Cleanse Now Ingredients & Drug Interactions
by Natrol
What is this page for?
First and foremost: checking Cleanse Now against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cleanse Now is a dietary supplement by Natrol with 3 active ingredients. Its ingredients are commonly taken for antioxidant support, weight loss, energy and vitality.Based on those ingredients, 226 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Senna, Acai extract 4:1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cleanse Now by Natrol
Ask about any prescription or over-the-counter medication and we check it for interactions with Cleanse Now by Natrol — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cleanse Now by Natrol
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Cleanse Now contains three active ingredients. Psyllium is a fiber supplement that supports digestive function.
Acai extract is a concentrated berry preparation that's been traditionally used in wellness products. Senna is a plant-based ingredient known for supporting bowel regularity, and its active compounds are called sennosides.
The capsules also contain several inactive ingredients — cellulose, maltodextrin, gelatin, water, silica, and magnesium stearate — which serve as fillers and binders to hold the product together.
Does it work?
Strong evidence
The evidence we hold doesn't establish that acai is effective for aging skin, athletic performance, erectile dysfunction, or high cholesterol — the data rates all of these as insufficient reliable evidence. The product's other active ingredients, psyllium and sennosides, don't have effectiveness ratings in the data we hold, so we can't speak to their performance here.
How safe is it?
Well-documented data
Acai is generally well tolerated as a food, but concentrated supplements haven't been extensively studied for safety, especially at high doses. For pregnancy and breastfeeding, the data advises caution: acai supplements haven't been studied in pregnancy, and there isn't enough safety information on acai supplements during breastfeeding either.
Talk with your pharmacist or OB about whether this product is right for you if you're pregnant or nursing. We don't hold safety data for psyllium or sennosides.
Meds to double-check
Moderate interaction found
If you take antidiabetes drugs (medications that lower blood sugar), double-check this product with your pharmacist before starting — acai extract can theoretically interfere with your blood sugar control. No other medication interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Cleanse Now is a three-ingredient digestive support product best suited for people looking for fiber and bowel regularity support. If you take any diabetes medications, check with your pharmacist before starting — acai can affect blood sugar control.
Pregnant or breastfeeding? Skip it or talk to your doctor first, since concentrated acai supplements aren't well studied in those situations.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cleanse Now, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cleanse Now by Natrol, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 0.5 g | 1% |
| Psyllium | 50 mg | -- |
| Acai extract 4:1 | 400 mg | -- |
| Senna | 120 mg | -- |
| Sennosides | 12 mg | -- |
Other ingredients: Cellulose, Maltodextrin, Gelatin, Water, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Do not use if you have or develop diarrhea, loose stools, or abdominal pain because senna may worsen these conditions and be harmful to your health.
Read and follow directions carefully.
This product also contains psyllium husk. Taking this product without enough liquid may cause choking. Do not take this product if you have difficulty swallowing.
KEEP OUT OF REACH OF CHILDREN.
Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication or have a medical condition.
NOTICE: Cleanse Now(TM) contains senna.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: On Friday & Saturday (or any 2-day period), take 2 capsules before bedtime with 8 oz of water. Do not take for more than 10 days unless directed by a doctor. Not for children under 12 years of age.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Storage
STORE IN A COOL, DRY PLACE.
General Statements
Açaí capsules may contain an aroma that is characteristic of the high quality Açaí extract in this product.
Cleansing Tips Inside
Easy-to-Use Cleansing Program Helps: ~Detoxify & Promote Waste Elimination ~ Minimize Bloating ~ Promote a Flatter Looking Stomach
NEW
Take this product if you feel that your: ~Jeans are tight around the waist, even if you haven’t gained weight ~Abdomen is bloated & uncomfortable
Brand IP Statement(s)
Contains: (1) Cleanse Now(TM) 10 Capsules (1) Detox Now(TM) 10 Capsules (1) Replenish Now(TM) 10 Capsules
Easy-to-Use This simple program is for busy people who may not find it convenient to follow a complex cleansing program over the duration of several weeks. If you don’t have that kind of time, or need to get results quickly for a special event, consider Natrol(R) AçaíBerry Weekend Cleanse. The 3-day regimen ensures that the cleansing process does not interfere with activities during the week. Start on Friday and be done by Monday morning. Try Natrol(R) AçaíBerry Weekend Cleanse. Smart Cleansing. Serious Results.
Smart Cleansing. Serious Results. AçaíBerry Weekend Cleanse is smart because the three step program supports digestive health quickly and effectively. Step 1. Cleanse Now(TM) Helps minimize occasional constipation and bloating. Step 2. Detox Now(TM) Helps reduce toxins. Provides liver support via antioxidant protection and cell regeneration. Step 3. Replenish Now(TM) Probiotics restore the friendly bacteria that protect and strengthen the GI tract.
Step 1. Cleanse Now(TM)
Formulation
NO Yeast, Wheat, Milk, Egg, Soy, Glutens, Artificial Colors or Flavors, Added Sugar or Preservatives
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cleanse Now by Natrol label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cleanse Now by Natrol
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container5 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Psyllium
Acai extract 4:1
Interacts with86 drugs
Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacki...
Acai extract 4:1 monograph & interactionsSenna
Interacts with140 drugs
Senna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasiona...
Senna monograph & interactionsOther (inactive) ingredients: Cellulose, Maltodextrin, Gelatin, Water, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Cleanse Now by Natrol Drug Interactions
HelloPharmacist Interaction Report
Cleanse Now by Natrol contains ingredients we could check for drug interactions, and we found documented interactions with one medication category.
Acai extract has a Moderate interaction with antidiabetes drugs (medications that lower blood sugar). Preliminary research suggests acai may raise or lower fasting blood glucose levels, which could interfere with how well your diabetes medication works.
Read the full breakdown — every affected drug type, severity by severity
We couldn't fully check psyllium or sennosides — we don't hold interaction data for either of them. Senna's component ingredients are listed separately, but we have no data on file for sennosides.
Altogether, these interactions span 85 individual medications.
Before you start Cleanse Now, run your exact medications through the checker on this page, especially if you take any diabetes drugs. That way we can flag anything specific to your regimen.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cleanse Now?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cleanse Now interact with 226 drugs. Click any drug to see the details.
2 of the 3 ingredients in Cleanse Now interact with drugs. Each result below shows which ingredient is responsible. Senna Acai extract 4:1
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
Acai Extract 4:1Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Extract 4:1 + Acarbose interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
Acai Extract 4:1Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Extract 4:1 + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
Acai Extract 4:1Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Extract 4:1 + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
Acai Extract 4:1Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Extract 4:1 + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
Acai Extract 4:1Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Extract 4:1 + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
Acai Extract 4:1Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Extract 4:1 + Alogliptin, Pioglitazone interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Ammonium Chloride interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
Acai Extract 4:1Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Extract 4:1 + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionArmodafinilNuvigil
How Armodafinil interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesStimulant Laxatives Moderate
Interaction Summary
Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Read the full Sennosides + Armodafinil interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Atenolol, Chlorthalidone interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Azilsartan, Chlorthalidone interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesEstrogens Moderate
Interaction Summary
Theoretically, taking senna may interfere with the absorption of exogenous estrogens.
Read the full Sennosides + Bazedoxifene Acetate, Conjugated Estrogens interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Benzthiazide interactionBisacodylDulcolax, Gentlax
How Bisacodyl interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesStimulant Laxatives Moderate
Interaction Summary
Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Read the full Sennosides + Bisacodyl interactionBisacodyl, DocusateDulcolax Laxative Tabs
How Bisacodyl, Docusate interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesStimulant Laxatives Moderate
Interaction Summary
Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Read the full Sennosides + Bisacodyl, Docusate interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Bisoprolol, Hydrochlorothiazide interactionBumetanideBurinex
How Bumetanide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Bumetanide interactionBumetanide, PotassiumBurinex K
How Bumetanide, Potassium interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Bumetanide, Potassium interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
SennosidesDiuretic Drugs Moderate
Interaction Summary
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Sennosides + Caffeine, Potassium Salicylate, Salicylamide interactionCanagliflozinInvokana
How Canagliflozin interacts with Cleanse Now — through 1 ingredient. Tap an ingredient for the detail:
Acai Extract 4:1Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Extract 4:1 + Canagliflozin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cleanse Now with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Senna
Digoxin (Lanoxin)
Theoretically, senna might increase the risk of adverse effects when taken with digoxin.
Overuse/abuse of senna increases the risk of adverse effects from cardiac glycosides, such as digoxin, due to potassium depletion.
Diuretic Drugs
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of senna might compound diuretic-induced potassium loss and increase the risk for hypokalemia.
Estrogens
Theoretically, taking senna may interfere with the absorption of exogenous estrogens.
Some preliminary clinical evidence suggests that senna reduces the absorption of estradiol and decreases serum concentrations of estrone and estrone sulfate by decreasing intestinal transit time.
Stimulant Laxatives
Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Senna is a stimulant laxative; concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, excessive use of senna might increase the effects of warfarin.
Senna has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. In one case report, excessive use of senna for 3 weeks resulted in diarrhea, bloody stools, and an elevated INR of 11.9.
Acai extract 4:1
Antidiabetes Drugs
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Preliminary clinical research in healthy adults has shown that taking acai may increase or decrease levels of fasting blood glucose.
Brand information
Manufacturer and brand details for Cleanse Now, from the product label.
Natrol
See all Natrol products- Name
- NATROL, Inc.
- City
- Chatsworth
- State
- CA
- ZipCode
- 91311
- Phone Number
- 800.262.8765
- Web Address
- www.natrol.com
Cleanse Now by Natrol: Common Questions
Does Cleanse Now by Natrol interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product actually work for weight loss?
Is acai safe while I'm pregnant?
Is acai safe while breastfeeding?
What does psyllium do in this formula?
Are there any fillers in this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cleanse Now is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cleanse Now’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Acai
Interacts with 86 drugsAcai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacking for the bold health claims often atta...
Read the full Acai monograph → Herb & supplement monographSenna
Interacts with 140 drugsSenna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasionally and for only a few days at a time, s...
Read the full Senna monograph →Sources & How We Checked
Cleanse Now's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 44 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Acai 2 references
- Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011;10:45.
- de Liz S, Cardoso AL, Copetti CLK, et al. Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study. Clin Nutr. 2020;39(12):3629-3636. PubMed
Senna 42 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. PubMed
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Seybold U, Landauer N, Hillebrand S, Goebel FD. Senna-induced hepatitis in a poor metabolizer. Ann Intern Med 2004;141:650-1. PubMed
- Vanderperren B, Rizzo M, Angenot L, et al. Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides. Ann Pharmacother 2005;39:1353-7. PubMed
- Xing JH, Soffer EE. Adverse effects of laxatives. Dis Colon Rectum 2001;44:1201-9. PubMed
- Prior J, White I. Tetany and clubbing in patient who ingested large quantities of senna. Lancet 1978;2:947. PubMed
- Langmead L, Rampton DS. Review article: herbal treatment in gastrointestinal and liver disease--benefits and dangers. Aliment Pharmacol Ther 2001;15:1239-52. PubMed
- Joo JS, Ehrenpreis ED, Gonzalez L, et al. Alterations in colonic anatomy induced by chronic stimulant laxatives: the cathartic colon revisited. J Clin Gastroenterol 1998;26:283-6. PubMed
- Godding EW. Laxatives and the special role of senna. Pharmacology 1988;36:230-6. PubMed
- van Os FH. Anthraquinone derivatives in vegetable laxatives. Pharmacology 1976;14:7-17. PubMed
- Sondheimer JM, Gervaise EP. Lubricant versus laxative in the treatment of chronic functional constipation of children: a comparative study. J Pediatr Gastroenterol Nutr 1982;1:223-6. DOI
- Perkin JM. Constipation in childhood: a controlled comparison between lactulose and standardized senna. Curr Med Res Opin 1977;4:540-3. PubMed
- Shelton MG. Standardized senna in the management of constipation in the puerperium: A clinical trial. S Afr Med J 1980;57:78-80.
- [No authors listed] Senna in the puerperium. Pharmacology 1992;44:23-5. PubMed
- Passmore AP, Davies KW, Flanagan PG, et al. A comparison of Agiolax and lactulose in elderly patients with chronic constipation. Pharmacology 1993;47:249-52. PubMed
- Passmore AP, Wilson-Davies K, Stoker C, Scott ME. Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ 1993;307:769-71. PubMed
- MacLennan WJ, Pooler AFWM. A comparison of sodium picosulphate ("Laxoberal") with standardised senna ("Senokot") in geriatric patients. Curr Med Res Opin. 1974;2:641-7. PubMed
- Kittisupamongkol W, Nilaratanakul V, Kulwichit W. Near-fatal bleeding, senna, and the opposite of lettuce. Lancet 2008;371:784. PubMed
- Prather CM. Pregnancy-related constipation. Curr Gastroenterol Rep 2004;6:402-4. PubMed
- Werthmann WM Jr, Krees SV. Quantitative excretion of Senokot in human breast milk. Med Ann Dist Columbia 1973;42:4-5.
- Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact 1998;14:259-62. PubMed
- Faber P, Strenge-Hesse A. Senna-containing laxatives: excretion in the breast milk? Geburtshilfe Frauenheilkd 1989;49:958-62.
- Faber P, Strenge-Hesse A. Relevance of rhein excretion into breast milk. Pharmacology 1988;36 Suppl 1:212-20. PubMed
- Duncan AS. Standardized senna as a laxative in the puerperium; a clinical assessment. Br Med J 1957;1:439-41. PubMed
- Stickel, F. and Schuppan, D. Herbal medicine in the treatment of liver diseases. Dig.Liver Dis. 2007;39(4):293-304. PubMed
- BALDWIN, W. F. CLINICAL STUDY OF SENNA ADMINISTRATION TO NURSING MOTHERS: ASSESSMENT OF EFFECTS ON INFANT BOWEL HABITS. Can.Med Assoc.J 9-14-1963;89:566-568. DOI
- Sonmez, A., Yilmaz, M. I., Mas, R., Ozcan, A., Celasun, B., Dogru, T., Taslipinar, A., and Kocar, I. H. Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation. Acta Gastroenterol.Belg. 2005;68(3):385-387.
- Beuers, U., Spengler, U., and Pape, G. R. Hepatitis after chronic abuse of senna. Lancet 2-9-1991;337(8737):372-373. PubMed
- Lim, A. K., Hooke, D. H., and Kerr, P. G. Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy. Med J Aust. 1-21-2008;188(2):121-122. PubMed
- McLaughlin, A. F. Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy. Med J Aust. 9-15-2008;189(6):348. PubMed
- Soyuncu, S., Cete, Y., and Nokay, A. E. Portal vein thrombosis related to Cassia angustifolia. Clin.Toxicol.(Phila) 2008;46(8):774-777.
- Levine, D., Goode, A. W., and Wingate, D. L. Purgative abuse associated with reversible cachexia, hypogammaglobulinaemia, and finger clubbing. Lancet 4-25-1981;1(8226):919-920. PubMed
- Malmquist, J., Ericsson, B., Hulten-Nosslin, M. B., Jeppsson, J. O., and Ljungberg, O. Finger clubbing and aspartylglucosamine excretion in a laxative-abusing patient. Postgrad.Med J 1980;56(662):862-864. PubMed
- Lewis, S. J., Heaton, K. W., Oakey, R. E., and McGarrigle, H. H. Lower serum oestrogen concentrations associated with faster intestinal transit. Br.J Cancer 1997;76(3):395-400. PubMed
- Lewis, S. J., Oakey, R. E., and Heaton, K. W. Intestinal absorption of oestrogen: the effect of altering transit-time. Eur.J Gastroenterol.Hepatol. 1998;10(1):33-39. PubMed
- Vilanova-Sanchez A, Gasior AC, Toocheck N, et al. Are Senna based laxatives safe when used as long term treatment for constipation in children? J Pediatr Surg 2018;53(4):722-7. PubMed
- Cogley K, Echevarria A, Correa C, De la Torre-Mondragón L. Contact Burn with Blister Formation in Children Treated with Sennosides. Pediatr Dermatol 2017;34(2):e85-e88. PubMed
- Coskun Y, Yuksel I. Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative prospective randomized study. J Gastroenterol Hepatol 2020;35(11):1923-1929.
- Haoudar A, Chekhlabi N, El Kettani C, Dini N. Acute Hepatitis and Pancytopenia in a Child With Chronic Abuse of Senna. Cureus 2021;13(1):e12436. PubMed
- Irazábal B, Sánchez de Vicente J, Galán C, et al. Anaphylaxis Due to Senna (Cassia angustifolia). J Investig Allergol Clin Immunol 2021;31(1):71-73. PubMed
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