Turkey Tail Mushroom + Acetaminophen, Codeine
Acetaminophen, Codeine brand names: Tylenol w/ Codeine, Tylenol No.3.
We found no known interaction between Turkey Tail Mushroom and Acetaminophen, Codeine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Turkey Tail Mushroom and Acetaminophen, Codeine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Acetaminophen, Codeine and Turkey Tail Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Turkey Tail Mushroom safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Acetaminophen, Codeine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Acetaminophen, Codeine is filed under 13 classifications — including codeine, cytochrome p450 2e1 (cyp2e1) substrates, narcotic drugs. Turkey Tail Mushroom has documented interactions with 4 drug classes — the most serious being antidiabetes drugs (moderate), cyclophosphamide (moderate) and tamoxifen (nolvadex) (moderate) — and none of Acetaminophen, Codeine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Turkey Tail Mushroom Does Interact With Other Medications
Turkey Tail Mushroom has 88 moderate, 99 minor known drug interactions in our database — Acetaminophen, Codeine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Turkey Tail Mushroom
We haven’t checked that one against Turkey Tail Mushroom yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Turkey Tail Mushroom. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Codeine
This page covers Turkey Tail Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Codeine page lists 240 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).
By severity: 9 major · 191 moderate · 40 minor.
From our pharmacist’s overview on the Acetaminophen, Codeine page
“People usually take Tylenol No. 3 (acetaminophen with codeine) for short-term pain, often while still drinking wine with dinner or reaching for an herbal sleep aid.”
Reviewed by 2 · Jul 18, 2026
Where Turkey Tail Mushroom and Acetaminophen, Codeine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,368 of 1,452 supplements looked up here in the last 7 days
#57 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Turkey Tail Mushroom reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Turkey Tail Mushroom and Acetaminophen, Codeine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Turkey Tail Mushroom
What is Turkey Tail Mushroom?
- Immune support
- Used alongside cancer care
- Gut and digestive health
- General wellness and energy
- Antioxidant support
Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studied as add-on treatments alongside conventional cancer therapy in Asia, but evidence for everyday supplement use is limited. It is generally well tolerated, but talk to your pharmacist or doctor before using it, especially if you have a health condition or take other medicines.
Trametes versicolor · Polyporaceae · Fruiting body and mycelium (and extracts such as PSK and PSP) · Capsules, tablets, powders, teas, tinctures, standardized extracts (PSK/PSP)
An interaction check asks whether these two react with each other — it does not ask whether Turkey Tail Mushroom is a good idea for someone in your situation. Here is what our Turkey Tail Mushroom record says about it on its own.
Turkey Tail Mushroom: dosing
There is no official standardized dose of turkey tail for general use. Doses vary widely depending on whether you are using the whole mushroom powder, a tea, or a concentrated extract such as PSK or PSP.Because products differ so much, the best approach is to follow the directions on the product label and not exceed them. A pharmacist or doctor can help you decide whether turkey tail is appropriate for you and review your other medicines and conditions first.
From our Turkey Tail Mushroom monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Turkey Tail Mushroom
Browse every other medication we’ve checked against Turkey Tail Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
88 interactions
- Insulin (rdna) ›
- Glyburide ›
- Insulin (pork) ›
- Insulin (human) ›
- Acarbose ›
- Insulin Glargine ›
- Semaglutide ›
- Chlorpropamide ›
- Cyclophosphamide ›
- Exenatide ›
- Glipizide ›
- Glucagon ›
- Insulin Lispro ›
- Metformin ›
- Repaglinide ›
- Sitagliptin ›
- Tamoxifen Citrate ›
- Tirzepatide ›
- Acetohexamide ›
- Albiglutide ›
- Alogliptin ›
- Canagliflozin ›
- Dapagliflozin ›
- Dasiglucagon Hydrochloride ›
- Dulaglutide ›
- Empagliflozin ›
- Ertugliflozin ›
- Exenatide Synthetic ›
- Gliclazide ›
- Glimepiride ›
- Glucose ›
- Inhaled Insulin ›
- Insulin ›
- Insulin (bovine) ›
- Insulin Aspart ›
- Insulin Degludec ›
- Insulin Determir ›
- Insulin Glargine (rdna) ›
- Insulin Glargine Recombinant ›
- Insulin Glulisine (rdna) ›
- Insulin Lispro Recombinant ›
- Insulin Lispro-aabc ›
- Linagliptin ›
- Liraglutide ›
- Liraglutide Recombinant ›
- Lixisenatide ›
- Metformin Hydrochloride ›
- Metformin Xr ›
- Miglitol ›
- Muraglitazar ›
- Nateglinide ›
- Pioglitazone ›
- Pramlintide ›
- Rosiglitazone Maleate ›
- Saxagliptin ›
- Sotagliflozin ›
- Tobutamide ›
- Tolazamide ›
- Tolbutamide ›
- Troglitazone ›
Showing 60 of 88 moderate interactions — see all 88 on the Turkey Tail Mushroom page.
99 interactions
- Diclofenac Sodium ›
- Ibuprofen ›
- Naproxen ›
- Flurbiprofen ›
- Phenytoin ›
- Diclofenac Potassium ›
- Formoterol ›
- Indomethacin ›
- Trimipramine ›
- Diazepam ›
- Meloxicam ›
- Omeprazole ›
- Warfarin Sodium ›
- Carvedilol ›
- Celecoxib ›
- Clomipramine ›
- Diclofenac Epolamine ›
- Dronabinol ›
- Fluoxetine ›
- Fluvastatin ›
- Imipramine ›
- Irbesartan ›
- Lacosamide ›
- Piroxicam ›
- Pitavastatin ›
- Tapentadol ›
- Torsemide ›
- Valsartan ›
- Zileuton ›
- Abrocitinib ›
- Agomelatine ›
- Amitriptyline ›
- Azilsartan ›
- Bosentan ›
- Clopidogrel ›
- Diclofenac ›
- Effient ›
- Enasidenib ›
- Erdafitinib ›
- Etrasimod ›
- Etravirine ›
- Fomoterol ›
- Fosphenytoin ›
- Fosphenytoin Sodium ›
- Ibuprofen Lysine ›
- Lesinurad ›
- Lonafarnib ›
- Losartan Potassium ›
- Lumiracoxib ›
- Mefenamic Acid ›
- Mephenytoin ›
- Montelukast Sodium ›
- Naproxen Sodium ›
- Perampanel ›
- Rabeprazole ›
- Ramelteon ›
- Sildenafil ›
- Sildenafil Citrate ›
- Siponimod ›
- Sulfamethoxazole ›
Showing 60 of 99 minor interactions — see all 99 on the Turkey Tail Mushroom page.
No interaction 2,642 drugs checked — show the list
We also checked Turkey Tail Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Doxycycline ›
- Lamotrigine ›
- Methotrexate ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Atorvastatin Calcium ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Daptomycin ›
Showing the 60 most looked-up of 2,642 medications checked with no known interaction — see the full Turkey Tail Mushroom list.
Turkey Tail Mushroom References
The 15 references that drive our Turkey Tail Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;343:1122-6. PubMed
- Mitomi T, Tsuchiya S, Iijima N, et al. Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanag DOI
- Torisu M, Hayashi Y, Ishimitsu T, et al. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 1990;31:261-8. PubMed
- Tsujitani, S., Kakeji, Y., Orita, H., Watanabe, A., Kohnoe, S., Baba, H., Anai, H., Maehara, Y., and Sugimachi, K. Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer. Anticancer Res 199
- Kojima, J., Kamata, T., and Monna, T. [Evaluation of immunochemotherapy in patients with primary liver cancer. Osaka Research Society for Liver, Gallbladder and Pancreas]. Gan To Kagaku Ryoho 1987;14(1):179-187.
- Fukuo, Y., Terashi, A., Hayashi, Y., Yano, Y., and Atarashi, J. [A clinical trial of cis-platinum (II) in combination with PSK and FT-207 in advanced stomach cancer]. Gan To Kagaku Ryoho 1985;12(4):960-965.
- Imaizumi, M., Kondo, T., Kamei, H., and Ichihashi, H. [Cooperative studies on surgical adjuvant immunochemotherapy for prevention of postoperative recurrence of gastric cancer]. Gan To Kagaku Ryoho 1984;11(1):60-68.
- Yeung JH and Or PM. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. Phytomedicine 2011;18(13):1170-5. PubMed
- Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov 2012;6(1):78-87. PubMed
- Chan SL, Yeung JH. Effects of polysaccharide peptide (PSP) from Coriolus versicolor on the pharmacokinetics of cyclophosphamide in the rat and cytotoxicity in HepG2 cells. Food Chem Toxicol 2006;44:689-94. PubMed
- Serrano L, López AC, González SP, et al. Efficacy of a Coriolus versicolor-based vaginal gel in women with human papillomavirus-dependent cervical lesions: The PALOMA study. J Low Genit Tract Dis 2021;25(2):130-136. PubMed
- Meng F, Lin Y, Hu L, Feng W, Su P, Wu L. The therapeutic effect of Coriolus versicolor fruiting body on STZ-induced ICR diabetic mice. J Healthc Eng 2022;2022:7282453. PubMed
- Razmovski-Naumovski V, Kimble B, Laurenti D, Nammi S, Norimoto H, Chan K. Polysaccharide peptide extract from Coriolus versicolor increased T(max) of tamoxifen and maintained biochemical serum parameters, with no change in the metabolism of tamoxifen in t
- Cortés Bordoy J, de Santiago García J, Agenjo González M, et al. Effect of a multi-ingredient Coriolus-versicolor-based vaginal gel in women with HPV-dependent cervical lesions: The papilobs real-life prospective study. Cancers (Basel) 2023;15(15):3863. PubMed
- Nikolic M, Lazarevic N, Novakovic J, et al. Characterization, in vitro biological activity and in vivo cardioprotective properties of Trametes versicolor (L.:Fr.) quél. heteropolysaccharides in a rat model of metabolic syndrome. Pharmaceuticals (Basel) 20 PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Acetaminophen, Codeine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Codeine as a medicine that can lower these. This is not an interaction with Turkey Tail Mushroom — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Acetaminophen, Codeine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Turkey Tail Mushroom and Acetaminophen, Codeine Together: Common Questions
Is it safe to take Turkey Tail Mushroom with Acetaminophen, Codeine?
Do Turkey Tail Mushroom and Acetaminophen, Codeine have any of the same side effects?
How was the Turkey Tail Mushroom and Acetaminophen, Codeine combination checked?
Does Turkey Tail Mushroom interact with any other medications?
Does Acetaminophen, Codeine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.