Medication interaction hub

What Supplements Interact with Phenobarbital, Sodium Nitrate?

Phenobarbital, Sodium Nitrate brand name: Soniphen. Every interaction below applies to the brands too.

141 Interactions 8 Major 115 Moderate 18 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Phenobarbital, Sodium Nitrate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Phenobarbital, Sodium Nitrate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Phenobarbital with sodium nitrate (Soniphen) is a barbiturate, a heavy sedative used mainly for seizures, and its supplement list calls for real care before you add anything to it. Of the 141 ingredients on file, 78 pile extra sedation onto a drug that already slows breathing and reflexes, and six of the eight major-rated entries sit in that group, alcohol and kava among them. St. John's wort is the other big one, speeding up how your body clears phenobarbital until it may no longer hold seizures in check.

A smaller cluster of liver enzyme inducers weakens the drug in the same quiet way, without any warning you can feel. Others, activated charcoal among them, cut the absorption of pills taken by mouth, so space those well apart from your dose. The remaining 115 moderate and 18 minor entries are mostly manageable, but read the eight major ones first, and skip alcohol entirely on this medication.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 115 Minor 18 No known interaction 1,311

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Phenobarbital, Sodium Nitrate: Top Interactions at a Glance

The Phenobarbital, Sodium Nitrate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 141 interacting ingredients — plus 1,311 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Phenobarbital, Sodium Nitrate Combinations Today

The Phenobarbital, Sodium Nitrate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Calamus + Phenobarbital, Sodium Nitratei

Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.

Read the full interaction Moderate Likelihood Possible Hemp Agrimony + Phenobarbital, Sodium Nitratei

Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4).

Read the full interaction Moderate Likelihood Possible Elecampane + Phenobarbital, Sodium Nitratei

Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Read the full interaction Moderate Likelihood Possible Cannabinol (cbn) + Phenobarbital, Sodium Nitratei

Theoretically, cannabinol might increase the levels and clinical effects of CYP2B6 substrates.

Read the full interaction Moderate Likelihood Possible Guarumo + Phenobarbital, Sodium Nitratei

In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle relaxant activity.

Read the full interaction Major Likelihood Likely Beer + Phenobarbital, Sodium Nitratei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Phenobarbital, Sodium Nitrate

All 1,452 ingredients in our database, ranked by severity — 141 with a Phenobarbital, Sodium Nitrate interaction on file and 1,311 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Phenobarbital, Sodium Nitrate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calamus with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.

Full Calamus + Phenobarbital, Sodium Nitrate answer

Can you take Hemp Agrimony with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4).

Full Hemp Agrimony + Phenobarbital, Sodium Nitrate answer

Can you take Elecampane with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Phenobarbital, Sodium Nitrate answer

Can you take Cannabinol (cbn) with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabinol might increase the levels and clinical effects of CYP2B6 substrates.

Full Cannabinol (cbn) + Phenobarbital, Sodium Nitrate answer

Can you take Guarumo with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle...

Full Guarumo + Phenobarbital, Sodium Nitrate answer

Can you take Coriander with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.

Full Coriander + Phenobarbital, Sodium Nitrate answer

Can you take Corn Poppy with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.

Full Corn Poppy + Phenobarbital, Sodium Nitrate answer

Can you take Corydalis Yanhusuo with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Full Corydalis Yanhusuo + Phenobarbital, Sodium Nitrate answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Phenobarbital, Sodium Nitrate answer

Can you take Dusty Miller with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in dusty miller.

Full Dusty Miller + Phenobarbital, Sodium Nitrate answer

Can you take European Barberry with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Phenobarbital, Sodium Nitrate answer

Can you take Evodia with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers might decrease the levels and clinical effects of evodia.

Full Evodia + Phenobarbital, Sodium Nitrate answer

Can you take Fo-ti with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2B6.

Full Fo-ti + Phenobarbital, Sodium Nitrate answer

Can you take Galphimia Glauca with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.

Full Galphimia Glauca + Phenobarbital, Sodium Nitrate answer

Can you take Gamma Butyrolactone (gbl) with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Full Gamma Butyrolactone (gbl) + Phenobarbital, Sodium Nitrate answer

Can you take German Chamomile with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Phenobarbital, Sodium Nitrate answer

Can you take Golden Ragwort with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in golden ragwor...

Full Golden Ragwort + Phenobarbital, Sodium Nitrate answer

Can you take Goldenseal with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the sedative effects of CNS depressants.

Full Goldenseal + Phenobarbital, Sodium Nitrate answer

Can you take Gotu Kola with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Phenobarbital, Sodium Nitrate answer

Can you take Gravel Root with Phenobarbital, Sodium Nitrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Phenobarbital, Sodium Nitrate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Phenobarbital, Sodium Nitrate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Phenobarbital, Sodium Nitrate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Phenobarbital, Sodium Nitrate sits in 9 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Phenobarbital, Sodium Nitrate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Phenobarbital, Sodium Nitrate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Phenobarbital, Sodium Nitrate through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Phenobarbital, Sodium Nitrate through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Phenobarbital, Sodium Nitrate through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Phenobarbital, Sodium Nitrate through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Phenobarbital, Sodium Nitrate through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Phenobarbital, Sodium Nitrate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Phenobarbital, Sodium Nitrate through this category.

Related: does Phenobarbital, Sodium Nitrate deplete any nutrients?

Phenobarbital, Sodium Nitrate has 10 reported nutrient associations in the research literature — see the Phenobarbital, Sodium Nitrate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Phenobarbital, Sodium Nitrate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Phenobarbital, Sodium Nitrate.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Products that contain Phenobarbital, Sodium Nitrate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Phenobarbital, Sodium Nitrate.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Phenobarbital, Sodium Nitrate & Supplements: Common Questions

What supplements interact with Phenobarbital, Sodium Nitrate?
Our database currently documents 141 ingredients with a known Phenobarbital, Sodium Nitrate interaction (8 major, 115 moderate, 18 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 141. The highest-ranked right now: Beer, St. John's Wort, Wine.
Which Phenobarbital, Sodium Nitrate supplement interactions are the most serious?
Focus on the major group: Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Phenobarbital, Sodium Nitrate?
Plenty of supplements coexist fine with Phenobarbital, Sodium Nitrate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Soniphen have the same supplement interactions as Phenobarbital, Sodium Nitrate?
Yes — Soniphen all contain Phenobarbital, Sodium Nitrate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Phenobarbital, Sodium Nitrate deplete any vitamins or nutrients?
It might — Phenobarbital, Sodium Nitrate has 10 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Phenobarbital, Sodium Nitrate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Phenobarbital, Sodium Nitrate and my other medications?
This page covers Phenobarbital, Sodium Nitrate against supplements and herbal ingredients. Checking Phenobarbital, Sodium Nitrate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.