Interactions on record — worth a quick check against your medications. Based on 5 of 12 ingredients. Check your meds →
Dietary supplement

Digestive Enzyme Advantage Ingredients & Drug Interactions

by Williams Nutrition

Digestive Enzyme Advantage label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Enzyme Advantage against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Enzyme Advantage is a dietary supplement by Williams Nutrition with 12 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dandelion extract, Gentian extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestive Enzyme Advantage by Williams Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Enzyme Advantage by Williams Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Digestive Enzyme Advantage by Williams Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 12 active ingredients.
  • “Digestive Enzyme Blend” is a proprietary blend — the label gives one combined amount (210 mg) without saying how much of each component you get.
  • “Soothing Herbal Blend” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.

Digestive Enzyme Advantage contains 12 active ingredients, most of which are digestive enzymes: lactase (breaks down milk sugar), protease (breaks down protein), lipase (breaks down fat), amylase and glucoamylase (break down carbohydrates), alpha-galactosidase (breaks down complex sugars), invertase (breaks down sucrose), acid maltase, peptidase, and ox bile powder (aids fat digestion). The formula also includes dandelion extract and gentian extract as herbal additions in a soothing herbal blend.

Inactive ingredients — microcrystalline cellulose, gelatin, silica, and magnesium stearate — are fillers and binders in the capsule.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive enzyme support with soothing herbs.
  • We looked for evidence on: Dyspepsia, Flatulence, Lactose intolerance, Diarrhea, Constipation, Indigestion — and 3 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Dandelion is rated "Insufficient Reliable Evidence To Rate" for Constipation, Dyspepsia, Flatulence.

The evidence on these ingredients is mixed and limited. Lactase is effective for lactose intolerance, but the evidence for it in prematurity or colic is insufficient.

For dandelion and gentian, there's insufficient reliable evidence to rate them for the conditions they're traditionally used for — things like joint pain, wound healing, or stomach upset. Lipase, protease, and the other digestive enzymes haven't been rated in our data for their effectiveness in this supplement form, so we can't tell you whether the product works for general digestive support.

The evidence, ingredient by ingredient Lactase Proteolytic Enzymes (proteases) Lipase Dandelion Gentian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated when used as directed and is likely safe in pregnancy and lactation. Dandelion and gentian are the concerns here.

Dandelion is generally well tolerated as food but can cause diarrhea, heartburn, or stomach discomfort; rarely, it may trigger allergic reactions including anaphylaxis in sensitive people, especially those allergic to ragweed or related plants. Gentian can upset the stomach and is best avoided in pregnancy; there's not enough safety data for breastfeeding, so avoid it then too.

Protease is generally well tolerated but may rarely cause digestive upset or allergic reactions. Lipase has no reported adverse effects in adults, though it should be used only under medical guidance if you have serious digestive conditions.

We don't have pregnancy or breastfeeding safety data on file for glucoamylase, alpha-galactosidase, amylase, invertase, acid maltase, peptidase, or ox bile powder.

Side effects, ingredient by ingredient Lactase Proteolytic Enzymes (proteases) Lipase Dandelion Gentian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Dandelion, Gentian.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 612 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist if you take any of these: diabetes medications (antidiabetes drugs), blood pressure medications (antihypertensive drugs), blood thinners or antiplatelet drugs, potassium-sparing diuretics (water pills), drugs metabolized by the liver enzyme CYP1A2, fluoroquinolone antibiotics, lithium, or drugs that undergo glucuronidation in the liver. All of these interactions come from dandelion and gentian in the formula.

For the other ingredients we checked — lactase, protease, and lipase — no interactions are documented.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a multi-enzyme digestive support with added herbal extracts. If you take diabetes medications, blood pressure drugs, blood thinners, certain antibiotics, or lithium, talk to your pharmacist before starting — dandelion and gentian may interfere.

If you're pregnant or breastfeeding, check with your doctor first, especially because gentian is best avoided in these periods and safety data on most ingredients is limited. It's generally well tolerated, but people with sensitive stomachs or allergies to ragweed-family plants should be cautious.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzyme Advantage, straight from the product label.

Brand Williams Nutrition
Barcode (UPC) 678829241401
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 315349
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzyme Advantage by Williams Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
678829241401
IngredientAmount% DV
Glucoamylase0 NP--
Digestive Enzyme Blend210 mg--
Alpha-Galactosidase0 NP--
Lactase0 NP--
Soothing Herbal Blend200 mg--
Dandelion extract0 NP--
Amylase0 NP--
Gentian extract0 NP--
Invertase0 NP--
Protease0 NP--
Acid Maltase0 NP--
Peptidase0 NP--
Ox Bile powder100 mg--
Lipase0 NP--

Other ingredients: Microcrystalline Cellulose, Gelatin, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Almost out? Call 1-800-888-1415 or visit healthydirections.com Choose refill & save and Never Run Out!

Suggested/Recommended/Usage/Directions

Digestive Enzyme Advantage is formulated to be taken in conjunction with a high-quality probiotic supplement such as Probiotic Advantage.

Doctor’s Suggested Use: Take 1 capsule as needed before a meal.

Formulation

Unconditionally guaranteed for purity and labeled potency.

Digestive health Digestive comfort Broad spectrum Food breakdown

GF Gluten free

Storage

To preserve quality and freshness, store bottle with cap tightly closed in a cool, dry place.

Precautions

Precautions: Consult a health care practitioner before use if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Digestive enzymes + soothing herbs

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Enzyme Advantage by Williams Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Enzyme Advantage label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Enzyme Advantage by Williams Nutrition

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Digestive Enzyme Blend

210 mg per serving
  • › Glucoamylase
  • › Alpha-Galactosidase
  • › Lactase
  • › Amylase
  • › Invertase
  • › Protease
  • › Acid Maltase
  • › Peptidase
  • › Lipase

Soothing Herbal Blend

200 mg per serving

Ox Bile powder

100 mg per serving Form: Bovine

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzyme Advantage by Williams Nutrition Drug Interactions

Want to check YOUR meds against Digestive Enzyme Advantage?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
612Drugs
612 Moderate

Ingredients driving the most interactions

Dandelion extract 457
Gentian extract 172

Individual Drug Interactions

The ingredients in Digestive Enzyme Advantage interact with 612 drugs. Click any drug to see the details.

2 of the 12 ingredients in Digestive Enzyme Advantage interact with drugs. Each result below shows which ingredient is responsible. Dandelion extract Gentian extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Enzyme Advantage with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dandelion extract7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion extract full monograph & interactions

Gentian extract1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Enzyme Advantage, from the product label.

Williams Nutrition

See all Williams Nutrition products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Phone Number
1-800-888-1415
Web Address
healthydirections.com
Pharmacist Counseling Corner

Digestive Enzyme Advantage by Williams Nutrition: Common Questions

Does Digestive Enzyme Advantage by Williams Nutrition interact with any medications?
Yes. Based on its ingredients, Digestive Enzyme Advantage has a known interaction with 612 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Enzyme Advantage contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product work for gas and bloating?
The product contains enzymes that break down different foods and bile powder to aid digestion, but we don't have effectiveness ratings in our data for general digestive support or bloating. If you have specific digestion issues, talk to your pharmacist about whether the enzyme mix might help you.
Is it safe if I'm lactose intolerant?
Yes — the product contains lactase, which is effective for lactose intolerance and helps you digest milk sugar. That's one of the few ingredients rated as effective in our data.
Can I take this while pregnant?
Gentian extract in this product is best avoided during pregnancy. Lactase is likely safe. For the other ingredients, we don't have enough safety data to say either way. Talk with your doctor or pharmacist before starting, especially if you're already taking medications.
What's dandelion extract in here for?
Dandelion is included as part of the soothing herbal blend, traditionally used to support digestion. However, it does interact with several medication types, so it's important to check with your pharmacist if you take any prescriptions.
Could this cause an allergic reaction?
Rare allergic reactions, including anaphylaxis, have been reported with dandelion — especially in people allergic to ragweed or related plants. Protease and lactase can rarely trigger allergic reactions too. If you have a known plant allergy, mention it to your pharmacist before trying this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzyme Advantage is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzyme Advantage label
Go deeper

The Full Monographs Behind Digestive Enzyme Advantage’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph →
Sources

Sources & How We Checked

Digestive Enzyme Advantage's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Dandelion 27 references
  1. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  2. Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7. PubMed
  3. Hussain Z, Waheed A, Qureshi RA, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res 2004;18:73-7. PubMed
  4. Racz-Kotilla E, Racz G, Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med 1974;26:212-7. PubMed
  5. Zhu M, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci 1999;88:632-4. PubMed
  6. Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
  7. Chivato T, Juan F, Montoro A, Laguna R. Anaphylaxis induced by ingestion of a pollen compound. J Investig Allergol Clin Immunol 1996;6:208-9.
  8. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
  9. Lovell CR, Rowan M. Dandelion dermatitis. Contact Dermatitis 1991;25:185-8. PubMed
  10. Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
  11. Martín-Muñoz MF, Bartolome B, Caminoa M, et al. Bee pollen: a dangerous food for allergic children. Identification of responsible allergens. Allergol Immunopathol (Madr) 2010;38:263-5. PubMed
  12. Neef H, Cilli F, Declerck PJ, et al. Platelet anti-aggregating activity of Taraxacum officinale Weber. Phytotherapy Research 1996;10:s138-s140.
  13. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  14. Posadzki, P., Watson, L. K., and Ernst, E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med 2013;13(1):7-12. PubMed
  15. Wakelin, S. H., Marren, P., Young, E., and Shaw, S. Compositae sensitivity and chronic hand dermatitis in a seven-year-old boy. Br J Dermatol 1997;137(2):289-291. PubMed
  16. Ingber, A. Seasonal allergic contact dermatitis from Taraxacum officinale (dandelion) in an Israeli florist. Contact Dermatitis 2000;43(1):49.
  17. Rodriguez, B., Rodriguez, A., de Barrio, M., Tornero, P., and Baeza, M. L. Asthma induced by canary food mix. Allergy Asthma Proc. 2003;24(4):265-268.
  18. Syhaieva, I. A. [Efficiency of specific immunotherapy in treatment of patients with seasonal allergic rhinitis]. Lik.Sprava. 2006;(1-2):51-53.
  19. Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. PubMed
  20. Goksu, E., Eken, C., Karadeniz, O., and Kucukyilmaz, O. First report of hypoglycemia secondary to dandelion (Taraxacum officinale) ingestion. Am J Emerg.Med 2010;28(1):111-112. PubMed
  21. Fernandez-Gonzalez, D., Gonzalez-Parrado, Z., Vega-Maray, A. M., Valencia-Barrera, R. M., Camazon-Izquierdo, B., De, Nuntiis P., and Mandrioli, P. Platanus pollen allergen, Pla a 1: quantification in the atmosphere and influence on a sensitizing populati
  22. Liang, K. L., Su, M. C., Shiao, J. Y., Wu, S. H., Li, Y. H., and Jiang, R. S. Role of pollen allergy in Taiwanese patients with allergic rhinitis. J Formos.Med Assoc. 2010;109(12):879-885. PubMed
  23. Yang, Y., Zhao, Y., Wang, C. S., Wang, X. D., and Zhang, L. [Prevalence of sensitization to aeroallergens in 10 030 patients with allergic rhinitis]. Zhonghua Er.Bi Yan.Hou Tou.Jing.Wai Ke Za Zhi 2011;46(11):914-920.
  24. Davies, M. G. and Kersey, P. J. Contact allergy to yarrow and dandelion. Contact Dermatitis 1986;14(4):256-257. PubMed
  25. Collins JM and Miller DR. Dandelion green bezoar following antrectomy and vagotomy - case report. J Kansas Med Soc 1966;67(6):303-304.
  26. Moriarty B, Pinney JH, Owen-Casey MP, Rustin MH, Deroide F, Laing C, Davenport A. Digital necrosis from dandelion tea. Br J Dermatol. 2013 Jul;169(1):227-30. PubMed
  27. Onal S, Timur S, Okutucu B, Zihnioglu F. Inhibition of alphaglucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep Biochem Biotechnol 2005;35:29-36.

See these in context on the Dandelion monograph →

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team