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Dietary supplement

Calm Unflavored Ingredients & Drug Interactions

by Theramu

Calm Unflavored label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calm Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calm Unflavored is a dietary supplement by Theramu with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Aerial Parts Extract Isolate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calm Unflavored by Theramu

Ask about any prescription or over-the-counter medication and we check it for interactions with Calm Unflavored by Theramu — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calm Unflavored by Theramu

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Calm Unflavored contains one active ingredient: hemp aerial parts extract isolate. The product also lists emu oil and cannabidiol isolate, pure as other ingredients.

Hemp aerial parts — the leaves, stems, and flowers — have been studied for their effects on blood pressure, blood clotting, and how your body processes certain medications. The extract is an isolate, meaning it's been concentrated from the plant material.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hemp product and its label doesn't state a use — see Hemp's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for hemp aerial parts extract isolate is incomplete for the conditions we have data on. For constipation, atopic dermatitis (eczema), and familial hypercholesterolemia (a genetic cholesterol disorder), the research we hold rates the evidence as insufficient — meaning we don't have enough reliable human studies to say whether it works or doesn't.

If you're considering this product for one of those uses, talk with your doctor or pharmacist about what the current evidence actually shows for your situation.

The evidence, ingredient by ingredient Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hemp seed foods are generally well tolerated in normal amounts, but concentrated extracts like this one are less studied, so caution is advised. In larger doses or extract form, safety data is limited.

Rare serious side effects have been reported with hemp products, including anaphylaxis, cases of allergic reaction (swelling, rash, breathing trouble), and in one case report, elevated liver enzymes in a young child given very high doses of hemp extract. Allergy to hemp seed is uncommon but can occur.

Food amounts of hemp seed appear safe, but supplements and concentrated extracts warrant extra care because they haven't been as thoroughly studied as whole foods.

Side effects, ingredient by ingredient Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 939 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take estrogen therapy or hormone-based birth control (Moderate interaction). Also flag any blood thinners like warfarin or aspirin, blood pressure medications, ACE inhibitors, or drugs metabolized by your liver (all Minor interactions).

The ingredient we checked can potentially reduce how well some of those medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Calm Unflavored is a single-ingredient hemp extract product. It may interact with estrogen therapy, blood thinners, blood pressure medications, and drugs your liver metabolizes, so check your exact medications before taking it.

Hemp extracts are less studied than hemp seed foods, so talk with your doctor or pharmacist about whether this is right for you, especially if you're on any of those medication types or have a history of hemp or plant allergies.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calm Unflavored, straight from the product label.

Brand Theramu
Barcode (UPC) 856054005917
Net contents 30 Milliliter(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 305674
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calm Unflavored by Theramu, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Drop(s)
Maximum serving Sizes:
3 Drop(s)
Servings per container
250
UPC/BARCODE
856054005917
IngredientAmount% DV
Hemp Aerial Parts Extract Isolate9 mg--

Other ingredients: Emu Oil, Cannabidiol Isolate, Pure

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Serving size: 2 to 3 drops

Scan QR code for independent labs

Storage

Store at room temperature. Use within 180 days of opening.

Formulation

Gluten-free

Formula

Infused sublingual drops 2250 mg CBD 3 mg CBD per drop

Suggested/Recommended/Usage/Directions

Directions Shake well. Hold 2-3 drops under tongue 3 times daily

FDA Disclaimer Statement

Warning These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Seek professional medical advice before use if pregnant or breastfeeding.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calm Unflavored by Theramu label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calm Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calm Unflavored by Theramu

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Drop(s) Dosage formLiquid Servings per container250 Amounts shown are per serving.

Hemp Aerial Parts Extract Isolate

Interacts with
938 drugs
9 mg per serving

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Hemp Aerial Parts Extract Isolate monograph & interactions

Other (inactive) ingredients: Emu Oil, Cannabidiol Isolate, Pure. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calm Unflavored by Theramu Drug Interactions

Want to check YOUR meds against Calm Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
938Drugs
41 Moderate 897 Minor

Ingredients driving the most interactions

Hemp Aerial Parts Extract Isolate 938

Individual Drug Interactions

The ingredients in Calm Unflavored interact with 938 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calm Unflavored interact with drugs. Each result below shows which ingredient is responsible. Hemp Aerial Parts Extract Isolate

Each ingredient & the kinds of drugs it affects

For each ingredient in Calm Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hemp Aerial Parts Extract Isolate6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp Aerial Parts Extract Isolate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calm Unflavored, from the product label.

Theramu

See all Theramu products
Name
Theramu, LLC
Street Address
PO Box 21445
City
Bakersfield
State
CA
ZipCode
93390
Web Address
Theramu.com
Pharmacist Counseling Corner

Calm Unflavored by Theramu: Common Questions

Does Calm Unflavored by Theramu interact with any medications?
Yes. Based on its ingredients, Calm Unflavored has a known interaction with 938 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calm Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm on birth control or hormone replacement therapy?
There's a Moderate interaction concern — hemp may interfere with how your body uses estrogen. Talk with your doctor or pharmacist before adding this product; they can decide whether it's safe for your specific situation and whether you need any monitoring.
Can I take this if I'm on blood thinners?
Hemp has shown blood-thinning effects in animals, though human data is mixed. Because the interaction is documented as a Minor concern, check with your doctor or pharmacist first — they can assess your individual risk and whether this product is okay for you.
What are the side effects?
In food amounts and in larger doses of hemp seed oil, side effects are rare. Serious but uncommon side effects reported include allergic reactions (swelling, rash, breathing trouble) and very rarely anaphylaxis. Liver enzyme elevation was reported in one case of a young child given very high extract doses. If you develop swelling, rash, or breathing trouble, seek medical care right away.
Does this actually work for constipation or eczema?
The evidence we have isn't strong enough to say. For constipation, atopic dermatitis (eczema), and high cholesterol, we rate the research as insufficient — meaning we don't have enough reliable human studies to know if it helps. Talk with your doctor about what treatments have solid evidence for your condition.
Is this product safe in pregnancy or while breastfeeding?
We don't have safety data on file for hemp aerial parts extract during pregnancy or lactation. Because this is a concentrated extract rather than a food amount, talk with your doctor or pharmacist before taking it if you're pregnant or nursing — they can give you personalized advice based on your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calm Unflavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calm Unflavored label
Go deeper

The Full Monographs Behind Calm Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

Calm Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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