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What Supplements Interact with Ethinyl Estradiol, Ethynodiol Diacetate?

Ethinyl Estradiol, Ethynodiol Diacetate brand names: Demulen 1/35, Zovia 1/35, Demulen Compack, Demulen 1/50, Zovia 1/50, and others. Every interaction below applies to the brands too.

239 Interactions 6 Major 195 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ethinyl Estradiol, Ethynodiol Diacetate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ethinyl Estradiol, Ethynodiol Diacetate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The stakes here are pregnancy prevention, so I read this list with genuine seriousness. Ethinyl estradiol with ethynodiol diacetate (Zovia, Demulen, Kelnor) is a combined birth control pill, and the interactions that concern me most are the ones that can quietly weaken it. St. John's wort speeds up the hormones' breakdown enough to risk contraceptive failure, grapefruit does the opposite and raises hormone levels, and heavy alcohol adds strain on a liver that is already processing estrogen daily.

Everyday items appear here too. Because estrogen slows caffeine clearance, caffeinated drinks can hit harder and linger longer than you expect. Bulking fibers like glucomannan and charcoal products can blunt absorption of any oral pill, so keep them spaced well apart from your dose. Of the 239 ingredients on file, most sit in the moderate column, but the six rated major are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 195 Minor 38 No known interaction 1,213

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ethinyl Estradiol, Ethynodiol Diacetate: Top Interactions at a Glance

The Ethinyl Estradiol, Ethynodiol Diacetate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 239 interacting ingredients — plus 1,213 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ethinyl Estradiol, Ethynodiol Diacetate Combinations Today

The Ethinyl Estradiol, Ethynodiol Diacetate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Selenium + Ethinyl Estradiol, Ethynodiol Diacetatei

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Read the full interaction Minor Likelihood Possible Copper + Ethinyl Estradiol, Ethynodiol Diacetatei

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Read the full interaction Moderate Likelihood Possible Hemp + Ethinyl Estradiol, Ethynodiol Diacetatei

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Moderate Likelihood Possible Wild Yam + Ethinyl Estradiol, Ethynodiol Diacetatei

Theoretically, wild yam might increase or decrease the effects of estrogen.

Read the full interaction Minor Likelihood Unlikely Deer Velvet + Ethinyl Estradiol, Ethynodiol Diacetatei

Theoretically, deer velvet might increase the effects and side effects of estrogens.

Read the full interaction Moderate Likelihood Probable Black Tea + Ethinyl Estradiol, Ethynodiol Diacetatei

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction
The complete list

Every Supplement Checked Against Ethinyl Estradiol, Ethynodiol Diacetate

All 1,452 ingredients in our database, ranked by severity — 239 with a Ethinyl Estradiol, Ethynodiol Diacetate interaction on file and 1,213 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ethinyl Estradiol, Ethynodiol Diacetate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Selenium with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Full Selenium + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Copper with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Full Copper + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Hemp with Ethinyl Estradiol, Ethynodiol Diacetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Wild Yam with Ethinyl Estradiol, Ethynodiol Diacetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wild yam might increase or decrease the effects of estrogen.

Full Wild Yam + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Deer Velvet with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deer velvet might increase the effects and side effects of estrogens.

Full Deer Velvet + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Honey with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Full Honey + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Karaya Gum with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Marshmallow with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Milk Thistle with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, milk thistle might interfere with estrogen therapy through competition for estrogen receptors.

Full Milk Thistle + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Passion Flower with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Puravive with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Sesame with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, sesame might alter the transport of P-glycoprotein substrates.

Full Sesame + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Valerian with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Vitamin D with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Xanthan Gum with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Humann Superbeets Heart Chews with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Jequirity with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Mommy's Bliss Gripe Water with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Polypodium Leucotomos with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Ethinyl Estradiol, Ethynodiol Diacetate answer

Can you take Pomegranate with Ethinyl Estradiol, Ethynodiol Diacetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Ethinyl Estradiol, Ethynodiol Diacetate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ethinyl Estradiol, Ethynodiol Diacetate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ethinyl Estradiol, Ethynodiol Diacetate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ethinyl Estradiol, Ethynodiol Diacetate sits in 11 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ethinyl Estradiol, Ethynodiol Diacetate through this category.

Related: does Ethinyl Estradiol, Ethynodiol Diacetate deplete any nutrients?

Ethinyl Estradiol, Ethynodiol Diacetate has 49 reported nutrient associations in the research literature — see the Ethinyl Estradiol, Ethynodiol Diacetate nutrient depletion report.

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Take a Supplement Product? Check the Whole Bottle Against Ethinyl Estradiol, Ethynodiol Diacetate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ethinyl Estradiol, Ethynodiol Diacetate.

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Pharmacist Counseling Corner

Ethinyl Estradiol, Ethynodiol Diacetate & Supplements: Common Questions

What supplements interact with Ethinyl Estradiol, Ethynodiol Diacetate?
More than you might expect — 239 in total, though they are far from equal: 6 are rated major, 195 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Ethinyl Estradiol, Ethynodiol Diacetate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ethinyl Estradiol, Ethynodiol Diacetate?
Usually yes — most people on Ethinyl Estradiol, Ethynodiol Diacetate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Demulen 1/35 have the same supplement interactions as Ethinyl Estradiol, Ethynodiol Diacetate?
Yes — Demulen 1/35, Zovia 1/35, Demulen Compack, Demulen 1/50, Zovia 1/50 and other brands all contain Ethinyl Estradiol, Ethynodiol Diacetate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ethinyl Estradiol, Ethynodiol Diacetate deplete any vitamins or nutrients?
It might — Ethinyl Estradiol, Ethynodiol Diacetate has 49 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ethinyl Estradiol, Ethynodiol Diacetate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ethinyl Estradiol, Ethynodiol Diacetate and my other medications?
This page covers Ethinyl Estradiol, Ethynodiol Diacetate against supplements and herbal ingredients. Checking Ethinyl Estradiol, Ethynodiol Diacetate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.