Major interaction on record — check this product against your medications before combining. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

AngiNOX Elite Natural Fruit Punch Flavor Ingredients & Drug Interactions

by XYMOGEN

AngiNOX Elite Natural Fruit Punch Flavor label
See full label image
Powder Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AngiNOX Elite Natural Fruit Punch Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

AngiNOX Elite Natural Fruit Punch Flavor is a dietary supplement by XYMOGEN with 5 active ingredients. Its ingredients are commonly taken for high blood pressure, erectile dysfunction, athletic performance.Based on those ingredients, 1,071 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Pomanox, L-Arginine, Hawthorn Flower, Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

AngiNOX Elite has 5 active ingredients. L-Arginine is an amino acid that increases nitric oxide to help open blood vessels.

L-Citruline is another amino acid that supports nitric oxide production. Hawthorn Flower and Leaf Extract is an herb traditionally used for heart health.

Pomanox is a pomegranate extract. Folate is a B vitamin.

The product also contains inactive ingredients — natural flavors, citric acid, red beet powder, malic acid, monk fruit extract, stevia leaf extract, and sea salt — which serve as sweeteners, thickeners, and flavor.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Heart and blood vessel health support.
  • We looked for evidence on: Angina, Arrhythmia, Atherosclerosis, Cardiovascular disease (CVD), Congestive heart failure (CHF), Coronary heart disease (CHD) — and 4 related terms.
  • The strongest evidence on file: Pomegranate is rated "Possibly Effective" for Hypertension (Natural Medicines).
  • Also on file: Pomegranate is rated "Possibly Ineffective" for Hyperlipidemia.
  • Also on file: Pomegranate is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Coronary heart disease (CHD), Stroke.

The data we hold does not establish effectiveness ratings for AngiNOX Elite as a whole product. For individual ingredients, pomegranate is rated possibly effective for high blood pressure and possibly ineffective for high cholesterol and diabetes.

Hawthorn's effectiveness for angina, anxiety, arrhythmia, atherosclerosis, cardiovascular disease, and cognitive function is rated insufficient evidence to establish. No effectiveness data is on file for L-Arginine, L-Citruline, or Folate in this dataset.

The evidence, ingredient by ingredient L-arginine Pomegranate Hawthorn

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Arginine is generally well tolerated short-term but can lower blood pressure and may not be safe for everyone — use only under medical supervision, as safety for self-treatment is not well established. Common oral side effects include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.

When inhaled, it can inflame airways in people with asthma, though oral doses in asthma patients studied did not show this effect. Pomegranate fruit and juice are generally safe in normal food amounts; concentrated extracts should be used with caution due to limited safety data, though diarrhea and flatulence are the most common mild effects at higher doses.

Hawthorn seems well tolerated in studies but is not recommended during pregnancy or breastfeeding due to insufficient safety information. No pregnancy or breastfeeding data is on file for Folate, L-Citruline, or L-Arginine in this product's monograph.

Side effects, ingredient by ingredient L-arginine Pomegranate Hawthorn

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Pomegranate, Hawthorn, L-arginine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,072 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take nitrates or phosphodiesterase-5 inhibitors (like sildenafil/Viagra) — Major risk of dangerous blood pressure drops with hawthorn. Also double-check if you're on ACE inhibitors, ARBs, other blood pressure medications, blood thinners (anticoagulants or antiplatelets), beta-blockers, calcium channel blockers, digoxin, diabetes drugs, warfarin, rosuvastatin, or drugs metabolized by your liver's CYP2D6 enzyme (Moderate to Minor risks).

The medication search tool on this page will help you verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

AngiNOX Elite contains ingredients that lower blood pressure and affect bleeding risk, so it's important for anyone on heart or blood pressure medications to check with their pharmacist first. If you take nitrates, blood thinners, ACE inhibitors, ARBs, beta-blockers, PDE-5 inhibitors, or digoxin, you need to have a conversation before starting.

Pregnant or breastfeeding individuals should avoid hawthorn and talk to their doctor about the other ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AngiNOX Elite Natural Fruit Punch Flavor, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 722537512671
Net contents 30 Stick Pack(s); 4.76 Ounce(s); 135 Gram(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 335420
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4.5 Gram(s)
Maximum serving Sizes:
4.5 Gram(s)
Servings per container
30
UPC/BARCODE
722537512671
IngredientAmount% DV
Folate680 mcg DFE170%
Calories20 Calorie(s)--
Total Carbohydrate1 Gram(s)1%
L-Citruline1.5 Gram(s)--
L-Arginine500 mg--
Pomanox375 mg--
Hawthorn Flower, Leaf Extract50 mg--

Other ingredients: Natural flavors, Citric Acid, Red Beet, Powder, Malic Acid, Monk Fruit Extract, Stevia leaf extract, Sea Salt

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

GMP Compliant Third-Party Verified

NSF Certified Sport

Brand IP Statement(s)

Copyright 2024 XYMOGEN

Quatrefolic S1. Quatrefolics is a registered trademark of Gnosis S.p.A. Produced under U.S. patent 7,947,662. Pomanox S2. Pomanox is a registered trademark of Euromed S.A.

Xymogen Professional Formulas

Suggested/Recommended/Usage/Directions

Directions: Dissolve the contents of one stick pack in 8-10 oz of water according to preferred taste. Consume once daily, or use as directed by your healthcare professional.

Precautions

Consult your healthcare professional prior to use. Do not use if stick pack is damaged.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Storage: Keep closed in a cool, dry place out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation

Formulated to exclude: Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Vascular Performance Enhancer

AngiNOX Elite is designed to boost the generation of nitric oxide, a naturally occurring biological compound produced in the vascular endothelium that supports healthy blood flow and vascular function. This formula contains a unique combination of beneficial ingredients delivered in a lightly flavored powder that easily mixes into water.

General Statements

30 Stick Packs 0.16 oz (4.5 g)

Choose your expert. Change your health. Scan to learn

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AngiNOX Elite Natural Fruit Punch Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4.5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Folate

680 mcg DFE per serving Form: Quatrefolic

L-Citruline

1.5 Gram(s) per serving

L-Arginine

Interacts with
403 drugs
500 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine monograph & interactions

Pomanox

Interacts with
922 drugs
375 mg per serving Form: Pomegranate Whole Fruit Extract

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Pomanox monograph & interactions

Hawthorn Flower, Leaf Extract

Interacts with
191 drugs
50 mg per serving Form: Crataegus monogyna Flower Extract, Crataegus monogyna Leaf Extract

Hawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when...

Hawthorn Flower, Leaf Extract monograph & interactions

Other (inactive) ingredients: Natural flavors, Citric Acid, Red Beet, Powder, Malic Acid, Monk Fruit Extract, Stevia leaf extract, Sea Salt. These complete the product’s ingredient list but are not active constituents.

Interaction report

AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN Drug Interactions

Want to check YOUR meds against AngiNOX Elite Natural Fruit Punch Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,071Drugs
14 Major 560 Moderate 497 Minor

Ingredients driving the most interactions

Pomanox 922
L-Arginine 403
Hawthorn Flower, Leaf Extract 191

Individual Drug Interactions

The ingredients in AngiNOX Elite Natural Fruit Punch Flavor interact with 1,071 drugs. Click any drug to see the details.

3 of the 5 ingredients in AngiNOX Elite Natural Fruit Punch Flavor interact with drugs. Each result below shows which ingredient is responsible. Pomanox L-Arginine Hawthorn Flower, Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in AngiNOX Elite Natural Fruit Punch Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pomanox9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D
Pomanox full monograph & interactions

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

Hawthorn Flower, Leaf Extract6 drug types · 191 drugs

Nitrates

Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.

Likelihood Probable Evidence D
Phosphodiesterase-5 Inhibitors

Theoretically, concomitant use might result in additive vasodilation and hypotension.
Hawthorn might inhibit PDE-5 and cause vasodilation.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that hawthorn can inhibit platelet aggregation. However, its effect in humans is unclear. One observational study shows that patients taking hawthorn shortly before undergoing coronary artery bypass graft (CABG) surgery or valve replacement surgery have a 10% incidence of postoperative bleeding, compared with 1% in those who never consumed hawthorn extract. However, clinical research shows that taking a specific preparation of dried hawthorn leaves and flowers (Crataesor, Soria Natural Lab) 800 mg three times daily for 15 days does not affect platelet aggregation or levels of thromboxane B2, the metabolite of thromboxane A2, in healthy humans.

Likelihood Possible Evidence D
Beta-Blockers

Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
Some evidence shows that hawthorn might lower blood pressure and heart rate.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, hawthorn might potentiate the effects and adverse effects of digoxin.
Hawthorn appears to improve cardiac output; however, hawthorn does not appear to affect digoxin pharmacokinetics. Case reports suggest that at least one species of hawthorn root extract (Crataegus mexicana) may produce adverse effects similar to digoxin and can cross-react with digoxin assays, leading to falsely elevated plasma digoxin levels.

Likelihood Possible Evidence D
Hawthorn Flower, Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for AngiNOX Elite Natural Fruit Punch Flavor, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
xymogen.com
Pharmacist Counseling Corner

AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN: Common Questions

Does AngiNOX Elite Natural Fruit Punch Flavor by XYMOGEN interact with any medications?
Yes. Based on its ingredients, AngiNOX Elite Natural Fruit Punch Flavor has a known interaction with 1,071 medications, including 14 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AngiNOX Elite Natural Fruit Punch Flavor contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood pressure medication?
Not without checking first. Both L-Arginine and pomegranate can lower blood pressure, and hawthorn does too. Combined with your medication, you could drop too low. Talk to your pharmacist with your specific drugs before starting.
Can I take this if I'm on a blood thinner like warfarin?
You need to check. L-Arginine and hawthorn both may increase bleeding risk, and pomegranate can raise warfarin levels. Your pharmacist needs to review your exact medication.
What are the common side effects of L-Arginine in this product?
Orally, the most common are abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing. Most people tolerate it short-term, but it's not meant for self-treatment without medical guidance.
Is pomegranate in this product safe?
Pomegranate fruit and juice are generally safe in normal amounts and may cause mild diarrhea or gas. This product uses pomegranate extract (Pomanox), so use it cautiously and don't exceed recommended doses due to limited safety data on supplements.
Can I take this during pregnancy?
No. Hawthorn is not recommended during pregnancy due to insufficient safety information. There's also no pregnancy safety data on file for the other active ingredients in this product — talk to your doctor before use.
Can I take this while breastfeeding?
Hawthorn should be avoided while breastfeeding. We don't have breastfeeding safety data for the other active ingredients either, so check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AngiNOX Elite Natural Fruit Punch Flavor label
Go deeper

The Full Monographs Behind AngiNOX Elite Natural Fruit Punch Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Pomegranate

Interacts with 922 drugs

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...

Read the full Pomegranate monograph → Herb & supplement monograph

Hawthorn

Interacts with 191 drugs

Hawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when added to standard care. However, the ev...

Read the full Hawthorn monograph →
Sources

Sources & How We Checked

AngiNOX Elite Natural Fruit Punch Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 118 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
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Pomegranate 27 references
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Hawthorn 25 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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