Medication interaction hub

What Supplements Interact with Estrone?

Estrone brand name: Ortho-Est. Every interaction below applies to the brands too.

77 Interactions 2 Major 61 Moderate 14 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Estrone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Estrone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hormone therapy lives or dies by a steady blood level, and estrone (Ortho-Est), an estrogen taken mostly for menopause symptoms, is no exception, so this list calls for genuine care. The two major-rated entries among the 77 both change how much estrone your body actually gets: grapefruit raises estrogen levels by blocking the enzyme that clears the hormone, while activated charcoal pulls the drug out of circulation and lowers what you absorb.

The other 61 moderate and 14 minor entries follow two patterns. Most act on estrogen itself, either boosting its levels and side effects or competing at its receptors and blunting the therapy. Seventeen can bind or slow almost any pill taken by mouth, so space those well apart from your dose. One quirk to remember is that estrone slows caffeine clearance, so your usual coffee may hit harder while you take it.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 61 Minor 14 No known interaction 1,375

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Estrone: Top Interactions at a Glance

The Estrone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 77 interacting ingredients — plus 1,375 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Estrone Combinations Today

The Estrone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Hemp + Estronei

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Minor Likelihood Possible Dhea + Estronei

Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.

Read the full interaction Moderate Likelihood Probable Red Clover + Estronei

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Read the full interaction Moderate Likelihood Probable Vitex Agnus-castus + Estronei

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.

Read the full interaction Minor Likelihood Unlikely Deer Velvet + Estronei

Theoretically, deer velvet might increase the effects and side effects of estrogens.

Read the full interaction Moderate Likelihood Possible Aletris + Estronei

Aletris might have estrogenic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Estrone

All 1,452 ingredients in our database, ranked by severity — 77 with a Estrone interaction on file and 1,375 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Estrone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hemp with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Estrone answer

Can you take Dhea with Estrone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.

Full Dhea + Estrone answer

Can you take Red Clover with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Full Red Clover + Estrone answer

Can you take Vitex Agnus-castus with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with the activity of estrogens.

Full Vitex Agnus-castus + Estrone answer

Can you take Deer Velvet with Estrone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deer velvet might increase the effects and side effects of estrogens.

Full Deer Velvet + Estrone answer

Can you take Diindolylmethane with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diindolylmethane might increase or decrease the effects of estrogens.

Full Diindolylmethane + Estrone answer

Can you take Dong Quai with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dong quai may reduce the effects of estrogens.

Full Dong Quai + Estrone answer

Can you take Equol with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, equol might increase the levels and clinical effects of estrogens.

Full Equol + Estrone answer

Can you take Fennel with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Full Fennel + Estrone answer

Can you take Flaxseed with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking flaxseed might decrease the effects of estrogens.

Full Flaxseed + Estrone answer

Can you take German Chamomile with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.

Full German Chamomile + Estrone answer

Can you take Guar Gum with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Estrone answer

Can you take Guggul with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.

Full Guggul + Estrone answer

Can you take Gum Arabic with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Estrone answer

Can you take Hops with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen rec...

Full Hops + Estrone answer

Can you take Horny Goat Weed with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.

Full Horny Goat Weed + Estrone answer

Can you take Hu Zhang with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.

Full Hu Zhang + Estrone answer

Can you take Indole-3-carbinol with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Indole-3-carbinol might interfere with the effects of estrogen therapy.

Full Indole-3-carbinol + Estrone answer

Can you take Kudzu with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kudzu might alter the effects of estrogen therapy.

Full Kudzu + Estrone answer

Can you take Licorice with Estrone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease the effects of estrogen therapy.

Full Licorice + Estrone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Estrone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Estrone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Estrone sits in 2 interaction categories. Open any one to see what the group means:

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Estrone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Estrone through this category.

Related: does Estrone deplete any nutrients?

Estrone has 5 reported nutrient associations in the research literature — see the Estrone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Estrone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Estrone.

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Pharmacist Counseling Corner

Estrone & Supplements: Common Questions

What supplements interact with Estrone?
More than you might expect — 77 in total, though they are far from equal: 2 are rated major, 61 moderate, and 14 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Grapefruit, Black Tea.
Which Estrone supplement interactions are the most serious?
The 2 major-rated combinations — led by Activated Charcoal and Grapefruit — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Estrone?
Usually yes — most people on Estrone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Ortho-Est have the same supplement interactions as Estrone?
Yes — Ortho-Est all contain Estrone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Estrone deplete any vitamins or nutrients?
It might — Estrone has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Estrone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Estrone and my other medications?
This page covers Estrone against supplements and herbal ingredients. Checking Estrone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.