Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Downshift CBN + CBD Oil Ingredients & Drug Interactions

by Bluebird Botanicals

Downshift CBN + CBD Oil label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Downshift CBN + CBD Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Downshift CBN + CBD Oil is a dietary supplement by Bluebird Botanicals with 5 active ingredients. Its ingredients are commonly taken for skin and hair care, source of dietary fats (mcts), hydration with coconut water.Based on those ingredients, 1,018 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Full-Spectrum Hemp, Distillate, Coconut Oil, Fractionated. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Downshift CBN + CBD Oil by Bluebird Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Downshift CBN + CBD Oil by Bluebird Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Downshift CBN + CBD Oil by Bluebird Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (470 mg) without saying how much of each component you get.

Downshift CBN + CBD Oil contains 5 active ingredients. The main components are full-spectrum hemp distillate (which includes cannabinoids like CBD and CBN—compounds naturally found in hemp), fractionated coconut oil (a processed form of coconut oil often used as a carrier), and cannabinol distillate on its own.

The product also contains linalool and beta-caryophyllene, two terpenes (aromatic plant compounds) that contribute to hemp's natural profile. There are no inactive fillers or other ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness data in our monographs for cannabinol (CBN) or the specific combination in this product. For the full-spectrum hemp distillate and hemp seed components, evidence for constipation, eczema, and high cholesterol is insufficient to rate—we simply don't have reliable human studies yet.

Fractionated coconut oil similarly lacks sufficient evidence for diabetes, cholesterol, or weight loss. If you're considering this product for a specific health goal, it's worth discussing what the current evidence does and doesn't support with your doctor or pharmacist.

The evidence, ingredient by ingredient Coconut Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fractionated coconut oil is generally well tolerated in food amounts, though concentrated supplement doses are less well studied—your doctor should approve high-dose use. Coconut can cause allergic reactions ranging from hives to anaphylaxis in people with coconut or tree nut sensitivity; about half of reported reactions involve anaphylaxis.

Hemp products are generally well tolerated in food amounts, but concentrated extracts (like the distillate in this product) are less studied, so caution is advised. Rare cases of anaphylaxis, liver enzyme elevation, and other serious effects have been reported with hemp extracts.

Pregnancy and lactation safety data for hemp extract is not on file, so talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Coconut Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Coconut, Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,019 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Downshift CBN + CBD Oil, check with your doctor or pharmacist if you take hormone therapies (estrogens), as hemp may theoretically interfere with them. Also flag blood pressure medications (antihypertensives and ACE inhibitors), blood thinners (anticoagulants and antiplatelet drugs), antidiabetes drugs, and any medications your liver metabolizes heavily—hemp can induce liver enzymes that speed up how your body clears certain drugs, potentially reducing their effectiveness.

Altogether, these interactions span 1,019 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may work well for some people, but we don't yet have reliable evidence for most claimed uses. If you take hormone therapy, blood pressure medications, blood thinners, or drugs your liver metabolizes heavily, check your exact medications with your pharmacist before adding this product—hemp can interfere with several drug classes.

If you have a tree nut or coconut allergy, avoid it. Talk with your doctor or pharmacist about whether it's a good fit for your health goals and current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Downshift CBN + CBD Oil, straight from the product label.

Brand Bluebird Botanicals
Barcode (UPC) 856888009273
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 307847
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Downshift CBN + CBD Oil by Bluebird Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
0.5 mL
Servings per container
60
UPC/BARCODE
856888009273
IngredientAmount% DV
Proprietary Blend470 mg--
Coconut Oil, Fractionated0 NP--
Full-Spectrum Hemp, Distillate0 NP--
Cannabinol, Distillate0 NP--
Linalool0 NP--
Beta-Caryophyllene0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

CBN: 3 mg per serving CBD: 12 mg per serving CBN: 180 mg per bottle CBD: 720 mg per bottle

Non-synthetic cannabinoids derived from USA-grown hemp.

Total THC less than or equal to 43 mg per container Total THC less than or equal to 0.7 mg per serving

FDA Statement of Identity

Hemp Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA has not evaluated or approved this product for safety or efficacy.

Precautions

Do not exceed 1 mL (2 servings) per day.

Warning: Do not use if pregnant, nursing, or under 18 years of age. Consult your healthcare provider if you are using any prescription medications or have a medical condition.

Warning: Do not use if pregnant, nursing, or under 18 years of age.

This product contains hemp with less than or equal to 0.3% Delta-9-THC on a dry-weight basis. May cause drowsiness; do not operate a vehicle or other heavy machinery when using this product. Warning: Consuming this product can expose you to chemicals including Delta-9-THC, which is known to the state of California to cause birth defects or other reproductive harm. See: www.P65Warnings.ca.gov/food.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 serving (15 drops) by mouth, up to 2 times per night, or as directed by a medical professional.

General Statements

Scan for details

Storage

Store in a cool, dark place.

Seals/Symbols

US Hemp Authority Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Downshift CBN + CBD Oil by Bluebird Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Downshift CBN + CBD Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Downshift CBN + CBD Oil by Bluebird Botanicals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

470 mg per serving
Interaction report

Downshift CBN + CBD Oil by Bluebird Botanicals Drug Interactions

Want to check YOUR meds against Downshift CBN + CBD Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,018Drugs
41 Moderate 977 Minor

Ingredients driving the most interactions

Full-Spectrum Hemp, Distillate 938
Coconut Oil, Fractionated 86

Individual Drug Interactions

The ingredients in Downshift CBN + CBD Oil interact with 1,018 drugs. Click any drug to see the details.

2 of the 5 ingredients in Downshift CBN + CBD Oil interact with drugs. Each result below shows which ingredient is responsible. Full-Spectrum Hemp, Distillate Coconut Oil, Fractionated

Each ingredient & the kinds of drugs it affects

For each ingredient in Downshift CBN + CBD Oil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Full-Spectrum Hemp, Distillate6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Full-Spectrum Hemp, Distillate full monograph & interactions

Coconut Oil, Fractionated1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
Coconut Oil, Fractionated full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Downshift CBN + CBD Oil, from the product label.

Bluebird Botanicals

See all Bluebird Botanicals products
Name
Bluebird Botanicals
City
Louisville
State
CO
ZipCode
80027
Phone Number
(720) 726-5132
Web Address
BluebirdBotanicals.com
Pharmacist Counseling Corner

Downshift CBN + CBD Oil by Bluebird Botanicals: Common Questions

Does Downshift CBN + CBD Oil by Bluebird Botanicals interact with any medications?
Yes. Based on its ingredients, Downshift CBN + CBD Oil has a known interaction with 1,018 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Downshift CBN + CBD Oil contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I take blood pressure medication?
Hemp in this product may theoretically have additive effects with blood pressure drugs and increase the risk of low blood pressure. It's important to check your specific medication with your pharmacist or doctor before starting—they can monitor you if they decide it's okay to use together.
Can I take this if I'm on hormone therapy?
Hemp has estrogenic effects that may theoretically interfere with how hormone therapies work in your body. Talk with your doctor or pharmacist before combining them—they'll need to know what type of hormone therapy you're on to advise you properly.
Will this help with eczema or constipation?
We don't have reliable evidence yet that hemp or coconut oil in this product work for eczema or constipation. The research so far is insufficient to say whether it helps for those uses.
What if I have a tree nut allergy?
Coconut is grouped with tree nuts for allergen purposes in the US. If you have a tree nut or coconut allergy, avoid this product—allergic reactions to coconut can be serious, including anaphylaxis.
Is it safe during pregnancy or breastfeeding?
We don't have enough safety data on file for hemp extract during pregnancy or breastfeeding. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing—they can help you weigh the risks and benefits for your situation.
What is linalool, and why is it in this product?
Linalool is a terpene—a natural aromatic compound found in hemp and other plants. It's part of the product's full spectrum of plant compounds, though we don't have specific interaction data on file for it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Downshift CBN + CBD Oil is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Downshift CBN + CBD Oil label
Go deeper

The Full Monographs Behind Downshift CBN + CBD Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph → Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

Downshift CBN + CBD Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
  3. Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
  4. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

See these in context on the Coconut monograph →

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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