Drug & supplement interaction

Vitamin B6 + Phenobarbital, Sodium Nitrate

Phenobarbital, Sodium Nitrate brand name: Soniphen.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Vitamin B6 has a moderate interaction with Phenobarbital, Sodium Nitrate. High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Vitamin B6 and Phenobarbital, Sodium Nitrate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

PHENOBARBITAL (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for the phenobarbital part of this medicine: some early reports suggest that high-dose vitamin B6 (around 200 mg a day) may speed up how your body clears phenobarbital. That can pull your blood levels down, and since phenobarbital controls seizures and helps with sedation, lower levels could mean it works less well. For someone relying on it to prevent seizures, that's worth taking seriously.

The good news: this is based on weak, anecdotal evidence, and it's the big supplement doses that raise concern. The B6 you get from food, or a normal multivitamin, isn't expected to cause trouble. Please don't change anything on your own. Just check with your pharmacist or doctor before adding a high-dose B6 supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Vitamin B6 Also Interacts With Other Medications

Vitamin B6 has 204 moderate, 5 minor known drug interactions in our database — the Phenobarbital, Sodium Nitrate one above is one of them. If you take anything else, check it against the full list below.

Moderate 204 Minor 5 No known interaction 2,621 (incl. Phenobarbital, Sodium Nitrate)
Taking anything else?

Check Another of Your Medications Against Vitamin B6

Covers the 2,830 medications we’ve checked against Vitamin B6. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Phenobarbital, Sodium Nitrate

This page covers Vitamin B6 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenobarbital, Sodium Nitrate page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 115 moderate · 18 minor.

From our pharmacist’s overview on the Phenobarbital, Sodium Nitrate page

“Phenobarbital with sodium nitrate (Soniphen) is a barbiturate, a heavy sedative used mainly for seizures, and its supplement list calls for real care before you add anything to it. Of the 141 ingredients on file, 78 pile extra sedation onto a drug that already slows breathing and reflexes, and six of the eight major-rated entries sit i…”

Reviewed by 2 · Jul 18, 2026

Open the Phenobarbital, Sodium Nitrate interaction page

One more smart check

Taking Vitamin B6 as Part of a Dietary Supplement Product? Check It for Interactions

We hold 24,838 real supplement products containing Vitamin B6, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vitamin B6. Your product may carry other ingredients that interact with Phenobarbital, Sodium Nitrate too, on top of Vitamin B6 — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vitamin B6 and Phenobarbital, Sodium Nitrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vitamin B6
Top 10

#3 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenobarbital, Sodium Nitrate
Steady interest

#1,817 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Vitamin B6

What is Vitamin B6?

  • Morning sickness in pregnancy
  • Premenstrual syndrome (PMS)
  • Preventing or treating B6 deficiency
  • Nerve health and metabolism support
  • Nausea

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-related nausea and may help some people with PMS, but taking very high doses for long periods can cause nerve damage. Get most of your B6 from food, and check with a pharmacist or doctor before taking high-dose supplements.

Read the full Vitamin B6 monograph & all interactions
Keep checking

Other Drugs & Vitamin B6

Browse every other medication we’ve checked against Vitamin B6 — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
204Moderate
5Minor
2,620No known interaction
204 Moderate 5 Minor 2,620 No interaction
Moderate

204 interactions

Showing 60 of 204 moderate interactions — see all 204 on the Vitamin B6 page.

Minor

5 interactions

No interaction 2,620 drugs checked — show the list

We also checked Vitamin B6 against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,620 medications checked with no known interaction — see the full Vitamin B6 list.

See the full Vitamin B6 interactions page
See every supplement checked against Phenobarbital, Sodium Nitrate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Vitamin B6 monograph › Uses, safety, and every drug interaction in one place Phenobarbital, Sodium Nitrate supplement interactions › Every supplement checked against Phenobarbital, Sodium Nitrate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Vitamin B6 and Phenobarbital, Sodium Nitrate Together: Common Questions

Can you take Vitamin B6 with Phenobarbital, Sodium Nitrate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Vitamin B6 and Phenobarbital, Sodium Nitrate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Phenobarbital, Sodium Nitrate and Vitamin B6?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.