Drug & supplement interaction

Ipriflavone + Estropipate

Estropipate brand names: Ogen, Ortho EST.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ipriflavone and Estropipate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ipriflavone and Estropipate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Estropipate and Ipriflavone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ipriflavone safety at a glance

Ipriflavone overall Use caution May lower white blood cell counts and has limited long-term safety data.
Pregnancy Avoid Not enough safety data and possible estrogen-like effects; avoid use.
Breastfeeding Avoid No reliable safety information during breastfeeding; best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Estropipate and Ipriflavone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Estropipate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Estropipate is filed under 2 classifications — estrogens, oral drugs. Ipriflavone has documented interactions with 4 drug classes — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (moderate), cytochrome p450 2c9 (cyp2c9) substrates (moderate) and immunosuppressants (moderate) — and none of Estropipate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ipriflavone Does Interact With Other Medications

Ipriflavone has 391 moderate known drug interactions in our database — Estropipate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 391 No known interaction 2,439 (incl. Estropipate)
Taking anything else?

Check Another of Your Medications Against Ipriflavone

Covers the 2,830 medications we’ve checked against Ipriflavone. Pick one to open its full report.

What to actually watch for

What Ipriflavone Itself Has Been Linked To

This is not an interaction — nothing below involves Estropipate. It is the side-effect record for Ipriflavone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ipriflavone, this list is the first place to look.

  • Dizziness Additional detail

    “Orally, ipriflavone is generally well-tolerated. However, some patients taking ipriflavone can experience epigastric pain, diarrhea, and dizziness. There is some concern that ipriflavone can cause lymphocytopenia when used for at least 6 months.”

    Ipriflavone · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 432. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
    2. 104208. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed
    3. 1196. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  • Diarrhea Additional detail

    “Orally, ipriflavone can cause epigastric pain and diarrhea in some people.”

    Ipriflavone · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 432. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
    2. 104208. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Ipriflavone — expand a row for the licensed statement it rests on. We haven’t matched Estropipate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Estropipate.

Overlapping uses

What Estropipate Is Prescribed For, and What Ipriflavone Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Estropipate is a prescription medicine with approved uses on its FDA label. Ipriflavone is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Estropipate is prescribed for: Based on the available product information, this Estrogen product is intended for external use on the skin — specifically the face, neck, or body. It is applied as part of a daily skincare routine. For any specific medical concerns, the label recommends consulting a healthcare provider before use.

Ipriflavone has been studied for:

  • Osteoporosis Natural Medicines rates the evidence for Ipriflavone: Likely Effective Read what the research shows

    Ipriflavone for osteoporosis

    Most clinical research shows that ipriflavone can prevent loss of bone mineral density (BMD) in postmenopausal adults when taken in combination with calcium 1000 mg daily, with or without estrogen. It may also be beneficial in other patients, including oophorectomized adults and those with vitamin D deficiency.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Estropipate on your own; if you are taking Ipriflavone for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Ipriflavone or Estropipate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ipriflavone or Estropipate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Estropipate

This page covers Ipriflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Estropipate page lists 77 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Aletris (moderate), Alfalfa (moderate) and Androstenediol (moderate).

By severity: 2 major · 61 moderate · 14 minor.

From our pharmacist’s overview on the Estropipate page

“Estropipate (Ogen, Ortho EST) is an estrogen taken for menopause symptoms, and the women who use it are drawn to hormone-touted herbs, which fill this list of 77 ingredients, so it deserves genuine care. Grapefruit is one of two major-rated entries; it blocks the enzyme that clears estrogen, so levels and side effects can climb.”

Reviewed by 2 · Jul 18, 2026

Open the Estropipate interaction page

One more smart check

Taking Ipriflavone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 204 real supplement products containing Ipriflavone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ipriflavone. Even though Ipriflavone itself has no known interaction with Estropipate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ipriflavone and Estropipate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ipriflavone
Top half

#368 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Estropipate
Steady interest

#2,453 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ipriflavone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ipriflavone and Estropipate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ipriflavone

What is Ipriflavone?

Ipriflavone
  • Bone density and osteoporosis
  • Postmenopausal bone loss
  • Athletic performance
  • Tinnitus related to bone disorders

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Because it can lower white blood cell counts in some people and its long-term safety is not well established, talk with your pharmacist or doctor before using it.

Synthetic compound (a semi-synthetic isoflavone derived from soy isoflavones) · Tablets, capsules

An interaction check asks whether these two react with each other — it does not ask whether Ipriflavone is a good idea for someone in your situation. Here is what our Ipriflavone record says about it on its own.

Ipriflavone: dosing

There is no officially established or universally agreed dietary supplement dose for ipriflavone. Doses used in research were studied for osteoporosis and are not a recommendation for general use.If you choose to use a product, follow the directions on the label and do not exceed them. People considering it for bone health should also discuss adequate calcium and vitamin D intake.

From our Ipriflavone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ipriflavone monograph & all interactions
Medication

About Estrogen

What Is Estrogen Used For?

Brand names: Ogen, Ortho EST

Based on the available product information, this Estrogen product is intended for external use on the skin — specifically the face, neck, or body. It is applied as part of a daily skincare routine.

For any specific medical concerns, the label recommends consulting a healthcare provider before use.

See full Estrogen drug information
Keep checking

Other Drugs & Ipriflavone

Browse every other medication we’ve checked against Ipriflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
391Moderate
0Minor
2,438No known interaction
391 Moderate 2,438 No interaction
Moderate

391 interactions

Showing 60 of 391 moderate interactions — see all 391 on the Ipriflavone page.

No interaction 2,438 drugs checked — show the list

We also checked Ipriflavone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,438 medications checked with no known interaction — see the full Ipriflavone list.

See the full Ipriflavone interactions page
See every supplement checked against Estropipate, ranked by severity
Evidence & sources

Ipriflavone References

The 6 references that drive our Ipriflavone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
  2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  3. Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
  4. Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
  5. Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
  6. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ipriflavone and Estropipate Together: Common Questions

Is it safe to take Ipriflavone with Estropipate?
We do not list a known interaction between Ipriflavone and Estropipate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Ipriflavone and Estropipate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ipriflavone in each. That is a conversation for your prescriber, especially if Estropipate is being adjusted to a target.
How was the Ipriflavone and Estropipate combination checked?
Interactions in our licensed database are recorded against drug classes. Estropipate is filed under 2 classifications, and Ipriflavone has documented interactions with 4 drug classes — none of Estropipate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ipriflavone interact with any other medications?
Yes. Ipriflavone has 391 documented drug interactions in our database — Estropipate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Estropipate interact with any supplements?
Yes. Estropipate has documented interactions with 77 supplements in our database — Ipriflavone is not one of them. The Estropipate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ipriflavone monograph Uses, safety profile, and every drug interaction in one place Estrogen drug information The full plain-English guide to this medication Estropipate supplement interactions Every supplement checked against Estropipate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Estropipate and Ipriflavone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.