Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Signature CBD Soft Gels 15 mg Ingredients & Drug Interactions

by Bluebird Botanicals

Signature CBD Soft Gels 15 mg label
See full label image
Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Signature CBD Soft Gels 15 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Signature CBD Soft Gels 15 mg is a dietary supplement by Bluebird Botanicals with 4 active ingredients. Its ingredients are commonly taken for respiratory support (asthma, allergies, cough), digestive upset, immune support.Based on those ingredients, 1,339 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Frankincense Resin Extract, Full-Spectrum Hemp Aerial Parts Extract, Black Cumin Seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Signature CBD Soft Gels 15 mg by Bluebird Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Signature CBD Soft Gels 15 mg by Bluebird Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Signature CBD Soft Gels 15 mg by Bluebird Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (375 mg) without saying how much of each component you get.

This product contains 4 active ingredients: black cumin seed oil, full-spectrum hemp aerial parts extract, hemp seed oil, and frankincense resin extract. Black cumin seed oil is rich in compounds that have been studied for immune and anti-inflammatory effects.

The hemp ingredients provide phytocannabinoids and other plant compounds from hemp seed and the whole plant. Frankincense resin extract contains boswellic acids, traditionally used to support joint and respiratory comfort.

The softgel capsule itself is made with bovine gelatin, glycerin, and purified water — the inactive ingredients that hold everything together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Osteoarthritis — rated "Possibly Effective" (Boswellia Serrata) (Natural Medicines).
  • On file: Acne — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Asthma — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Chronic obstructive pulmonary disease (COPD) — rated "Possibly Effective" (Black Seed) (Natural Medicines).

The evidence for what this product works for is mixed. Black cumin seed oil shows possibly effective evidence for acne, hay fever, asthma, H. pylori infection, and diabetes.

Frankincense resin extract shows possibly effective evidence for osteoarthritis, but has insufficient evidence for hay fever, Alzheimer's disease, asthma, and cluster headache. For the hemp ingredients — the full-spectrum extract and hemp seed oil — the evidence we hold is insufficient to rate their effectiveness for constipation, eczema, or high cholesterol.

The evidence, ingredient by ingredient Black Seed Hemp Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black cumin seed oil is likely safe in food amounts, but supplement doses like those in this product are less studied long-term. The adverse effects data shows that black seed is generally well tolerated, though some people report constipation, stomach burning or discomfort, nausea, and vomiting.

One clinical trial reported relatively severe menstrual bleeding. In gastrointestinal side effects, about one in five people taking black seed oil orally experienced some GI complaints in one trial, though they were rare in another.

Hemp products are generally well tolerated in food amounts, and hemp seed oil appears well tolerated in larger amounts. Serious side effects (anaphylaxis, long QT syndrome, syncope) have been reported rarely.

A very rare case of hepatitis and elevated liver enzymes occurred in a small child given a much higher phytocannabinoid dose repeatedly. Frankincense resin extract is generally well tolerated short-term; the most common side effects are abdominal pain, diarrhea, headache, heartburn, itching, and nausea.

Large amounts can theoretically cause bezoar formation (a mass in the gut). Black cumin seed oil is likely unsafe in pregnancy in supplement doses; frankincense should be avoided during pregnancy and breastfeeding due to insufficient safety data.

For hemp ingredients, there isn't enough data on file to know either way during pregnancy or breastfeeding — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Black Seed Hemp Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Boswellia Serrata, Black Seed, Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,340 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin) — black cumin seed oil may increase bleeding risk. Also check if you're on central nervous system depressants (sedatives, opioids), antidepressants, blood pressure medications, diabetes drugs, diuretics, immunosuppressants, or hormone therapy, as black cumin interacts with all of these.

Additionally, if you take medications broken down by liver enzymes CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4, frankincense and hemp may affect their levels — this includes many common drugs. Your pharmacist can run a check on your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is geared toward people interested in using CBD and complementary botanical support. If you take any blood thinners, antidepressants, blood pressure medications, diabetes drugs, or immunosuppressants, you should check your specific medications with your pharmacist before starting.

Pregnant or breastfeeding people should discuss this product with their doctor or pharmacist first, given the safety data on black cumin seed oil and frankincense, and the limited data for hemp.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Signature CBD Soft Gels 15 mg, straight from the product label.

Brand Bluebird Botanicals
Barcode (UPC) 856888009235
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 307857
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Signature CBD Soft Gels 15 mg by Bluebird Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
856888009235
IngredientAmount% DV
Proprietary Blend375 mg--
Black Cumin Seed Oil0 NP--
Full-Spectrum Hemp Aerial Parts Extract0 NP--
Hemp Seed Oil, Virgin0 NP--
Frankincense Resin Extract0 NP--

Other ingredients: Bovine Gelatin, Glycerin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Full-spectrum hemp extract, black seed oil & frankincense CBD: 15 mg per serving CBD: 450 mg per bottle

Non-synthetic cannabinoids derived from USA-grown hemp.

Total THC less than or equal to 22.5 mg per container Total THC less than or equal to 0.75 mg per serving

FDA Statement of Identity

Hemp Supplement

FDA Disclaimer Statement

This product has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA has not evaluated or approved this product for safety or efficacy.

Precautions

Do not exceed 4 soft gels (4 servings) per day.

Warning: Do not use if pregnant, nursing, or under 18 years of age. Consult your healthcare provider if you are using any prescription medications or have a medical condition.

Warning: Do not use if pregnant, nursing, or under 18 years of age.

This product contains hemp with <= 0.3% Delta-9-THC on a dry-weight basis. Consumption could result in a failed drug test.

Warning: Consuming this product can expose you to chemicals including Delta-9-THC, which is known to the state of California to cause birth defects or other reproductive harm. See: www.P65Warnings.ca.gov/food.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested use: Take one soft gel by mouth, up to 4 times per day, or as directed by a medical professional.

General Statements

Scan for details

Storage

Store in a cool, dark place.

Seals/Symbols

US Hemp Authority Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Signature CBD Soft Gels 15 mg by Bluebird Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Signature CBD Soft Gels 15 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Signature CBD Soft Gels 15 mg by Bluebird Botanicals

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Bovine Gelatin, Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Signature CBD Soft Gels 15 mg by Bluebird Botanicals Drug Interactions

Want to check YOUR meds against Signature CBD Soft Gels 15 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,339Drugs
1,339 Moderate

Ingredients driving the most interactions

Frankincense Resin Extract 952
Full-Spectrum Hemp Aerial Parts Extract 938
Black Cumin Seed Oil 912

Individual Drug Interactions

The ingredients in Signature CBD Soft Gels 15 mg interact with 1,339 drugs. Click any drug to see the details.

3 of the 4 ingredients in Signature CBD Soft Gels 15 mg interact with drugs. Each result below shows which ingredient is responsible. Frankincense Resin Extract Full-Spectrum Hemp Aerial Parts Extract Black Cumin Seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Signature CBD Soft Gels 15 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Frankincense Resin Extract6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
Frankincense Resin Extract full monograph & interactions

Full-Spectrum Hemp Aerial Parts Extract6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Full-Spectrum Hemp Aerial Parts Extract full monograph & interactions

Black Cumin Seed Oil14 drug types · 912 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Prednisolone

Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.

Likelihood Possible Evidence D
Black Cumin Seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Signature CBD Soft Gels 15 mg, from the product label.

Bluebird Botanicals

See all Bluebird Botanicals products
Name
Bluebird Botanicals
City
Louisville
State
CO
ZipCode
80027
Phone Number
(720) 726-5132
Web Address
BluebirdBotanicals.com
Pharmacist Counseling Corner

Signature CBD Soft Gels 15 mg by Bluebird Botanicals: Common Questions

Does Signature CBD Soft Gels 15 mg by Bluebird Botanicals interact with any medications?
Yes. Based on its ingredients, Signature CBD Soft Gels 15 mg has a known interaction with 1,339 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Signature CBD Soft Gels 15 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Black cumin seed oil is likely unsafe in supplement doses during pregnancy, so you should avoid it if you're pregnant. Frankincense is best avoided during both pregnancy and breastfeeding due to limited safety data. For the hemp ingredients, there isn't enough data to know either way. Talk with your doctor or pharmacist about your specific situation before taking this product.
What does frankincense in this product do?
Frankincense resin extract contains boswellic acids. It shows possibly effective evidence for osteoarthritis, but for other conditions like hay fever, Alzheimer's disease, asthma, and cluster headache, the evidence we hold is insufficient to rate it.
Is hemp seed oil the same as CBD?
No — this product contains both hemp seed oil (which is mostly fat and nutrients) and full-spectrum hemp aerial parts extract (which includes CBD and other phytocannabinoids). They're different parts of the plant with different compositions.
What side effects might I notice?
Black cumin seed oil most commonly causes constipation, stomach burning or discomfort, nausea, and vomiting. Frankincense extract may cause abdominal pain, diarrhea, headache, heartburn, itching, and nausea. Hemp products are generally well tolerated, though rare serious allergic reactions (anaphylaxis) and rare cardiac effects have been reported.
Does this product work for [condition]?
Black cumin seed oil shows possibly effective evidence for acne, hay fever, asthma, H. pylori, and diabetes. Frankincense shows possibly effective evidence for osteoarthritis only. For the hemp ingredients, the evidence we have is insufficient to rate their effectiveness for constipation, eczema, or high cholesterol — there just isn't enough reliable data yet.
Will this interact with my blood pressure medication?
Yes — black cumin seed oil, and to a lesser extent the hemp ingredients, may lower blood pressure further and increase the risk of blood pressure dropping too low. Talk with your pharmacist or doctor about whether this product is right for you if you take blood pressure medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Signature CBD Soft Gels 15 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Signature CBD Soft Gels 15 mg label
Go deeper

The Full Monographs Behind Signature CBD Soft Gels 15 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Seed

Interacts with 912 drugs

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...

Read the full Black Seed monograph → Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

Signature CBD Soft Gels 15 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 88 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Seed 60 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52:23-6.
  3. Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39:59-62.
  4. Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31:283-9. PubMed
  5. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 2008;22:447-52.
  6. Zaoui, A., Cherrah, Y., Lacaille-Dubois, M. A., Settaf, A., Amarouch, H., and Hassar, M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000;55(3):379-382.
  7. Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., and Okuyama, T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol.Pharm.Bull 2001;24(3):307-310. PubMed
  8. Meral, I., Yener, Z., Kahraman, T., and Mert, N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet.Med A Physiol Pathol.Clin Med 2001;48(1
  9. Al Jishi, S. A. and Abuo, Hozaifa B. Effect of Nigella sativa on blood hemostatic function in rats. J Ethnopharmacol. 2003;85(1):7-14. PubMed
  10. Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
  11. Al Naggar, T. B., Gomez-Serranillos, M. P., Carretero, M. E., and Villar, A. M. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88(1):63-68. PubMed
  12. Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother.Res. 2003;17(10):1209-1214.
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  14. Fararh, K. M., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H., and Takewaki, T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet.Sci 2004;77(2):123-129. PubMed
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  52. Ali SM, Chen P, Sheikh S, et al. Thymoquinone with metformin decreases fasting, post prandial glucose, and HbA1c in type 2 diabetic patients. Drug Res (Stuttg) 2021;71(6):302-306. PubMed
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Hemp 12 references
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See these in context on the Hemp monograph →

Boswellia Serrata 16 references
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See these in context on the Boswellia Serrata monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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