Medication interaction hub

What Supplements Interact with Ethanol?

Ethanol brand name: Ethanol. Every interaction below applies to the brands too.

65 Interactions 5 Major 38 Moderate 22 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ethanol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ethanol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ethanol used as a medication is still alcohol, and its supplement list calls for real vigilance, starting with the five entries rated major. GHB is the starkest of these, since combining it with alcohol can cause serious sedation, suppressed breathing, and low blood pressure, a risk confirmed in human studies. Most of the rest fall into two patterns: ingredients that add to alcohol's own effects on the brain and body, and ingredients that alter the liver enzyme CYP2E1, which clears alcohol and many other drugs.

A separate cluster, activated charcoal among them, can cut absorption of medicines taken by mouth, so space those well apart from doses and let the full report guide the details. Kava sits in the enzyme group, shown in a human study to slow that pathway. Sixty-five ingredients are on file in all, and though 38 rate moderate and 22 minor, the five majors are why this page deserves a careful read rather than a quick skim.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 38 Minor 22 No known interaction 1,387

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ethanol: Top Interactions at a Glance

The Ethanol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 65 interacting ingredients — plus 1,387 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ethanol Combinations Today

The Ethanol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Durian + Ethanoli

There is a traditional belief that ingestion of alcohol with durian can be fatal.

Read the full interaction Major Likelihood Probable Coca + Ethanoli

Theoretically, concomitant use can increase the risk for neurologic adverse effects.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ethanoli

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Moderate Likelihood Possible Calcium D-glucarate + Ethanoli

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.

Read the full interaction Moderate Likelihood Possible Winter Cherry + Ethanoli

In vitro, winter cherry extract inhibited levels of cytochrome P450 2E1 (CYP2E1).

Read the full interaction Major Likelihood Likely Gamma-hydroxybutyrate (ghb) + Ethanoli

Concomitant use of alcohol and GHB can increase the risk of severe adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Ethanol

All 1,452 ingredients in our database, ranked by severity — 65 with a Ethanol interaction on file and 1,387 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ethanol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Durian with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is a traditional belief that ingestion of alcohol with durian can be fatal.

Full Durian + Ethanol answer

Can you take Coca with Ethanol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use can increase the risk for neurologic adverse effects.

Full Coca + Ethanol answer

Can you take Activated Charcoal with Ethanol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Ethanol answer

Can you take Calcium D-glucarate with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.

Full Calcium D-glucarate + Ethanol answer

Can you take Winter Cherry with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, winter cherry extract inhibited levels of cytochrome P450 2E1 (CYP2E1).

Full Winter Cherry + Ethanol answer

Can you take Gamma-hydroxybutyrate (ghb) with Ethanol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol and GHB can increase the risk of severe adverse effects.

Full Gamma-hydroxybutyrate (ghb) + Ethanol answer

Can you take 1,4-butanediol with Ethanol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, alcohol may increase or decrease the therapeutic and adverse effects of 1,4-butanediol.

Full 1,4-butanediol + Ethanol answer

Can you take Tansy with Ethanol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Thujone, a constituent of tansy, can increase and alter the effects of alcohol.

Full Tansy + Ethanol answer

Can you take Cocoa with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase levels and adverse effects of caffeine.

Full Cocoa + Ethanol answer

Can you take Coffee Charcoal with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Ethanol answer

Can you take Cola Nut with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alcohol might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Ethanol answer

Can you take European Mandrake with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Ethanol answer

Can you take Garlic with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Garlic might increase levels of drugs metabolized by CYP2E1.

Full Garlic + Ethanol answer

Can you take Glucomannan with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Ethanol answer

Can you take Kava with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Kava might increase levels of CYP2E1 substrates.

Full Kava + Ethanol answer

Can you take Niacin with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.

Full Niacin + Ethanol answer

Can you take Resveratrol with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Resveratrol might increase levels of drugs metabolized by CYP2E1.

Full Resveratrol + Ethanol answer

Can you take Tianeptine with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Alcohol increases the clearance and might reduce the levels and clinical effects of tianeptine.

Full Tianeptine + Ethanol answer

Can you take Bilberry with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.

Full Bilberry + Ethanol answer

Can you take Black Hoof Mushroom with Ethanol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP2E1 substrates.

Full Black Hoof Mushroom + Ethanol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ethanol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ethanol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ethanol sits in 4 interaction categories. Open any one to see what the group means:

Alcohol (Ethanol) 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Ethanol through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Ethanol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ethanol through this category.

Alcohol 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ethanol through this category.

Related: does Ethanol deplete any nutrients?

Ethanol has 4 reported nutrient associations in the research literature — see the Ethanol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ethanol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ethanol.

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Products that contain Ethanol-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Ethanol.

Project Ripped by Anabolic Warfare contains Tansy Gallbladder Guard Non-Alcohol by Hawaii Pharm contains Tansy Gallbladder Guard by Hawaii Pharm contains Tansy Tansy by Herbal Terra contains Tansy
Pharmacist Counseling Corner

Ethanol & Supplements: Common Questions

What supplements interact with Ethanol?
Our database currently documents 65 ingredients with a known Ethanol interaction (5 major, 38 moderate, 22 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 65. The highest-ranked right now: Gamma-hydroxybutyrate (ghb), 1,4-butanediol, Activated Charcoal.
Which Ethanol supplement interactions are the most serious?
The 5 major-rated combinations — led by Gamma-hydroxybutyrate (ghb), 1,4-butanediol, Activated Charcoal, Coca and Tansy — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ethanol?
Plenty of supplements coexist fine with Ethanol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Ethanol have the same supplement interactions as Ethanol?
Yes — Ethanol all contain Ethanol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ethanol deplete any vitamins or nutrients?
It might — Ethanol has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ethanol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ethanol and my other medications?
This page covers Ethanol against supplements and herbal ingredients. Checking Ethanol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.