Tree Turmeric
Browse every other medication we’ve checked against Tree Turmeric — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
1,157 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Guaifenesin ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Nitrazepam ›
- Trimipramine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ketoprofen ›
- Lofepramine ›
Showing 60 of 1,157 moderate interactions — see all 1,157 on the Tree Turmeric page.
No interaction 1,670 drugs checked — show the list
We also checked Tree Turmeric against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Azithromycin ›
- Isotretinoin ›
- Methylene Blue ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Cephalexin ›
- Cyclopentolate ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Levothyroxine Sodium ›
- Ezetimibe ›
- Dexmethylphenidate ›
- Amoxicillin, Clavulanate Potassium ›
- Hexobarbitone ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Factor 7a ›
- Levodopa ›
- Lenvatinib ›
- Mitomycin ›
- Hethylphenidate Hcl ›
- Cefaclor ›
- Azelaic Acid ›
- Phenylephrine ›
- Hydroxychloroquine ›
- Bentoquatam ›
- Vancomycin ›
- Pizotifen ›
- Triptorelin ›
- Dirithromycin ›
- Digoxin ›
- Procainamide ›
- Dextrothyroxine ›
- Tocainide ›
- Rocuronium ›
- Mitomycin C ›
- Digitoxin ›
- Paracetamol ›
- Lomustine ›
- Chenodiol ›
- Gestodene ›
- Desflurane ›
- Salbutamol Sulfate ›
Showing the 60 most looked-up of 1,670 medications checked with no known interaction — see the full Tree Turmeric list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Celecoxib, Tramadol Is Linked to Lower Levels of One Nutrient
Natural Medicines records Celecoxib, Tramadol as a medicine that can lower these. This is not an interaction with Tree Turmeric — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Celecoxib, Tramadol nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Tree Turmeric and Celecoxib, Tramadol Together: Common Questions
Can you take Tree Turmeric with Celecoxib, Tramadol?
Why are there 4 interactions listed for Tree Turmeric and Celecoxib, Tramadol?
How serious is the Tree Turmeric and Celecoxib, Tramadol interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Celecoxib, Tramadol and Tree Turmeric?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.