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Dietary supplement

Artichoke Extract Ingredients & Drug Interactions

by Herbadiet

Artichoke Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artichoke Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artichoke Extract is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 363 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke leaf extract powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artichoke Extract by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Artichoke Extract by Herbadiet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artichoke Extract by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: artichoke leaf extract powder. Artichoke has been studied for effects on cholesterol levels, digestive discomfort (indigestion), and fatty liver disease.

There are no inactive ingredients (fillers or binders) listed for this powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Artichoke's overall clinical evidence instead.

Moderate

Some clinical evidence supports Artichoke for:

Why this rating?
  • The label markets general wellness (“digestive support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Dyspepsia — rated "Possibly Effective" (Natural Medicines).
  • On file: Hyperlipidemia — rated "Possibly Effective" (Natural Medicines).

The evidence supports artichoke leaf extract as possibly effective for high cholesterol (hyperlipidemia) and digestive discomfort (dyspepsia), based on clinical trial data. For fatty liver disease (nonalcoholic fatty liver disease, or NAFLD), the evidence isn't established enough to rate — we don't have reliable data to say whether it works.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke extract is generally well tolerated when used as a supplement short-term, though quality and dosing vary between products. The most common side effects are abdominal pain, diarrhea, gas, increased hunger, and nausea.

Some people can have an allergic reaction — especially those sensitive to the daisy family (ragweed, chrysanthemums, marigolds, and related plants). Rarely, severe allergic shock (anaphylaxis) has been reported in people sensitive to inulin, a fiber in artichoke.

Avoid this product during pregnancy — there isn't enough safety information. Also avoid it while breastfeeding, since safety hasn't been established.

If you're allergic to plants in the daisy family or have had reactions to artichoke before, talk with your pharmacist or doctor first.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 363 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this artichoke extract, check with your pharmacist if you take blood pressure medications or diabetes medications — artichoke can lower both blood pressure and blood sugar further. Also flag any medications broken down by your liver (CYP2C19 or CYP2B6 substrates), since artichoke may raise their levels, though this hasn't been confirmed in patients yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Herbadiet Artichoke Extract may help with cholesterol and digestion, but it interacts with blood pressure and diabetes medications. If you take either type, or any drug metabolized by your liver, check your medications with the tool on this page before starting.

Avoid it in pregnancy and while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artichoke Extract, straight from the product label.

Brand Herbadiet
Net contents 0 Not Present
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244414
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artichoke Extract by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
1000 mg
IngredientAmount% DV
Artichoke leaf extract powder500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Digestive support

Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast

V vegan

Ethically sourced Scientifically tested Premium grade ingredients

Formula

Standardized extract powder derived from Cynara scolymus leaves

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take up to 1000 mg daily, or as directed by your physician.

Precautions

Keep out of reach of children.

Pregnant or lactating women should consult your physician before use.

Storage

Store in a dry, cool & dark.

FDA Disclaimer Statement

Warning: This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Batch No. ARK-P64

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artichoke Extract by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artichoke Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artichoke Extract by Herbadiet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Amounts shown are per serving.

Artichoke leaf extract powder

Interacts with
363 drugs
500 mg per serving Form: Cynarin

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke leaf extract powder monograph & interactions
Interaction report

Artichoke Extract by Herbadiet Drug Interactions

Want to check YOUR meds against Artichoke Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
363Drugs
363 Moderate

Ingredients driving the most interactions

Artichoke leaf extract powder 363

Individual Drug Interactions

The ingredients in Artichoke Extract interact with 363 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artichoke Extract interact with drugs. Each result below shows which ingredient is responsible. Artichoke leaf extract powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Artichoke Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke leaf extract powder4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke leaf extract powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artichoke Extract, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
Street Address
11, Sector - 14
City
Rohtak
State
Haryana
ZipCode
124001
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Artichoke Extract by Herbadiet: Common Questions

Does Artichoke Extract by Herbadiet interact with any medications?
Yes. Based on its ingredients, Artichoke Extract has a known interaction with 363 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artichoke Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have allergies to plants?
If you're sensitive to the daisy family — ragweed, chrysanthemums, marigolds, daisies, or similar plants — you're at higher risk for an allergic reaction to artichoke. Some people have also had severe allergic shock (anaphylaxis) from inulin in artichoke. Talk to your pharmacist or doctor before taking it if you have plant allergies or have reacted to artichoke before.
What are the most common side effects?
Most people tolerate artichoke extract well, but the most common side effects are abdominal pain, diarrhea, gas, increased hunger, and nausea. These tend to be mild.
Is this safe during pregnancy or breastfeeding?
Not enough safety information exists, so this product is best avoided during pregnancy. Safety while breastfeeding hasn't been established either. Talk with your doctor or pharmacist for personalized advice.
Does artichoke extract really help with cholesterol?
Yes — studies show artichoke extract is possibly effective for high cholesterol (hyperlipidemia). The evidence is strongest for this use.
How much does artichoke lower blood pressure?
In studies, artichoke reduced systolic (top number) blood pressure by around 3 mmHg and diastolic (bottom number) by around 2 mmHg compared to placebo. These are modest drops, but they matter if you already take blood pressure medication.
Can this help with indigestion?
Research shows artichoke extract is possibly effective for digestive discomfort (dyspepsia), so it may help some people with indigestion.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Artichoke Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artichoke Extract label
Go deeper

The Full Monographs Behind Artichoke Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Artichoke Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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