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Dietary supplement

Artichoke (Globe) Max-V Ingredients & Drug Interactions

by Douglas Laboratories

Artichoke (Globe) Max-V label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artichoke (Globe) Max-V against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artichoke (Globe) Max-V is a dietary supplement by Douglas Laboratories with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 363 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Globe Artichoke Herbal Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artichoke (Globe) Max-V by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Artichoke (Globe) Max-V by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artichoke (Globe) Max-V by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Artichoke (Globe) Max-V contains 2 active ingredients, both artichoke in different forms: Globe Artichoke Herbal Extract and Artichoke. These work the same way in your body.

The product also contains cellulose and vegetable stearate as inactive ingredients—the cellulose is a filler and binder, and the vegetable stearate helps hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and liver health support.
  • We looked for evidence on: Biliary disorders, Dyspepsia, Hyperlipidemia, Nonalcoholic fatty liver disease (NAFLD), cholesterol, indigestion — and 1 related terms.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Dyspepsia (Natural Medicines).
  • Also on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia.
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders, Nonalcoholic fatty liver disease (NAFLD).

The evidence for artichoke is modest but real for a couple of uses. It's rated possibly effective for high cholesterol (hyperlipidemia) and for indigestion and digestive upset (dyspepsia).

For fatty liver disease (nonalcoholic fatty liver disease, or NAFLD), the evidence isn't established yet—we don't have enough reliable data to rate it either way.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke is generally well tolerated as a food and short-term supplement, though quality and dosing vary between products. The most common side effects from taking it by mouth are belly pain, diarrhea, gas, hunger, and nausea.

A small number of people may have an allergic reaction, especially those sensitive to the daisy family of plants (ragweed, chrysanthemums, marigolds, daisies, and similar herbs). Rarely, people sensitive to inulin—a fiber in artichoke—have had severe allergic reactions (anaphylaxis).

There isn't enough safety data to use this product during pregnancy or breastfeeding, so it's best avoided in those situations.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 363 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Artichoke (Globe) Max-V, check with your doctor or pharmacist if you take blood pressure–lowering drugs (antihypertensives) or diabetes medications—artichoke may lower both blood pressure and blood sugar further. Also double-check any medications your liver metabolizes using the CYP2C19 or CYP2B6 enzymes, as artichoke may raise their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Artichoke Max-V may help with high cholesterol or indigestion, but it's not right for everyone. If you take blood pressure medication, diabetes medication, or drugs metabolized by your liver's CYP2C19 or CYP2B6 enzymes, you'll want to check with your doctor or pharmacist before starting it.

If you're allergic to ragweed or other daisy-family plants, mention that to your healthcare provider too. Talk it over with your own doctor or pharmacist before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artichoke (Globe) Max-V, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539001110
Net contents 60 Vegetarian Capsules
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 3397
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artichoke (Globe) Max-V by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
310539001110
IngredientAmount% DV
Globe Artichoke Herbal Extract200 mg--
Artichoke100 mg--

Other ingredients: Cellulose, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Standardized Herbal Extract Supplement

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 capsule daily between meals or as advised by your health care professional. If digestive irritation occurs, take with meals.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Caution: If you are pregnant or nursing, of if you have gallstones, consult your healthcare professional before using.

Do not use if you have known allergies against artichokes or other composites, or if you have obstruction of the bile ducts.

Stop use and consult your health care professional if allergic reactions occur.

Tamper resistant package, do not use if outer seal is missing.

Storage

For optimal storage conditions, store in a cool, dry place. (59(deg)-77(deg)F/15(deg)-25(deg)C) (35-65% relative humidity)

Formula

5% cynarin

Globe Artichoke (Cynara scolymus) contains cynarin (a caffeoylquinic acid derivative), sesquiterpene lactones, and flavonoids (scolymoside, inulin, cynaropictin and taraxasterol). This fresh plant extract is standardized at 5% cynarin.

General

Formula #77303

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artichoke (Globe) Max-V by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artichoke (Globe) Max-V label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artichoke (Globe) Max-V by Douglas Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Globe Artichoke Herbal Extract

Interacts with
363 drugs
200 mg per serving

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Globe Artichoke Herbal Extract monograph & interactions

Artichoke

Interacts with
363 drugs
100 mg per serving

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke monograph & interactions

Other (inactive) ingredients: Cellulose, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Artichoke (Globe) Max-V by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Artichoke (Globe) Max-V?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
363Drugs
363 Moderate

Ingredients driving the most interactions

Globe Artichoke Herbal Extract 363

Individual Drug Interactions

The ingredients in Artichoke (Globe) Max-V interact with 363 drugs. Click any drug to see the details.

1 of the 2 ingredients in Artichoke (Globe) Max-V interact with drugs. Each result below shows which ingredient is responsible. Globe Artichoke Herbal Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Artichoke (Globe) Max-V with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Globe Artichoke Herbal Extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Globe Artichoke Herbal Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artichoke (Globe) Max-V, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Artichoke (Globe) Max-V by Douglas Laboratories: Common Questions

Does Artichoke (Globe) Max-V by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Artichoke (Globe) Max-V has a known interaction with 363 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artichoke (Globe) Max-V contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
You'll need to talk with your doctor or pharmacist first. Artichoke can lower blood pressure on its own, so combining it with a blood pressure drug could push your levels too low. They can help you decide whether it's safe for you or if you need to monitor your blood pressure more closely.
What are the most common side effects?
Most people tolerate artichoke well, but some experience belly pain, diarrhea, gas, hunger, or nausea. If you notice these, they're usually mild, but let your pharmacist know if they bother you or don't go away.
Can I take this if I'm allergic to ragweed?
You should be cautious. Artichoke is related to ragweed and other daisy-family plants, and people allergic to those plants have a higher risk of reacting to artichoke. Talk with your doctor or pharmacist before using it.
Is this safe in pregnancy or while breastfeeding?
There isn't enough safety information to recommend it during pregnancy or breastfeeding, so it's best avoided. If you're pregnant, planning to be, or breastfeeding, check with your doctor or pharmacist before using any supplement.
Does artichoke actually work for cholesterol and digestion?
The evidence suggests it may help modestly with both high cholesterol and indigestion, but it's not a proven cure. Results are usually small, and quality varies between products.
Can I take this if I have diabetes?
Not without checking with your doctor first. Artichoke can lower blood sugar on its own, so adding it to diabetes medication might drop your levels too far. Your doctor or pharmacist can help you figure out whether it's safe for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artichoke (Globe) Max-V label
Go deeper

The Full Monographs Behind Artichoke (Globe) Max-V’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Artichoke (Globe) Max-V's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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