Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

ALC CLA Ingredients & Drug Interactions

by FINAFLEX

ALC CLA label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ALC CLA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ALC CLA is a dietary supplement by FINAFLEX with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve pain (neuropathy), energy and fatigue.Based on those ingredients, 406 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Safflower Oil powder, Acetyl-L-Carnitine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ALC CLA by FINAFLEX

Ask about any prescription or over-the-counter medication and we check it for interactions with ALC CLA by FINAFLEX — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ALC CLA by FINAFLEX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

ALC CLA contains two active ingredients: acetyl-L-carnitine HCl and safflower oil powder. Acetyl-L-carnitine is a compound that may support energy metabolism and brain function.

Safflower oil is extracted from the safflower plant and contains compounds that may affect blood clotting and blood glucose. The product also contains inactive ingredients — modified food starch, gelatin, calcium silicate, magnesium stearate, maltodextrin, titanium dioxide, and color additives FD&C Red #40 and FD&C Blue #1 — which serve as binders, fillers, and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: stimulant-free weight management and fat metabolism.
  • We looked for evidence on: Athletic performance, Cancer-related fatigue, Chronic fatigue syndrome (CFS), Obesity, Body composition, Lean muscle mass — and 1 related terms.
  • The closest evidence on file: Safflower is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Acetyl-l-carnitine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Cancer-related fatigue, Chronic fatigue syndrome (CFS), Obesity.

The evidence supporting acetyl-L-carnitine for its marketed uses comes largely from animal and laboratory research. Our data rates it as possibly effective for age-related cognitive decline, Alzheimer disease, alcohol use disorder, diabetic neuropathy, and depression — meaning there's some evidence but it's not conclusive.

For safflower oil, the evidence is weaker still; we hold insufficient reliable evidence to rate its use for unstable angina, coronary heart disease, cystic fibrosis, diabetes, or diabetic kidney disease. If you're considering this product for a specific health concern, ask your pharmacist or doctor what the current clinical evidence supports.

The evidence, ingredient by ingredient Acetyl-l-carnitine Safflower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Acetyl-L-carnitine is generally well tolerated over the short term, but long-term safety isn't fully established. Common side effects include agitation, dry mouth, headache, insomnia, reduced appetite, and a fishy odor in urine, breath, or sweat.

In people with Alzheimer disease, psychiatric effects like depression, mania, confusion, or aggression have been reported, though it's unclear whether they're from the supplement or the condition itself. Safflower oil in normal food amounts is well tolerated, but safflower supplements — especially at high doses — have less safety data.

Concerning case reports link safflower overuse to liver failure, though the exact dose and duration that caused harm weren't always clear. The safety data advises against acetyl-L-carnitine in pregnancy and during breastfeeding.

For safflower, safety during breastfeeding is unknown beyond normal food use, so medicinal amounts are best avoided.

Side effects, ingredient by ingredient Acetyl-l-carnitine Safflower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Safflower, Acetyl-l-carnitine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 406 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take ALC CLA, double-check with your pharmacist if you're on serotonergic drugs like antidepressants or migraine medications (moderate severity), blood thinners including warfarin or acenocoumarol or antiplatelet drugs (moderate), thyroid hormone replacement (moderate), or diabetes medications (moderate). No interactions are documented for the ingredients we could check against other drug classes, but that's not a guarantee none exist — the checker below is your best tool.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

ALC CLA may be worth considering if you're interested in acetyl-L-carnitine or safflower oil and have no blood thinners, serotonergic medications, thyroid medications, or blood sugar medications in your routine. If you do take any of those, or any blood-pressure drugs, talk to your pharmacist before adding this supplement — the interaction checker on this page is your first step.

Pregnant or breastfeeding? Skip this one.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ALC CLA, straight from the product label.

Brand FINAFLEX
Barcode (UPC) 689466670042
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247659
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ALC CLA by FINAFLEX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
689466670042
IngredientAmount% DV
Acetyl-L-Carnitine HCl800 mg--
Safflower Oil powder1920 mg--

Other ingredients: modified Food Starch, Gelatin, Calcium Silicate, Magnesium Stearate, Maltodextrin, Titanium Dioxide, FD&C Red #40, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

2.7 formula

Sold by total capsule count not by volume. Redefine yourself

Formulation

Ultimate weight loss

Stim free weight management Healthy body composition Use stored fat as energy Promote fat metabolism Support lean muscle

How does ALC CLA work in the body? Use stored fat as energy + Lean muscle + Weight loss

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Introducing ALC CLA FINAFLEX ALC CLA is an Ultimate Weight Loss product that combines Acetyl L-Carnitine (ALC) with CLA (Conjugated Linoleic Acid), creating a uniquely effective stimulant-free healthy lifestyle product. ALC CLA promotes healthy body composition by reducing body fat, increasing lean muscle mass, and supporting cellular energy, enabling cells to metabolize fat, turning it into energy. Use ALC CLA daily to help support a healthy lifestyle.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 serving (4 capsules) of ALC CLA daily with meals.

Precautions

Warning: Keep out of reach of children.

Do not use if pregnant or nursing.

Consult your doctor or other qualified medical authority prior to use of this product if you have any medical condition, have a family history of medical conditions, or if you are currently taking any other medicines or dietary supplements.

This product is intended for use by healthy adults over the age of 18 years old.

Do not exceed recommended dosage. Stop using immediately if you experience any adverse symptoms or reactions to this product. Do not use for more than 8 weeks consecutively. Discontinue 2 weeks prior to surgery.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ALC CLA by FINAFLEX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ALC CLA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ALC CLA by FINAFLEX

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Acetyl-L-Carnitine HCl

Interacts with
203 drugs
800 mg per serving

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and mem...

Acetyl-L-Carnitine HCl monograph & interactions

Safflower Oil powder

Interacts with
208 drugs
1920 mg per serving Form: Conjugated Linoleic Acid

Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source o...

Safflower Oil powder monograph & interactions

Other (inactive) ingredients: Modified Food Starch, Gelatin, Calcium Silicate, Magnesium Stearate, Maltodextrin, Titanium Dioxide, FD&C Red #40, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

ALC CLA by FINAFLEX Drug Interactions

Want to check YOUR meds against ALC CLA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
406Drugs
406 Moderate

Ingredients driving the most interactions

Safflower Oil powder 208
Acetyl-L-Carnitine HCl 203

Individual Drug Interactions

The ingredients in ALC CLA interact with 406 drugs. Click any drug to see the details.

2 of the 2 ingredients in ALC CLA interact with drugs. Each result below shows which ingredient is responsible. Safflower Oil powder Acetyl-L-Carnitine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in ALC CLA with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Safflower Oil powder3 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Small clinical studies show that taking safflower oil, approximately 55 grams daily for 2-3 weeks, decreases platelet aggregation. However, taking lower doses of safflower oil, such as 5 grams daily for 4 weeks, does not seem to affect platelet function. In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Some clinical research shows that taking safflower oil 10 grams daily for 3 weeks can increase fasting blood glucose in patients with type 2 diabetes. However, clinical research in patients with metabolic syndrome with or without impaired glucose tolerance shows that taking safflower oil 8 grams daily for 12 weeks reduces fasting glucose levels by around 8 mg/dL. Some clinical research also shows that taking safflower oil 8 grams daily for 16 weeks does not affect fasting glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence B
Warfarin

Theoretically, safflower oil might increase the risk of bleeding when taken with warfarin.
In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence D
Safflower Oil powder full monograph & interactions

Acetyl-L-Carnitine HCl4 drug types · 203 drugs

Acenocoumarol (Sintrom)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of acetyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant that is similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with acetyl-L-carnitine.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Animal research shows that acetyl-L-carnitine can increase levels of serotonin in the brain.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with acetyl-L-carnitine.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of acetyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with acetyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Acetyl-L-Carnitine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ALC CLA, from the product label.

FINAFLEX

See all FINAFLEX products
Name
FINAFLEX
Street Address
3615 Francis Cir Ste 100
City
Alpharetta
State
GA
ZipCode
30004
Phone Number
888.678.7629
Web Address
FINAFLEX.com
Pharmacist Counseling Corner

ALC CLA by FINAFLEX: Common Questions

Does ALC CLA by FINAFLEX interact with any medications?
Yes. Based on its ingredients, ALC CLA has a known interaction with 406 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ALC CLA contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interact with my antidepressant?
Yes — the acetyl-L-carnitine in this product has a moderate-severity interaction with serotonergic drugs like antidepressants. It may increase the risk of serotonin syndrome and related side effects. Talk to your pharmacist or doctor before starting, even if you've used other supplements safely.
What are the most common side effects?
For acetyl-L-carnitine, the most common are agitation, dry mouth, headache, insomnia, and loss of appetite. A side effect that surprises people is a fishy odor in urine, breath, or sweat. Gastrointestinal upset can happen but doesn't appear to be much more common than with placebo.
Can I take this if I'm on warfarin?
No — both ingredients in this product have moderate-severity interactions with warfarin. Acetyl-L-carnitine may increase warfarin's blood-thinning effects, and safflower oil raises the risk of bleeding. This combination is a real concern, so skip this product if you're on warfarin or talk to your doctor first.
Is it safe to take while breastfeeding?
No. The safety data advises against acetyl-L-carnitine during breastfeeding, and safflower safety while breastfeeding is unknown beyond normal food amounts. It's best to avoid this supplement while nursing.
Does this actually work for cognitive decline?
Acetyl-L-carnitine is rated possibly effective for age-related cognitive decline and Alzheimer disease, meaning some evidence suggests it may help — but the evidence isn't strong or conclusive. The safflower oil component doesn't have reliable evidence for any of the conditions listed.
Can I take this if I'm on thyroid medication?
Talk to your pharmacist first. Acetyl-L-carnitine has a moderate-severity interaction with thyroid hormone replacement and may reduce how well it works. Your doctor or pharmacist can help you decide if the timing or dose needs to change.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ALC CLA label
Go deeper

The Full Monographs Behind ALC CLA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Acetyl-l-carnitine

Interacts with 203 drugs

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evide...

Read the full Acetyl-l-carnitine monograph → Herb & supplement monograph

Safflower

Interacts with 208 drugs

Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source of unsaturated fats, but strong proof tha...

Read the full Safflower monograph →
Sources

Sources & How We Checked

ALC CLA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Acetyl-l-carnitine 22 references
  1. Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. Neurology 1996;47:705-11. PubMed
  2. Sano M, Bell K, Cote L, et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. Arch Neurol 1992;49:1137-41. PubMed
  3. Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. Neurology 1991;41:1726-32. PubMed
  4. Brooks JO 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int Psychoger 1998;10:193-203. PubMed
  5. Pettegrew JW, Klunk WE, Panchalingam K, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiol Aging 1995;16:1-4. PubMed
  6. Rai G, Wright G, Scott L, et al. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Curr Med Res Opin 1990;11:638-47. PubMed
  7. Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
  8. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003;18:61-71.. PubMed
  9. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
  10. Hudson S, Tabet N. Acetyl-L-carnitine for dementia. Cochrane Database Syst Rev 2003;2:CD003158.. PubMed
  11. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
  12. De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study. Drugs R D 2002;3:223-31. PubMed
  13. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
  14. Sima AAF, Calvani M, Mehra M, et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized, placebo-controlled trials. Diabetes Care 2005;28:89-94.
  15. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV.Med. 2007;8(4):241-250.
  16. Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG Jr, Renshaw PF, Cohen BM. A placebo-controlled trial of acetyl-L-carnitine and a-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol. 2013 Oct;33(5):627-35.
  17. Ledinek AH, Sajko MC, Rot U. Evaluating the effects of amantadin, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis--result of a pilot randomized, blind study. Clin Neurol Neurosurg. 2013 Dec;115 Suppl 1:S86-9. PubMed
  18. Martinotti G, Andreoli S, Reina D, Di Nicola M, Ortolani I, Tedeschi D, Fanella F, Pozzi G, Iannoni E, D'Iddio S, Prof LJ. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. Prog Neuropsychop PubMed
  19. Baek SM, Zheng R, Seo EJ, Hwang DY, Kim BH. Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers. Int J Clin Pharmacol Ther. 2015;53(11):980-6. PubMed
  20. Goodison G, Overeem K, de Monte V, Siskind D. Mania associated with self-prescribed acetyl-l-carnitine in a man with bipolar I disorder. Australas Psychiatry. 2017;25(1):13-4.
  21. Bruno A, Pandolfo G, Crucitti M, Lorusso S, Zoccali RA, Muscatello MR. Acetyl-L-Carnitine Augmentation of Clozapine in Partial-Responder Schizophrenia: A 12-Week, Open-Label Uncontrolled Preliminary Study. Clin Neuropharmacol. 2016;39(6):277-80. PubMed
  22. Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom Med. 2018;80(2):154-9. PubMed

See these in context on the Acetyl-l-carnitine monograph →

Safflower 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 1989;38:1314-9.. PubMed
  5. Amato, P. and Quercia, R. A. A historical perspective and review of the safety of lipid emulsion in pregnancy. Nutr Clin Pract. 1991;6(5):189-192. PubMed
  6. Demke, D. M., Peters, G. R., Linet, O. I., Metzler, C. M., and Klott, K. A. Effects of a fish oil concentrate in patients with hypercholesterolemia. Atherosclerosis 1988;70(1-2):73-80. PubMed
  7. Kaji, K., Yoshida, S., Nagata, N., Yamashita, T., Mizukoshi, E., Honda, M., Kojima, Y., and Kaneko, S. An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C. J Gastroenterol. 2004;39(9):873-878. PubMed
  8. Kwon, J. S., Snook, J. T., Wardlaw, G. M., and Hwang, D. H. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. Am.J.Clin.Nutr. PubMed
  9. Lloyd-Still, J. D., Simon, S. H., Wessel, H. U., and Gibson, L. E. Negative effects of oral fatty acid supplementation on sweat chloride in cystic fibrosis. Pediatrics 1979;64(1):50-52. DOI
  10. Challen, A. D., Branch, W. J., and Cummings, J. H. The effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man. Hum Nutr Clin Nutr 1983;37(3):197-208.
  11. Asp ML, Collene AL, Norris LE, Cole RM, Stout MB, Tang SY, Hsu JC, Belury MA. Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, cro
  12. Liu Y, Liu S, Shi Y, et al. Effects of safflower injection on the pharmacodynamics and pharmacokinetics of warfarin in rats. Xenobiotica. 2017 Oct 25:1-6. [Epub ahead of print] PubMed
  13. de Ataide EC, Reges Perales S, de Oliveira Peres MA, et al. Acute liver failure induced by Carthamus tinctorius oil: Case reports and literature review. Transplant Proc. 2018;50(2):476-477. PubMed
  14. Ruyvaran M, Zamani A, Mohamadian A, et al. Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial. PubMed

See these in context on the Safflower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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