Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Bladder Relief Ingredients & Drug Interactions

by IVL

Bladder Relief label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bladder Relief against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bladder Relief is a dietary supplement by IVL with 3 active ingredients. Its ingredients are commonly taken for fluid retention (mild diuretic), urinary and bladder concerns, hair, skin, and nail support.Based on those ingredients, 188 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horsetail aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bladder Relief by IVL

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HelloPharmacist Scorecard of Bladder Relief by IVL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Urox Proprietary Blend” is a proprietary blend — the label gives one combined amount (840 mg) without saying how much of each component you get.

Bladder Relief contains three active ingredients: Cratevox Three-leaf Caper stem bark extract, a proprietary blend called Urox (which contains Lindera Root Extract), and Horsetail aerial parts extract. The product also includes inactive ingredients — hydroxypropyl methylcellulose, water, rice flour, and silica — which act as fillers and binders in the capsule.

Horsetail is traditionally used for urinary and kidney support. The other two active ingredients are part of the Urox blend, designed to target bladder function, though we don't have detailed breakdown data on their individual roles.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Horsetail's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy bladder function and control urgency.
  • We looked for evidence on: Urinary incontinence, Urinary tract infections (UTIs), overactive bladder, bladder tone, urinary frequency.
  • The closest evidence on file: Horsetail is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Horsetail is rated "Insufficient Reliable Evidence To Rate" for Urinary incontinence.

The evidence for this product's claimed uses isn't established in the data we hold. Horsetail has been studied for urinary incontinence, obesity, tonsillitis, and hair loss (androgenic alopecia), but the research is insufficient to rate whether it actually works for any of these conditions.

If you're considering Bladder Relief for a specific health concern, talk with your doctor about what the current evidence actually supports.

The evidence, ingredient by ingredient Horsetail

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Horsetail is generally well tolerated for short-term use in healthy adults, but long-term use carries real risks that aren't fully understood. The most common side effects from oral horsetail in limited clinical trials are abdominal bloating, increased bowel movements, and nausea.

One concern is thiaminase — a substance in crude horsetail that can cause thiamine (vitamin B1) deficiency with prolonged use; however, Canadian horsetail products must be certified free from thiaminase-like activity. Horsetail should not be used during pregnancy or while breastfeeding — there isn't enough safety data, and the safety notes advise against it.

We hold no pregnancy or breastfeeding data for the Cratevox or Lindera ingredients. If you're pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Horsetail

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horsetail.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 188 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you're on antiretroviral therapy (especially NRTIs or efavirenz), antidiabetes drugs, diuretics, or lithium — all have documented Moderate interactions with horsetail. These are serious enough to warrant a conversation before you combine them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Bladder Relief may be worth considering if you're looking for short-term urinary support, but horsetail isn't proven effective for incontinence in the data we hold. The main caution is interactions with antiviral drugs (including HIV medications), antidiabetes drugs, diuretics, and lithium — all Moderate severity.

If you take any prescription medication, check it with the tool on this page and confirm with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bladder Relief, straight from the product label.

Brand IVL
Barcode (UPC) X002V8RZCV
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 277916
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bladder Relief by IVL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
X002V8RZCV
IngredientAmount% DV
Cratevox Three-leaf Caper (Crateva nurvala) stem bark extract0 NP--
Urox Proprietary Blend840 mg--
Lindera Root Extract0 NP--
Horsetail aerial parts extract0 NP--

Other ingredients: Hydroxypropyl Methylcellulose, Water, Rice, Flour, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

formulated to help you control the urgency!

Bladder Relief is made using Urox, a unique patented Australian formula that has been shown in clinical research to support healthy bladder function and rejuvenate tone. The specialized herbal extracts have a long history of traditional herbal use for healthy bladder function. Results have been seen in 2-4 weeks and improves with extended use.

Vegan

Gluten free

Clinically researched urinary control Promotes bladder tone Supports healthy bladder function Promotes normal frequency

Suggested/Recommended/Usage/Directions

Suggested Use: Take two (2) capsules daily with food. For faster results, two capsules twice daily can be taken for the first month of use.

General Statements

365 day money-back guarantee

To reorder call: 800-218-1379

Seals/Symbols

Sourced from a GMP Certified Facility

Precautions

Please consult your healthcare practitioner before using any nutritional supplement, especially if you are taking medications on a regular basis, anticipate surgery, or are otherwise under medical supervision. Product not intended for use by children under 18 or those who are pregnant or lactating.

Product not intended for use by children under 18 or those who are pregnant or lactating.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright 2021 Youth Extension Solutions

US Patent No. 9,452,191 Urox and Cratevox are trademarks of Seipel Group Pty Ltd.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bladder Relief by IVL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bladder Relief label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bladder Relief by IVL

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Urox Proprietary Blend

840 mg per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Rice, Flour, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bladder Relief by IVL Drug Interactions

Want to check YOUR meds against Bladder Relief?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
188Drugs
188 Moderate

Ingredients driving the most interactions

Horsetail aerial parts extract 188

Individual Drug Interactions

The ingredients in Bladder Relief interact with 188 drugs. Click any drug to see the details.

1 of the 3 ingredients in Bladder Relief interact with drugs. Each result below shows which ingredient is responsible. Horsetail aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bladder Relief with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horsetail aerial parts extract5 drug types · 188 drugs

Antidiabetes Drugs

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.

Likelihood Possible Evidence D
Efavirenz (Sustiva)

Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Nucleoside Reverse Transcriptase Inhibitors (Nrtis)

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Horsetail aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bladder Relief, from the product label.

IVL

See all IVL products
Name
Independent Vital Life LLC
Street Address
PO Box 3520
City
Cottonwood
State
AZ
ZipCode
86326
Phone Number
800-218-1379
Web Address
www.IVL.com
Pharmacist Counseling Corner

Bladder Relief by IVL: Common Questions

Does Bladder Relief by IVL interact with any medications?
Yes. Based on its ingredients, Bladder Relief has a known interaction with 188 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bladder Relief contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is horsetail safe to use long-term?
No. The safety data supports short-term use in healthy adults only. Long-term use carries real risks that aren't fully understood, including the possibility of thiamine deficiency if the horsetail isn't certified free from thiaminase.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data, and the product is advised against during pregnancy and lactation. Talk with your doctor or pharmacist before considering it.
What are the side effects I might experience?
The most common side effects reported in clinical trials are abdominal bloating, increased bowel movements, and nausea. There's also a rare case report of a skin reaction (seborrheic dermatitis) from topical horsetail application.
Does this product actually work for bladder incontinence?
The evidence isn't established in the data we hold — horsetail is rated as having insufficient reliable evidence for urinary incontinence. Talk with your doctor about proven options for your specific situation.
What if I take lithium or a water pill — can I use this?
No — don't without talking to your doctor or pharmacist first. Horsetail may increase lithium levels and may increase potassium loss if you're on a diuretic. Both are Moderate interactions that need professional guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bladder Relief label
Go deeper

The Full Monographs Behind Bladder Relief’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horsetail

Interacts with 188 drugs

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...

Read the full Horsetail monograph →
Sources

Sources & How We Checked

Bladder Relief's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horsetail 14 references
  1. Sudan BJ. Seborrhoeic dermatitis induced by nicotine of horsetails (Equisetum arvense L.). Contact Dermatitis 1985;13:201-2.
  2. Perez Gutierrez RM, Laguna GY, Walkowski A. Diuretic activity of Mexican equisetum. J Ethnopharmacol 1985;14:269-72. PubMed
  3. Lemus I, Garcia R, Erazo S, et al. Diuretic activity of an Equisetum bogotense tea (Platero herb): evaluation in healthy volunteers. J Ethnopharmacol 1996;54:55-8. PubMed
  4. Revilla MC, Andrade-Cetto A, Islas S, Wiedenfeld H. Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients. J Ethnopharmacol 2002;81:117-20. PubMed
  5. Tiktinskii, O. L. and Bablumian, I. A. [Therapeutic action of Java tea and field horsetail in uric acid diathesis]. Urol.Nefrol.(Mosk) 1983;3(1):47-50.
  6. Henderson JA, Evans EV, and McIntosh RA. The antithiamine action of Equisetum. J Amer Vet Med Assoc 1952;120:375-378.
  7. Carneiro DM, Freire RC, Honório TC, Zoghaib I, Cardoso FF, Tresvenzol LM, de Paula JR, Sousa AL, Jardim PC, da Cunha LC. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Voluntee
  8. Klnçalp S, Ekiz F, Basar Ö, Coban S, Yüksel O. Equisetum arvense (Field Horsetail)-induced liver injury. Eur J Gastroenterol Hepatol. 2012 Feb;24(2):213-4. PubMed
  9. Ortega García JA, Angulo MG, Sobrino-Najul EJ, Soldin OP, Mira AP, Martínez-Salcedo E, Claudio L. Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report. J Med Case Rep. 2011 M PubMed
  10. Cordova E, Morganti L, Rodriguez C. Possible Drug-Herb Interaction between Herbal Supplement Containing Horsetail (Equisetum arvense) and Antiretroviral Drugs. J Int Assoc Provid AIDS Care. 2017;16(1):11-13.
  11. García Gavilán MD, Moreno García AM, Rosales Zabal JM, Navarro Jarabo JM, Sánchez Cantos A. Case of drug-induced acute pancreatitis produced by horsetail infusions. Rev Esp Enferm Dig. 2017 Apr;109(4):301-304. PubMed
  12. Vieira GT, de Oliveira TT, Carneiro MAA, et al. Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. J Ethnopharmacol. 2020;260:112898. PubMed
  13. Health Canada. Organism-Equisetum arvense. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredReq.do?id=6117&lang=eng. Accessed 21-July 2021.
  14. Bates D, Duong TB, Kheyson S, Moore K. Hyponatremia Secondary to Decreased Oral Intake and SIADH and Possibly Exacerbated by Horsetail (Equisetum arvense). Can J Hosp Pharm 2021;74(4):386-389. PubMed

See these in context on the Horsetail monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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