Drug & supplement interaction

Tronadora + Tipiracil Hydrochloride, Trifluridine

Tipiracil Hydrochloride, Trifluridine brand name: Lonsurf.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tronadora and Tipiracil Hydrochloride, Trifluridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tipiracil Hydrochloride, Trifluridine states a food rule worth keeping to.

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Interaction report

Tronadora and Tipiracil Hydrochloride, Trifluridine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tipiracil Hydrochloride, Trifluridine and Tronadora in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tronadora safety at a glance

Tronadora overall Use caution Limited human safety data; may affect blood sugar, so use with care and medical guidance.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid No reliable safety data while breastfeeding; best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tipiracil Hydrochloride, Trifluridine and Tronadora? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tipiracil Hydrochloride, Trifluridine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tipiracil Hydrochloride, Trifluridine is filed under a single classification — oral drugs. Tronadora has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Tipiracil Hydrochloride, Trifluridine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tronadora Does Interact With Other Medications

Tronadora has 86 moderate known drug interactions in our database — Tipiracil Hydrochloride, Trifluridine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Tipiracil Hydrochloride, Trifluridine)
Taking anything else?

Check Another of Your Medications Against Tronadora

Covers the 2,830 medications we’ve checked against Tronadora. Pick one to open its full report.

What to actually watch for

What Tronadora Itself Has Been Linked To

This is not an interaction — nothing below involves Tipiracil Hydrochloride, Trifluridine. It is the side-effect record for Tronadora on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Tronadora, this list is the first place to look.

  • A skin rash Additional detail

    “There is currently a limited amount of information available about adverse effects of tronadora. Topically, tronadora might cause allergic dermatitis.”

    Tronadora · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 96666. Lakshmi C. Fingertip eczema to pooja flowers: Allergic contact dermatitis to Tabernaemontana divaricata and Tecoma stans. Indian J Dermatol Venereol Leprol. 2015;81(5):514-6. PubMed

    “Topically, tronadora might cause allergic dermatitis. In one case report, an Indian woman that regularly plucked tronadora flowers as part of her morning pooja ritual developed allergic dermatitis.”

    Tronadora · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 96666. Lakshmi C. Fingertip eczema to pooja flowers: Allergic contact dermatitis to Tabernaemontana divaricata and Tecoma stans. Indian J Dermatol Venereol Leprol. 2015;81(5):514-6. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Tronadora — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tipiracil Hydrochloride, Trifluridine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tipiracil Hydrochloride, Trifluridine column appears here.

How to take them

Some Tipiracil Hydrochloride, Trifluridine Products Have a Food Rule — Tronadora Should Not Break It

At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Tronadora on an empty stomach out of habit, keep them separate — and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tipiracil Hydrochloride, Trifluridine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended Dosage : 35 mg/m 2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.

From the Dosage and Administration section of the FDA label we read for Tipiracil Hydrochloride, Trifluridine — where that label names a specific product, the instruction is that product's. See the Tipiracil Hydrochloride, Trifluridine drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tipiracil Hydrochloride, Trifluridine

This page covers Tronadora only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tipiracil Hydrochloride, Trifluridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Tipiracil Hydrochloride, Trifluridine interaction page

How much people look this up

Where Tronadora and Tipiracil Hydrochloride, Trifluridine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tronadora
Steady interest

#753 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tipiracil Hydrochloride, Trifluridine
Top 25%

#585 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tronadora reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tronadora and Tipiracil Hydrochloride, Trifluridine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tronadora

What is Tronadora?

  • Blood sugar control / diabetes
  • Digestive complaints
  • Mild fever
  • Yeast or fungal concerns
  • Traditional 'tonic' use

Tronadora (Tecoma stans) is a flowering shrub used in Mexican and Latin American folk medicine, most often as a tea for diabetes and digestive complaints. Human evidence is very limited, so it should not replace proven treatments. Because it may affect blood sugar and its safety is not well studied, talk to your pharmacist or doctor before using it—and avoid it during pregnancy and breastfeeding.

Tecoma stans · Bignoniaceae · Leaves, flowers, and sometimes roots and bark · Tea (infusion), dried herb, capsules, liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Tronadora is a good idea for someone in your situation. Here is what our Tronadora record says about it on its own.

Tronadora: dosing

There is no established, standardized dose for Tronadora. Traditional use is often as a tea made from the dried leaves or flowers, but the amount of active compounds can vary a lot between products and batches.If you choose to use it, follow the directions on the product label and start low.

From our Tronadora monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tronadora monograph & all interactions
Medication

About Trifluridine and Tipiracil

What Is Trifluridine and Tipiracil Used For?

Brand name: Lonsurf

Lonsurf (trifluridine and tipiracil) is used to treat adults with metastatic colorectal cancer — either alone or combined with bevacizumab — after prior treatment with several other chemotherapy regimens and targeted therapies.

Lonsurf is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma (cancer of the stomach or where the stomach meets the esophagus) who have already received at least two prior chemotherapy regimens.

See full Trifluridine and Tipiracil drug information
Keep checking

Other Drugs & Tronadora

Browse every other medication we’ve checked against Tronadora — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Tronadora page.

No interaction 2,743 drugs checked — show the list

We also checked Tronadora against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Tronadora list.

See the full Tronadora interactions page
See every supplement checked against Tipiracil Hydrochloride, Trifluridine, ranked by severity
Evidence & sources

Tronadora References

The 7 references that drive our Tronadora monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Costantino L, Raimondi L, Pirisino R, et al. Isolation and pharmacological activities of the Tecoma stans alkaloids. Farmaco 2003;58:781-5. PubMed
  2. Meckes-Lozoya M, Ibanez-Camacho R. Hepatic glycogenolysis produced by intraperitoneal administration of total extract of Tecoma stans in rats. Arch Invest Med (Mex) 1985;16:387-9.
  3. Roman-Ramos R, Flores-Saenz JL, Partida-Hernandez G, et al. Experimental study of the hypoglycemic effect of some antidiabetic plants. Arch Invest Med (Mex) 1991;22:87-93.
  4. Lakshmi C. Fingertip eczema to pooja flowers: Allergic contact dermatitis to Tabernaemontana divaricata and Tecoma stans. Indian J Dermatol Venereol Leprol. 2015;81(5):514-6. PubMed
  5. Pascoe-González S, Ramos-Zavala MG, Buenrostro Ahued MA, et al. Administration of herbarium mixture (Guazuma ulmifolia/Tecoma stans) on metabolic profile in type 2 diabetes mellitus patients: A randomized, double-blind, placebo-controlled trial. J Med Foo
  6. Gupta A, Behl T, Sehgal A, et al. Elucidating the neuroprotective effect of Tecoma stans leaf extract in STZ-induced diabetic neuropathy. Evid Based Complement Alternat Med 2022;2022:3833392. PubMed
  7. Morales-Ferra DL, Zavala-Sánchez MÁ, Jiménez-Ferrer E, González-Cortazar M, Zamilpa A. Effect of Tecoma stans (L.) Juss. ex Kunth in a murine model of metabolic syndrome. Plants (Basel) 2022;11(14):1794. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tronadora and Tipiracil Hydrochloride, Trifluridine Together: Common Questions

Is it safe to take Tronadora with Tipiracil Hydrochloride, Trifluridine?
We do not list a known interaction between Tronadora and Tipiracil Hydrochloride, Trifluridine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Tronadora and Tipiracil Hydrochloride, Trifluridine at the same time of day?
At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Tronadora on an empty stomach out of habit, keep them separate and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Tipiracil Hydrochloride, Trifluridine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Tronadora and Tipiracil Hydrochloride, Trifluridine combination checked?
Interactions in our licensed database are recorded against drug classes. Tipiracil Hydrochloride, Trifluridine is filed under 1 classification, and Tronadora has documented interactions with 1 drug class — none of Tipiracil Hydrochloride, Trifluridine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tronadora interact with any other medications?
Yes. Tronadora has 86 documented drug interactions in our database — Tipiracil Hydrochloride, Trifluridine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tipiracil Hydrochloride, Trifluridine interact with any supplements?
Yes. Tipiracil Hydrochloride, Trifluridine has documented interactions with 17 supplements in our database — Tronadora is not one of them. The Tipiracil Hydrochloride, Trifluridine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tronadora monograph Uses, safety profile, and every drug interaction in one place Trifluridine and Tipiracil drug information The full plain-English guide to this medication Tipiracil Hydrochloride, Trifluridine supplement interactions Every supplement checked against Tipiracil Hydrochloride, Trifluridine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tipiracil Hydrochloride, Trifluridine and Tronadora?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.