Aloe Vera 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Aloe Vera 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Aloe Vera 500 mg is a dietary supplement by Botanic Choice with 1 active ingredient. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Cape Aloe latex powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Aloe Vera 500 mg by Botanic Choice
Ask about any prescription or over-the-counter medication and we check it for interactions with Aloe Vera 500 mg by Botanic Choice — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Aloe Vera 500 mg by Botanic Choice
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Cape Aloe latex powder at 500 mg per capsule. Aloe latex is the yellow fluid found just under the plant's skin — different from aloe gel, which comes from inside the leaf.
The capsule itself is gelatin, and rice flour is used as an inactive filler.
Does it work?
Moderate evidence
The evidence for aloe supports "possibly effective" for six conditions: acne, obesity, diabetes, psoriasis, burns, and constipation. That means preliminary research looks promising, but we don't yet have enough high-quality studies to call it proven.
If you're thinking about it for one of these purposes, talk with your pharmacist or doctor about what the current evidence shows for your specific situation.
How safe is it?
Well-documented data
Oral aloe latex — which is what's in this capsule — carries more risk than topical aloe gel. The most common side effects are abdominal pain, cramps, and diarrhea.
With long-term or heavy use, you might develop more serious effects including potassium loss (hypokalemia), muscle weakness, and heart rhythm problems (arrhythmia). One documented case involved severe potassium depletion in someone taking a very high dose daily for two weeks.
Do not take this product during pregnancy — aloe latex can stimulate the uterus and act as a strong laxative. Avoid it while breastfeeding too, because safety data is limited and the laxative effects could affect your baby.
If you're pregnant or nursing and interested in aloe, talk with your doctor or pharmacist first.
Meds to double-check
Major interaction found
Before taking this aloe latex product, check with your pharmacist if you use digoxin (Lanoxin) or any blood thinner — these are Major or Moderate interactions. Also double-check if you take diabetes medications, water pills (diuretics), stimulant laxatives, or warfarin specifically.
If you're on any heart, blood, or diabetes medication, your pharmacist can run your exact drugs through the interaction checker on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
This aloe latex product may help with acne, burns, constipation, diabetes, psoriasis, or weight, but the evidence is still preliminary. It's not a substitute for medical treatment of serious conditions.
Do not use it if you take digoxin, blood thinners, diabetes medications, water pills, or other stimulant laxatives without checking with your pharmacist first. If you're pregnant or breastfeeding, skip it.
Anyone considering this should discuss it with their pharmacist or doctor.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Aloe Vera 500 mg, straight from the product label.
| Brand | Botanic Choice |
|---|---|
| Barcode (UPC) | 703308060041 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2019 |
| DSLD ID | 199481 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Aloe Vera 500 mg by Botanic Choice, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cape Aloe latex powder | 500 mg | -- |
Other ingredients: Rice Flour, Gelatin Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
General Statements
Trusted since 1910 Essentials
Formulation
Gluten free Non GMO
Seals/Symbols
Gluten free Non GMO
Formula
Leaf and latex
Notice: This product contains Aloe Vera.
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 capsule daily, with meals, as a dietary supplement, or as directed by a health care professional.
Precautions
Notice: This product contains Aloe Vera. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because Aloe Vera may worsen these conditions and be harmful to your health.
Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.
Not for long-term use.
For your protection, this container has an outer safety seal. (Do not accept if missing or broken.)
Keep out of reach of children
Storage
Best if used by date on bottle. Store in a dry, cool place.
Brand IP Statement(s)
IBG Indiana Botanic Gardens
General
C-107834
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Aloe Vera 500 mg by Botanic Choice label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Aloe Vera 500 mg by Botanic Choice
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Cape Aloe latex powder
Interacts with461 drugs
Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...
Cape Aloe latex powder monograph & interactionsOther (inactive) ingredients: Rice Flour, Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.
Aloe Vera 500 mg by Botanic Choice Drug Interactions
HelloPharmacist Interaction Report
Botanic Choice Aloe Vera 500 mg contains Cape Aloe latex powder, which has a number of documented interactions with medications.
The most serious is with digoxin (Lanoxin), a heart rhythm medication — overuse of aloe latex can deplete potassium, which increases the risk of digoxin toxicity and its harmful side effects.
Read the full breakdown — every affected drug type, severity by severity
Aloe latex also interacts with blood thinners (anticoagulants) and antiplatelet drugs like warfarin and aspirin — it may increase bleeding risk, especially since aloe can cause diarrhea, which itself can boost warfarin's effects. You'll want to be cautious with diabetes medications too: aloe may lower blood sugar, which could lead to low blood sugar (hypoglycemia) if you're also on antidiabetes drugs.
Monitor your levels closely. Altogether, these interactions span 460 individual medications.
Additionally, aloe latex may increase potassium loss when combined with water pills (diuretics), and it shouldn't be taken alongside other stimulant laxatives — both combinations raise the risk of fluid and electrolyte imbalance. There's also a minor interaction with certain drugs metabolized by a liver enzyme (CYP1A2 substrates), where aloe might reduce their effectiveness.
Before you start this product, run your exact medications through the checker on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Aloe Vera 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Aloe Vera 500 mg interact with 461 drugs. Click any drug to see the details.
1 of the 1 ingredient in Aloe Vera 500 mg interact with drugs. Each result below shows which ingredient is responsible. Cape Aloe latex powder
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderDigoxin (lanoxin) Major
Interaction Summary
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Read the full Cape Aloe Latex Powder + Digoxin interactionAbciximabReoPro
How Abciximab interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe Latex Powder + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Cape Aloe Latex Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Cape Aloe Latex Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Cape Aloe Latex Powder + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe Latex Powder + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe Latex Powder + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe Latex Powder + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe Latex Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe Latex Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe Latex Powder + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe Latex Powder + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cape Aloe Latex Powder + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Cape Aloe Latex Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Cape Aloe Latex Powder + Argatroban interactionArmodafinilNuvigil
How Armodafinil interacts with Aloe Vera 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cape Aloe Latex PowderStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Cape Aloe Latex Powder + Armodafinil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Aloe Vera 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cape Aloe latex powder
Digoxin (Lanoxin)
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.
Anticoagulant/Antiplatelet Drugs
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.
Antidiabetes Drugs
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.
Diuretic Drugs
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.
Stimulant Laxatives
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.
Brand information
Manufacturer and brand details for Aloe Vera 500 mg, from the product label.
Botanic Choice
See all Botanic Choice products- Name
- Indiana Botanic Gardens, Inc.
- Street Address
- 3401 W. 37th Ave.
- City
- Hobart
- State
- IN
- ZipCode
- 46342
- Phone Number
- 1-800-644-8327
- Web Address
- www.botanicchoice.com
Aloe Vera 500 mg by Botanic Choice: Common Questions
Does Aloe Vera 500 mg by Botanic Choice interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is aloe latex the same as aloe gel?
What are the most common side effects of taking this?
Can I take this if I'm pregnant or breastfeeding?
Does aloe really help with constipation?
Can I take this with my diabetes medication?
How long can I safely take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Aloe Vera 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Aloe Vera 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Aloe Vera 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Aloe 41 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
- Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
- Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
- Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
- Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
- Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
- Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
- Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
- Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
- Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
- Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
- Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
- Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
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