Medication interaction hub

What Supplements Interact with Methantheline Bromide?

Methantheline Bromide brand name: Banthine. Every interaction below applies to the brands too.

46 Interactions 3 Major 32 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Methantheline Bromide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Methantheline Bromide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Methantheline bromide (Banthine) is an anticholinergic, prescribed to calm cramping in an overactive gut or bladder, and this list deserves real caution before you add supplements. Three of the 46 entries rate major, and one of them, activated charcoal, shows up in everyday remedies for gas and stomach upset. It can soak up the drug in the gut and cut how much of it reaches you. The other two majors, henbane and scopolia, pile the same drying, heart-racing anticholinergic effects on top of the medicine.

Most of the 32 moderate entries repeat those two patterns. Botanicals with atropine-like alkaloids add side effects such as dry mouth, blurred vision, and constipation, memory herbs that boost acetylcholine can work against the drug, and thick fiber supplements can blunt its absorption. Another 11 rate minor. Space any fiber or charcoal product well apart from your dose, and read the three major entries first.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 32 Minor 11 No known interaction 1,406

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Methantheline Bromide: Top Interactions at a Glance

The most significant Methantheline Bromide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 46 interacting ingredients — plus 1,406 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Methantheline Bromide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Methantheline Bromidei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Henbane + Methantheline Bromidei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Scopolia + Methantheline Bromidei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction
The complete list

Every Supplement Checked Against Methantheline Bromide

All 1,452 ingredients in our database, ranked by severity — 46 with a Methantheline Bromide interaction on file and 1,406 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Methantheline Bromide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bacopa with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might decrease the effectiveness of both agents.

Full Bacopa + Methantheline Bromide answer

Can you take Boxwood with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Full Boxwood + Methantheline Bromide answer

Can you take Calamus with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and calamus might decrease the effectiveness of the anticholinergic drug.

Full Calamus + Methantheline Bromide answer

Can you take Clubmoss with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.

Full Clubmoss + Methantheline Bromide answer

Can you take Corkwood Tree with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, corkwood tree might increase the risk of adverse anticholinergic effects when taken with anticholinergic drugs.

Full Corkwood Tree + Methantheline Bromide answer

Can you take European Barberry with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.

Full European Barberry + Methantheline Bromide answer

Can you take Guar Gum with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Methantheline Bromide answer

Can you take Gum Arabic with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Methantheline Bromide answer

Can you take Huperzine A with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, huperzine A might decrease the effects of anticholinergic drugs.

Full Huperzine A + Methantheline Bromide answer

Can you take Iboga with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga might decrease the effectiveness of anticholinergic drugs.

Full Iboga + Methantheline Bromide answer

Can you take Jimson Weed with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jimson weed may increase anticholinergic effects and adverse effects.

Full Jimson Weed + Methantheline Bromide answer

Can you take Marjoram with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.

Full Marjoram + Methantheline Bromide answer

Can you take Methylene Blue with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may increase anticholinergic effects and adverse effects.

Full Methylene Blue + Methantheline Bromide answer

Can you take Nutmeg with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of nutmeg and anticholinergic drugs might decrease the effectiveness of either agent.

Full Nutmeg + Methantheline Bromide answer

Can you take Phosphatidylserine with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Full Phosphatidylserine + Methantheline Bromide answer

Can you take Poria Mushroom with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.

Full Poria Mushroom + Methantheline Bromide answer

Can you take Purple Nut Sedge with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).

Full Purple Nut Sedge + Methantheline Bromide answer

Can you take Sage with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might decrease the clinical effects of anticholinergic drugs.

Full Sage + Methantheline Bromide answer

Can you take Slippery Elm with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Methantheline Bromide answer

Can you take Syrian Rue with Methantheline Bromide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might decrease the effects of anticholinergic drugs.

Full Syrian Rue + Methantheline Bromide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Methantheline Bromide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Methantheline Bromide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Methantheline Bromide sits in 2 interaction categories. Open any one to see what the group means:

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Methantheline Bromide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Methantheline Bromide through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Methantheline Bromide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Methantheline Bromide.

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Products that contain Methantheline Bromide-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Methantheline Bromide.

Calmhills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Angiplex by UNDA Plex contains Belladonna Back & Neck Pain by BIOVEA Homeopathics contains Belladonna SuperFlex-H by NewtonEverett contains Belladonna CBD+13 by T-Relief contains Belladonna
Pharmacist Counseling Corner

Methantheline Bromide & Supplements: Common Questions

What supplements interact with Methantheline Bromide?
Our database currently documents 46 ingredients with a known Methantheline Bromide interaction (3 major, 32 moderate, 11 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 46. The highest-ranked right now: Activated Charcoal, Henbane, Scopolia.
Which Methantheline Bromide supplement interactions are the most serious?
The 3 major-rated combinations — led by Activated Charcoal, Henbane and Scopolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Methantheline Bromide?
Plenty of supplements coexist fine with Methantheline Bromide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Banthine have the same supplement interactions as Methantheline Bromide?
Yes — Banthine all contain Methantheline Bromide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Methantheline Bromide and my other medications?
This page covers Methantheline Bromide against supplements and herbal ingredients. Checking Methantheline Bromide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.