Medication interaction hub

What Supplements Interact with Estropipate?

Estropipate brand names: Ogen, Ortho EST. Every interaction below applies to the brands too.

77 Interactions 2 Major 61 Moderate 14 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Estropipate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Estropipate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Estropipate (Ogen, Ortho EST) is an estrogen taken for menopause symptoms, and the women who use it are drawn to hormone-touted herbs, which fill this list of 77 ingredients, so it deserves genuine care. Grapefruit is one of two major-rated entries; it blocks the enzyme that clears estrogen, so levels and side effects can climb. Most of the 61 moderate entries either act like weak estrogens, competing with the drug and possibly blunting it, or involve caffeine, which estrogen clears more slowly, meaning your usual cup hits harder.

The other major is activated charcoal, which can soak up the tablet and cut what your body absorbs; bulky fibers act similarly, so space them well apart from your dose. The 14 minor entries carry less weight. Understand those two majors first, then ask your pharmacist before adding any hormone-acting herb, since a quietly weakened therapy can go unnoticed for months.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 61 Minor 14 No known interaction 1,375

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Estropipate: Top Interactions at a Glance

The Estropipate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 77 interacting ingredients — plus 1,375 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Estropipate Combinations Today

The Estropipate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Dhea + Estropipatei

Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.

Read the full interaction Moderate Likelihood Possible Hemp + Estropipatei

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Moderate Likelihood Probable Caffeine + Estropipatei

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Wild Yam + Estropipatei

Theoretically, wild yam might increase or decrease the effects of estrogen.

Read the full interaction Moderate Likelihood Possible Pleurisy Root + Estropipatei

Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.

Read the full interaction Moderate Likelihood Probable Coffee + Estropipatei

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction
The complete list

Every Supplement Checked Against Estropipate

All 1,452 ingredients in our database, ranked by severity — 77 with a Estropipate interaction on file and 1,375 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Estropipate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Dhea with Estropipate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.

Full Dhea + Estropipate answer

Can you take Hemp with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Estropipate answer

Can you take Caffeine with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Caffeine + Estropipate answer

Can you take Wild Yam with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wild yam might increase or decrease the effects of estrogen.

Full Wild Yam + Estropipate answer

Can you take Pleurisy Root with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.

Full Pleurisy Root + Estropipate answer

Can you take Activated Charcoal with Estropipate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Estropipate answer

Can you take Grapefruit with Estropipate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase blood levels of estrogens, potentially increasing the effects and adverse effects of estrogens.

Full Grapefruit + Estropipate answer

Can you take Black Tea with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Black Tea + Estropipate answer

Can you take Cocoa with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Cocoa + Estropipate answer

Can you take Coffee with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Coffee + Estropipate answer

Can you take Coffee Charcoal with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Estropipate answer

Can you take Cola Nut with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Estropipate answer

Can you take European Mandrake with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Estropipate answer

Can you take Fo-ti with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking large amounts of fo-ti might interfere with hormone replacement therapy through competition for estrogen receptors.

Full Fo-ti + Estropipate answer

Can you take Glucomannan with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Estropipate answer

Can you take Green Coffee with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Green Coffee + Estropipate answer

Can you take Green Tea with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Green Tea + Estropipate answer

Can you take Guarana with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Guarana + Estropipate answer

Can you take Ilex Guayusa with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Ilex Guayusa + Estropipate answer

Can you take Oolong Tea with Estropipate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine in oolong tea.

Full Oolong Tea + Estropipate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Estropipate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Estropipate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Estropipate sits in 2 interaction categories. Open any one to see what the group means:

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Estropipate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Estropipate through this category.

About Estropipate

Estrogen is a hormone used to treat hot flashes and vaginal symptoms during menopause, and to prevent bone loss in menopausal women.

Generic name: Estropipate  ·  Brand names: Ogen, Ortho EST.

See the full Estrogen drug information

Related: does Estropipate deplete any nutrients?

Estropipate has 10 reported nutrient associations in the research literature — see the Estropipate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Estropipate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Estropipate.

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Pharmacist Counseling Corner

Estropipate & Supplements: Common Questions

What supplements interact with Estropipate?
Our database currently documents 77 ingredients with a known Estropipate interaction (2 major, 61 moderate, 14 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 77. The highest-ranked right now: Activated Charcoal, Grapefruit, Black Tea.
Which Estropipate supplement interactions are the most serious?
The 2 major-rated combinations — led by Activated Charcoal and Grapefruit — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Estropipate?
Plenty of supplements coexist fine with Estropipate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Ogen have the same supplement interactions as Estropipate?
Yes — Ogen, Ortho EST all contain Estropipate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Estropipate deplete any vitamins or nutrients?
It might — Estropipate has 10 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Estropipate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Estropipate and my other medications?
This page covers Estropipate against supplements and herbal ingredients. Checking Estropipate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Estrogen drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.