Major interaction on record — check this product against your medications before combining. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Amino Complete Ingredients & Drug Interactions

by NOW Sports

Amino Complete label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amino Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amino Complete is a dietary supplement by NOW Sports with 6 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 526 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin B6, Whey Protein Isolate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amino Complete by NOW Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with Amino Complete by NOW Sports — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Amino Complete by NOW Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “Amino Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Blend of Peptide-Bound Amino Acid Sources” is a proprietary blend — the label gives one combined amount (2.80 Gram(s)) without saying how much of each component you get.

Amino Complete contains 7 active ingredients that work together as an amino acid supplement. L-glutamine and L-ornithine are individual amino acids, while whey protein isolate, soy protein isolate, and sodium caseinate are concentrated protein sources that supply multiple amino acids.

The product also contains a blend of peptide-bound amino acids (amino acids linked together) and general amino acids. Together, these provide the building blocks your body uses to build and repair muscle tissue and support recovery.

The capsule itself is made from hypromellose and hydroxypropyl cellulose, with stearic acid and silicon dioxide as processing aids.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Complete amino acid protein supplementation.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Malnutrition, HIV/AIDS-related wasting, Critical illness (trauma) — and 4 related terms.
  • The strongest evidence on file: Ornithine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Whey Protein is rated "Possibly Effective" for Athletic performance.
  • Also on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting, Critical illness (trauma).

The evidence for effectiveness in this product varies by ingredient and use. L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and recovery from critical illness or trauma.

Whey protein is possibly effective for athletic performance but possibly ineffective for osteoporosis and COPD; the evidence for age-related cognitive decline and HIV/AIDS-related wasting is insufficient to rate. L-ornithine is possibly effective for athletic performance, but evidence for dry skin, insomnia, and periodontitis is insufficient.

Sodium caseinate shows possibly ineffective results for infant development and insufficient evidence for other uses like athletic performance and diabetes. No effectiveness ratings are available for L-arginine, soy protein isolate, or the amino acid blends in the product facts we hold.

The evidence, ingredient by ingredient Vitamin B6 Whey Protein Casein Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated but people with kidney or liver disease should use it only under medical supervision; it's likely safe in pregnancy and lactation. Common side effects are gastrointestinal—belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting—along with headache and musculoskeletal pain.

Vitamin B6 is safe at normal food and supplement amounts, but high doses over time can damage nerves (sensory neuropathy); it's generally well tolerated below 100 mg daily. Whey protein is generally well tolerated by most healthy adults but concentrated supplements aren't well studied, so check with your doctor; common side effects are acne, bloating, cramps, diarrhea, headache, nausea, reflux, and reduced appetite.

L-arginine is often well tolerated short-term but lowers blood pressure and safety isn't established for self-treatment; common side effects include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing. Sodium caseinate is generally safe for people who tolerate dairy, though concentrated supplements should be discussed with your doctor first.

L-ornithine is generally well tolerated short-term but long-term safety isn't well studied. Pregnancy and lactation safety data aren't available for L-arginine, whey protein, L-ornithine, or sodium caseinate.

Side effects, ingredient by ingredient Vitamin B6 Whey Protein Casein Protein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Whey Protein, L-arginine, Glutamine, Vitamin B6.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; Parkinson's medications.
  • For scale: 526 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Amino Complete, check with your pharmacist if you're on levodopa (Parkinson's disease)—whey protein here has a Major interaction that can worsen symptoms. Also double-check if you take any anticonvulsants like phenytoin or phenobarbital, blood pressure drugs (ACE inhibitors, ARBs, or other antihypertensives), blood thinners (anticoagulants or antiplatelet drugs), diabetes medications, potassium-sparing diuretics, amiodarone, sildenafil (Viagra), quinolone or tetracycline antibiotics, or bisphosphonates.

All these have Moderate interactions documented with ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Amino Complete is an amino acid blend that may help with muscle recovery and athletic performance, but it's not for everyone. If you take levodopa for Parkinson's, blood pressure medications, blood thinners, diabetes drugs, or anticonvulsants, you need to check your specific medications with your pharmacist before starting.

People with kidney or liver disease should talk to their doctor first, as should anyone taking prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amino Complete, straight from the product label.

Brand NOW Sports
Barcode (UPC) 733739000132
Net contents 360 Veg Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 314236
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amino Complete by NOW Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Veg Capsule(s)
Maximum serving Sizes:
4 Veg Capsule(s)
Servings per container
90
UPC/BARCODE
733739000132
IngredientAmount% DV
Calories10 Calorie(s)--
L-Glutamine0 NP--
Vitamin B613 mg765%
Whey Protein Isolate0 NP--
L-Arginine0 NP--
Protein2 Gram(s)4%
Soy Protein isolate0 NP--
L-Ornithine0 NP--
Sodium Caseinate0 NP--
Amino Acids0 NP--
Blend of Peptide-Bound Amino Acid Sources2.8 Gram(s)--

Other ingredients: Hypromellose, Hydroxypropyl Cellulose, Stearic Acid, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 4 capsules daily, preferably with juice.

Precautions

Caution: For adults only. Keep out of reach of children.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Contains milk and soy.

Not manufactured with wheat, gluten, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

EUA # 1482865

Steroid tested Non-GMO

Made and quality tested in the USA with globally sourced ingredients.

Not manufactured with wheat, gluten, egg, fish, shellfish, tree nut or sesame ingredients.

General Statements

Typical Amino Acid Profile (example) (per serving) Essential Amino Acids mg per 4 capsule serving L-Histidine 37 L-Isoleucine 115 L-Leucine 205 L-Lysine 185 L-Methionine 35 L-Phenylalanine 72 L-Threonine 141 L-Tryptophan 37 L-Valine 141 Non-Essential Amino Acids mg per 4 capsule serving L-Alanine 97 L-Arginine 276 L-Aspartic Acid 220 L-Cysteine 38 L-Glutamic Acid 410 L-Glutamine 204 Glycine 47 L-Ornithine 31 L-Proline 123 L-Serine 106 L-Tyrosine 66 Subject to natural variability Branched-Chain Amino Acids

Seals/Symbols

Crescent H (Halal) GMP Quality Assured Informed Sport We Test - You Trust Triangle K D (Kosher Dairy)

Formula

Crescent H (Halal)

Triangle K D (Kosher Dairy)

Amino acids Protein blend 20 aminos with vit. B-6

FDA Statement of Identity

A Dietary Supplement

Storage

Store in a cool, dry, dark place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amino Complete by NOW Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amino Complete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amino Complete by NOW Sports

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Veg Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
13 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Protein

2 Gram(s) per serving

Blend of Peptide-Bound Amino Acid Sources

2.8 Gram(s) per serving

Other (inactive) ingredients: Hypromellose, Hydroxypropyl Cellulose, Stearic Acid, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amino Complete by NOW Sports Drug Interactions

Want to check YOUR meds against Amino Complete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
526Drugs
5 Major 513 Moderate 8 Minor

Ingredients driving the most interactions

Vitamin B6 210
Whey Protein Isolate 53

Individual Drug Interactions

The ingredients in Amino Complete interact with 526 drugs. Click any drug to see the details.

2 of the 6 ingredients in Amino Complete interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Whey Protein Isolate

Each ingredient & the kinds of drugs it affects

For each ingredient in Amino Complete with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Whey Protein Isolate4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Whey Protein Isolate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amino Complete, from the product label.

NOW Sports

See all NOW Sports products
Name
NOW FOODS
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.nowsportsproducts.com
Pharmacist Counseling Corner

Amino Complete by NOW Sports: Common Questions

Does Amino Complete by NOW Sports interact with any medications?
Yes. Based on its ingredients, Amino Complete has a known interaction with 526 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amino Complete contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Amino Complete safe during pregnancy and breastfeeding?
L-glutamine is likely safe in pregnancy and lactation. However, we don't have enough safety data on file for L-arginine, whey protein, L-ornithine, or sodium caseinate during pregnancy or breastfeeding. L-ornithine specifically advises against use unless your doctor recommends it. Talk with your doctor or pharmacist before using this product while pregnant or nursing.
What amino acids are in this product?
Amino Complete contains L-glutamine, L-arginine, and L-ornithine as individual amino acids, plus three protein sources—whey protein isolate, soy protein isolate, and sodium caseinate—that provide a full spectrum of amino acids your body needs.
Does this product have side effects?
The most common side effects are gastrointestinal: bloating, cramping, diarrhea, nausea, and abdominal pain. You may also experience headache, fatigue, reduced appetite, or flushing. Most side effects are dose-related, so starting with a smaller amount may help.
What is whey protein isolate, and why is it in here?
Whey protein isolate is a concentrated form of whey—a protein from milk. It's in this product to provide amino acids that support muscle building and recovery, especially after exercise.
Can I take this if I have liver or kidney disease?
L-glutamine is in this product, and people with kidney or liver disease should only use it under medical supervision. Check with your doctor before starting.
Does Amino Complete actually work for athletic performance?
Whey protein and L-ornithine are both possibly effective for athletic performance based on the evidence we have. L-glutamine is effective for certain specific conditions like sickle cell disease, but the evidence for general athletic performance isn't rated in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Amino Complete is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amino Complete label
Go deeper

The Full Monographs Behind Amino Complete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph → Herb & supplement monograph

Casein Protein

Casein is a slow-digesting protein from milk that supplies all the essential amino acids and is popular for muscle recovery, especially overnight. It is generally safe for most people who to...

Read the full Casein Protein monograph →
Sources

Sources & How We Checked

Amino Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 196 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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