Interactions on record — worth a quick check against your medications. Based on 8 of 9 ingredients. Check your meds →
Dietary supplement

ProstaEZ Ingredients & Drug Interactions

by IVL

ProstaEZ label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ProstaEZ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ProstaEZ is a dietary supplement by IVL with 9 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 548 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Selenium, Stinging Nettle Root Extract, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ProstaEZ by IVL

Ask about any prescription or over-the-counter medication and we check it for interactions with ProstaEZ by IVL — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ProstaEZ by IVL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 6 of its 9 active ingredients.
  • “Amino Acid Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

ProstaEZ contains 9 ingredients aimed at prostate and urinary health. The active components include L-glycine, L-glutamic acid, zinc, selenium, L-alanine, stinging nettle root extract, beta-sitosterol, pumpkin powder, and pygeum bark extract.

Inactive ingredients — the capsule material and fillers — include hydroxypropyl methylcellulose, silicon dioxide, and rice flour.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: prostate health as men age.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Urinary symptoms in men, Prostate enlargement.
  • The strongest evidence on file: Pygeum is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Beta-sitosterol is rated "Likely Effective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH).

Evidence for this formula's ingredients varies. Beta-sitosterol and pygeum bark extract are both likely effective for benign prostatic hyperplasia (BPH), the enlargement of the prostate that causes urinary symptoms.

Stinging nettle is possibly effective for diabetes and possibly effective for BPH. Pumpkin powder is possibly effective for BPH.

Glycine has insufficient evidence to support its use for BPH. Zinc, selenium, and L-alanine have no established effectiveness ratings for prostate or urinary conditions in our data.

The evidence, ingredient by ingredient Zinc Selenium Glycine Alpha-alanine Stinging Nettle Beta-sitosterol Pumpkin Pygeum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients here are generally well tolerated at typical doses. Glycine rarely causes mild sedation, irritability, insomnia, fatigue, memory problems, headache, soft stools, nausea, vomiting, or upper stomach discomfort — symptoms resolve quickly if you stop.

Zinc at doses below 40 mg daily is well tolerated but can cause abdominal cramps, diarrhea, metallic taste, nausea, and vomiting (worse at higher doses); high doses long-term may lead to copper deficiency. Selenium at or below 400 mcg daily is generally well tolerated but excessive amounts can cause hair loss, skin problems, fatigue, nail changes, nausea, vomiting, and weight loss; there's also a concern about increased risk of certain skin cancers with long-term supplementation.

Stinging nettle is generally well tolerated but may cause constipation or diarrhea and rarely has caused liver issues in case reports. Beta-sitosterol is generally well tolerated orally but may cause constipation, diarrhea, gas, indigestion, nausea, or loss of appetite; it can also worsen acne.

Pumpkin powder is generally well tolerated but may cause abdominal discomfort, diarrhea, nausea, or vomiting. Pygeum is generally well tolerated short-term, though long-term safety data are limited.

Side effects, ingredient by ingredient Zinc Selenium Glycine Alpha-alanine Stinging Nettle Beta-sitosterol Pumpkin Pygeum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 8 matched ingredients can interact with medications — Stinging Nettle, Pumpkin, Zinc, Selenium, Glycine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 548 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking ProstaEZ, check with your pharmacist if you take clozapine (Clozaril) — glycine may worsen its effects. If you're on any antibiotic (especially quinolones, tetracyclines, or cephalexin), penicillamine, ritonavir, or integrase inhibitors for HIV, space this product at least 2–6 hours away from your dose.

If you take blood thinners or antiplatelet drugs (including warfarin), barbiturates, immunosuppressants, diabetes medications, diuretics, or lithium, discuss this product with your pharmacist before use.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

ProstaEZ contains ingredients with evidence for benign prostatic hyperplasia — chiefly beta-sitosterol and pygeum — but you need to check your medications first, especially if you take clozapine, antibiotics, blood thinners, immunosuppressants, diabetes or diuretic medications, or lithium. Talk to your pharmacist or doctor before starting, particularly if you're on any prescriptions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ProstaEZ, straight from the product label.

Brand IVL
Barcode (UPC) X002S44HIN
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 307018
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Seniors/Mature (>50 Years) - Men ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ProstaEZ by IVL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X002S44HIN
IngredientAmount% DV
L-Glycine0 NP--
L-Glutamic Acid0 NP--
Zinc10 mg91%
Selenium150 mcg273%
Amino Acid Blend500 mg--
L-Alanine0 NP--
Stinging Nettle Root Extract150 mg--
Beta-Sitosterol70 mg--
Pumpkin, Powder500 mg--
Pygeum Bark Extract30 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Silicon Dioxide, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take two (2) capsules in the morning and two (2) before bedtime with food.

Storage

Store in a cool, dry place.

Formulation

As men age, prostate health becomes increasingly important.

Prostate health Supports healthy prostate function Helps promote healthy bladder function Helps maintain healthy hormone levels

Precautions

Please consult your healthcare practitioner before using any nutritional supplement, especially if you are taking medications on a regular basis, anticipate surgery, or are otherwise under medical supervision. Product not intended for use by children under 18 or women who are pregnant or lactating.

Product not intended for use by children under 18 or women who are pregnant or lactating.

Contains: Soy

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright 2021 Independent Vital Life, LLC

IVL Created by Nature Backed by Science

FDA Statement of Identity

Dietary Supplement

General Statements

To reorder call: 800-218-1379

Formula

ProstaEz contains herbs and nutrients which may help promote normal urinary flow and maintain a healthy prostate.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ProstaEZ by IVL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ProstaEZ label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ProstaEZ by IVL

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
10 mg per serving Form: Zinc Citrate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Selenium

Interacts with
321 drugs
150 mcg per serving Form: Selenium Glycinate

Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...

Selenium monograph & interactions

Amino Acid Blend

500 mg per serving

Stinging Nettle Root Extract

Interacts with
164 drugs
150 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Stinging Nettle Root Extract monograph & interactions

Beta-Sitosterol

No known
interactions
70 mg per serving

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Eviden...

Beta-Sitosterol monograph & interactions

Pumpkin, Powder

Interacts with
1 drug
500 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin, Powder monograph & interactions

Pygeum Bark Extract

No known
interactions
30 mg per serving

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...

Pygeum Bark Extract monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Silicon Dioxide, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

ProstaEZ by IVL Drug Interactions

Want to check YOUR meds against ProstaEZ?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
548Drugs
512 Moderate 36 Minor

Ingredients driving the most interactions

Selenium 321
Stinging Nettle Root Extract 164
Zinc 67
L-Glycine 1
Pumpkin, Powder 1

Individual Drug Interactions

The ingredients in ProstaEZ interact with 548 drugs. Click any drug to see the details.

5 of the 9 ingredients in ProstaEZ interact with drugs. Each result below shows which ingredient is responsible. Selenium Stinging Nettle Root Extract Zinc L-Glycine Pumpkin, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in ProstaEZ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Selenium6 drug types · 321 drugs

Anticoagulant/Antiplatelet Drugs

Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.

Likelihood Possible Evidence D
Barbiturates

Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.

Likelihood Possible Evidence D
Contraceptive Drugs

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.

Likelihood Possible Evidence B
Niacin

Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Selenium full monograph & interactions

Stinging Nettle Root Extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Stinging Nettle Root Extract full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

L-Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
L-Glycine full monograph & interactions

Pumpkin, Powder1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ProstaEZ, from the product label.

IVL

See all IVL products
Name
Independent Vital Life, LLC
Street Address
PO Box 3520
City
Cottonwood
State
AZ
ZipCode
86326
Phone Number
800-218-1379
Web Address
www.IVL.com
Pharmacist Counseling Corner

ProstaEZ by IVL: Common Questions

Does ProstaEZ by IVL interact with any medications?
Yes. Based on its ingredients, ProstaEZ has a known interaction with 548 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ProstaEZ contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does ProstaEZ actually help with prostate problems?
Two of its ingredients — beta-sitosterol and pygeum bark — are likely effective for benign prostatic hyperplasia (BPH), the noncancerous enlargement that causes urinary symptoms. Stinging nettle and pumpkin powder are possibly effective for BPH as well. Glycine has not been reliably studied for prostate health.
Can I take this if I'm on blood thinners like warfarin?
Not without checking with your pharmacist first. Selenium in this product may theoretically interfere with warfarin, and stinging nettle contains vitamin K, which can reduce warfarin's blood-thinning effect. Your doctor may need to adjust your warfarin dose or monitor you more closely.
What are the most common side effects?
Most people tolerate the individual ingredients well. The most frequently reported side effects across the formula are digestive — constipation, diarrhea, gas, nausea, indigestion, and abdominal discomfort. Zinc at high doses can cause a metallic taste. Selenium or stinging nettle in excess may cause fatigue or headache. Side effects are usually mild and reversible if you stop.
Is this safe during pregnancy?
Safety data for several ingredients are not well established or are not on file. Stinging nettle and pumpkin powder are best avoided in pregnancy per the available data. Beta-sitosterol and pygeum should also be avoided. Glycine, zinc, and selenium have no clear pregnancy safety rating in our data — talk to your doctor or pharmacist for personalized advice.
Can I take this with diabetes medication?
Stinging nettle may lower blood sugar and could have an additive effect with diabetes drugs, increasing the risk of low blood sugar. Talk to your pharmacist or doctor before starting ProstaEZ if you're on diabetes medication.
What if I'm taking an antibiotic?
Zinc can interfere with absorption of several antibiotics, especially fluoroquinolones, tetracyclines, cephalexin, and penicillamine. If you're on any of these, take your antibiotic at least 2–6 hours before or after this supplement and confirm the timing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ProstaEZ label
Go deeper

The Full Monographs Behind ProstaEZ’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Selenium

Interacts with 321 drugs

Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who eat a varied diet get enough, and supple...

Read the full Selenium monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Alpha-alanine

Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most people do not need a supplement, and strong...

Read the full Alpha-alanine monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Beta-sitosterol

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker...

Read the full Beta-sitosterol monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Pygeum

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...

Read the full Pygeum monograph →
Sources

Sources & How We Checked

ProstaEZ's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 169 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
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See these in context on the Glycine monograph →

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See these in context on the Zinc monograph →

Selenium 36 references
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See these in context on the Selenium monograph →

Alpha-alanine 2 references
  1. Amino acids — MedlinePlus (NIH) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Alpha-alanine monograph →

Stinging Nettle 23 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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